<?xml version="1.0"?>
<doi_batch xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://www.crossref.org/schema/4.4.0" xmlns:fr="http://www.crossref.org/fundref.xsd" xmlns:ct="http://www.crossref.org/clinicaltrials.xsd" xmlns:ai="http://www.crossref.org/AccessIndicators.xsd" xmlns:rel="http://www.crossref.org/relations.xsd" xmlns:jats="http://www.ncbi.nlm.nih.gov/JATS1" version="4.4.0" xsi:schemaLocation="http://www.crossref.org/schema/4.4.0 crossref4.4.0.xsd">
  <head>
    <doi_batch_id>TODENTJ-25-03-2019_TODENTJ-9-182</doi_batch_id>
    <timestamp>1553505678</timestamp>
    <depositor>
      <depositor_name>Bentham Open</depositor_name>
      <email_address>doi@benthamopen.net</email_address>
    </depositor>
    <registrant>Bentham Open</registrant>
  </head>
  <body>
    <journal>
      <journal_metadata language="en">
        <full_title>The Open Dentistry Journal</full_title>
        <abbrev_title>TODENTJ</abbrev_title>
        <issn media_type="print">1874-2106</issn>
      </journal_metadata>
      <journal_issue>
        <publication_date media_type="print">
          <month>6</month>
          <day>26</day>
          <year>2015</year>
        </publication_date>
        <journal_volume>
          <volume>9</volume>
        </journal_volume>
        <issue>1</issue>
      </journal_issue>
      <journal_article publication_type="full_text">
        <titles>
          <title> Iatrogenic Damage to the Periodontium Caused by Radiation and Radiotherapy</title>
        </titles>
        <contributors>
          <person_name contributor_role="author" sequence="first">
            <given_name>Najeeb </given_name>
            <surname>Kassim </surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Syed </given_name>
            <surname>Sirajuddin </surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Shriparna </given_name>
            <surname>Biswas </surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Syed </given_name>
            <surname>Rafiuddin </surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Ashwini </given_name>
            <surname>Apine </surname>
          </person_name>
        </contributors>
        <jats:abstract>
                <jats:p>The radio-sensitivity of a tissue or organ is measured by its response to irradiation. Loss of moderate numbers of cells does not affect the function of most organs. However, with loss of large numbers of cells, all affected organisms display a clinical result. The severity of this change depends on the dosage and thus the extent of cell loss. Moderate doses to a localized area may lead to repairable damage. Comparable doses to a whole organism may result in death from damage to the most sensitive systems in the body. </jats:p>
            </jats:abstract>
        <publication_date>
          <month>6</month>
          <day>26</day>
          <year>2015</year>
        </publication_date>
        <pages>
          <first_page>182</first_page>
          <last_page>186</last_page>
        </pages>
        <publisher_item>
          <identifier id_type="sici">TODENTJ-9-182</identifier>
        </publisher_item>
        <crossmark>
          <crossmark_version>1</crossmark_version>
          <crossmark_policy>10.2174/crossmark_policy</crossmark_policy>
          <crossmark_domains>
            <crossmark_domain>
              <domain>opendentistryjournal.com</domain>
            </crossmark_domain>
            <crossmark_domain>
              <domain>benthamopen.com</domain>
            </crossmark_domain>
          </crossmark_domains>
          <crossmark_domain_exclusive>true</crossmark_domain_exclusive>
          <custom_metadata>
            <assertion name="review_status" label="Review Status" group_name="peer_review_details" group_label="Peer Review Details" order="0">Peer Reviewed</assertion>
            <assertion name="review_process" label="Review Process" group_name="peer_review_details" group_label="Peer Review Details" order="1">Single blind</assertion>
            <assertion name="screening_status" label="Screening Status" group_name="plagiarism_screening" group_label="Plagiarism Screening" order="0">Checked with iThenticate</assertion>
            <assertion name="received" label="Received" group_name="publication_history" group_label="Publication History" order="0">2014-12-22</assertion>
            <assertion name="revised" label="Revised" group_name="publication_history" group_label="Publication History" order="1">2015-3-4</assertion>
            <assertion name="accepted" label="Accepted" group_name="publication_history" group_label="Publication History" order="2">2015-3-10</assertion>
            <assertion name="published" label="Published" group_name="publication_history" group_label="Publication History" order="3">2015-6-26</assertion>
            <ai:program name="AccessIndicators">
              <ai:license_ref>http://creativecommons.org/licenses/by-nc/3.0/</ai:license_ref>
            </ai:program>
          </custom_metadata>
        </crossmark>
        <doi_data>
          <doi>10.2174/1874210601509010182</doi>
          <timestamp>1553505678</timestamp>
          <resource>https://opendentistryjournal.com/VOLUME/9/PAGE/182/</resource>
          <collection property="crawler-based">
            <item crawler="google">
              <resource>https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-182/TODENTJ-9-182.pdf</resource>
            </item>
            <item crawler="msn">
              <resource>https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-182/TODENTJ-9-182.pdf</resource>
            </item>
            <item crawler="altavista">
              <resource>https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-182/TODENTJ-9-182.pdf</resource>
            </item>
            <item crawler="yahoo">
              <resource>https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-182/TODENTJ-9-182.pdf</resource>
            </item>
            <item crawler="scirus">
              <resource>https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-182/TODENTJ-9-182.pdf</resource>
            </item>
            <item crawler="iParadigms">
              <resource>https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-182/TODENTJ-9-182.pdf</resource>
            </item>
          </collection>
          <collection property="text-mining">
            <item>
              <resource mime_type="application/pdf">https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-182/TODENTJ-9-182.pdf</resource>
            </item>
            <item>
              <resource mime_type="application/xml">https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-182/TODENTJ-9-182.xml</resource>
            </item>
          </collection>
        </doi_data>
        <citation_list>
          <citation key="refR1">
            <journal_title>Oral Oncol</journal_title>
            <author>Petersen P.E.</author>
            <volume>45</volume>
            <first_page>454</first_page>
            <cYear>2009</cYear>
            <doi>10.1016/j.oraloncology.2008.05.023</doi>
            <unstructured_citation>
                Petersen PE. 
                Oral cancer prevention and control--the approach of the World Health Organization 
                Oral Oncol  
                2009; 
                45
                (4-5)
                : 454-60.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR2">
            <journal_title>Indian J. Cancer</journal_title>
            <author>Mehrotra R.</author>
            <volume>42</volume>
            <first_page>89</first_page>
            <cYear>2005</cYear>
            <doi>10.4103/0019-509X.16698</doi>
            <unstructured_citation>
                Mehrotra R, Singh M, Gupta RK, Singh M, Kapoor AK. 
                Trends of prevalence and pathological spectrum of head and neck cancers in North India 
                Indian J Cancer  
                2005; 
                42
                (2)
                : 89-93.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR3">
            <journal_title>J. Can. Dent. Assoc</journal_title>
            <author>Hancock P.J.</author>
            <volume>69</volume>
            <first_page>585</first_page>
            <cYear>2003</cYear>
            <unstructured_citation>
                Hancock PJ, Epstein JB, Sadler GR. 
                Oral and dental management related to radiation therapy for head and neck cancer 
                J Can Dent Assoc  
                2003; 
                69
                (9)
                : 585-90.
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR4">
            <journal_title>Postgrad. Med</journal_title>
            <author>Dreizen S.</author>
            <volume>61</volume>
            <first_page>85</first_page>
            <cYear>1977</cYear>
            <unstructured_citation>
                Dreizen S, Daly TE, Drane JB, Brown LR. 
                Oral complications of cancer radiotherapy 
                Postgrad Med  
                1977; 
                61
                (2)
                : 85-92.
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR5">
            <journal_title>J. Oral Maxillofac. Surg</journal_title>
            <author>Marx R.E.</author>
            <volume>41</volume>
            <first_page>283</first_page>
            <cYear>1983</cYear>
            <doi>10.1016/0278-2391(83)90294-X</doi>
            <unstructured_citation>
                Marx RE. 
                Osteoradionecrosis: a new concept of its pathophysiology 
                J Oral Maxillofac Surg  
                1983; 
                41
                (5)
                : 283-8.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR6">
            <journal_title>J. Periodontol</journal_title>
            <author>Silverman S.</author>
            <volume>36</volume>
            <first_page>478</first_page>
            <cYear>1965</cYear>
            <doi>10.1902/jop.1965.36.6.478</doi>
            <unstructured_citation>
                Silverman S Jr, Chierici G. 
                Radiation therapy of oral carcinoma. I. Effects on oral tissues and management of the periodontium 
                J Periodontol  
                1965; 
                36
                (6)
                : 478-84.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR7">
            <journal_title>J. Periodontol</journal_title>
            <author>Yusof Z.W.</author>
            <volume>64</volume>
            <first_page>1253</first_page>
            <cYear>1993</cYear>
            <doi>10.1902/jop.1993.64.12.1253</doi>
            <unstructured_citation>
                Yusof ZW, Bakri MM. 
                Severe progressive periodontal destruction due to radiation tissue injury 
                J Periodontol  
                1993; 
                64
                (12)
                : 1253-8.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR8">
            <journal_title>Oral Surg. Oral Med. Oral Pathol</journal_title>
            <author>Marx R.E.</author>
            <volume>64</volume>
            <first_page>379</first_page>
            <cYear>1987</cYear>
            <doi>10.1016/0030-4220(87)90136-8</doi>
            <unstructured_citation>
                Marx RE, Johnson RP. 
                Studies in the radiobiology of osteoradionecrosis and their clinical significance 
                Oral Surg Oral Med Oral Pathol  
                1987; 
                64
                (4)
                : 379-90.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR9">
            <journal_title>Spec. Care Dentist</journal_title>
            <author>Epstein J.B.</author>
            <volume>14</volume>
            <first_page>182</first_page>
            <cYear>1994</cYear>
            <doi>10.1111/j.1754-4505.1994.tb01129.x</doi>
            <unstructured_citation>
                Epstein JB, Corbett T, Galler C, Stevenson-Moore P. 
                Surgical periodontal treatment in the radiotherapy-treated head and neck cancer patient 
                Spec Care Dentist  
                1994; 
                14
                (5)
                : 182-7.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR10">
            <journal_title>Caries Res</journal_title>
            <author>Llory H.</author>
            <volume>6</volume>
            <first_page>298</first_page>
            <cYear>1972</cYear>
            <doi>10.1159/000259809</doi>
            <unstructured_citation>
                Llory H, Dammron A, Gioanni M, Frank RM. 
                Some population changes in oral anaerobic microorganisms, Streptococcus mutans and yeasts following irradiation of the salivry glands 
                Caries Res  
                1972; 
                6
                (4)
                : 298-311.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR11">
            <journal_title>J. Am. Dent. Assoc</journal_title>
            <author>Marciani R.D.</author>
            <volume>123</volume>
            <first_page>108</first_page>
            <cYear>1992</cYear>
            <doi>10.14219/jada.archive.1992.0052</doi>
            <unstructured_citation>
                Marciani RD, Ownby HE. 
                Treating patients before and after irradiation 
                J Am Dent Assoc  
                1992; 
                123
                (2)
                : 108-12.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR12">
            <journal_title>Oral Microbiol. Immunol</journal_title>
            <author>Leung W.K.</author>
            <volume>13</volume>
            <first_page>1</first_page>
            <cYear>1998</cYear>
            <doi>10.1111/j.1399-302X.1998.tb00743.x</doi>
            <unstructured_citation>
                Leung WK, Jin LJ, Samaranayake LP, Chiu GK. 
                Subgingival microbiota of shallow periodontal pockets in individuals after head and neck irradiation 
                Oral Microbiol Immunol  
                1998; 
                13
                (1)
                : 1-10.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR13">
            <journal_title>J. Dent</journal_title>
            <author>Schwarz E.</author>
            <volume>27</volume>
            <first_page>21</first_page>
            <cYear>1999</cYear>
            <doi>10.1016/S0300-5712(98)00024-4</doi>
            <unstructured_citation>
                Schwarz E, Chiu GK, Leung WK. 
                Oral health status of southern Chinese following head and neck irradiation therapy for nasopharyngeal carcinoma 
                J Dent  
                1999; 
                27
                (1)
                : 21-8.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR14">
            <journal_title>Oral Oncol</journal_title>
            <author>Epstein J.B.</author>
            <volume>37</volume>
            <first_page>613</first_page>
            <cYear>2001</cYear>
            <doi>10.1016/S1368-8375(01)00025-2</doi>
            <unstructured_citation>
                Epstein JB, Stevenson-Moore P. 
                Periodontal disease and periodontal management in patients with cancer 
                Oral Oncol  
                2001; 
                37
                (8)
                : 613-9.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR15">
            <journal_title>J. Periodontol</journal_title>
            <author>Yusof Z.W.</author>
            <volume>64</volume>
            <first_page>1253</first_page>
            <cYear>1993</cYear>
            <doi>10.1902/jop.1993.64.12.1253</doi>
            <unstructured_citation>
                Yusof ZW, Bakri MM. 
                Severe progressive periodontal destruction due to radiation tissue injury 
                J Periodontol  
                1993; 
                64
                (12)
                : 1253-8.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR16">
            <journal_title>Oral Surg. Oral Med. Oral Pathol</journal_title>
            <author>Marx R.E.</author>
            <volume>64</volume>
            <first_page>379</first_page>
            <cYear>1987</cYear>
            <doi>10.1016/0030-4220(87)90136-8</doi>
            <unstructured_citation>
                Marx RE, Johnson RP. 
                Studies in the radiobiology of osteoradionecrosis and their clinical significance 
                Oral Surg Oral Med Oral Pathol  
                1987; 
                64
                (4)
                : 379-90.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR17">
            <journal_title>J. Am. Dent. Assoc</journal_title>
            <volume>123</volume>
            <first_page>108</first_page>
            <cYear>1992</cYear>
            <doi>10.14219/jada.archive.1992.0052</doi>
            <unstructured_citation>
                nMarciani RD, Ownby HE. Treating patients before and after irradiation 
                J Am Dent Assoc  
                1992; 
                123
                : 108-12.
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR18">
            <journal_title>J. Periodontol</journal_title>
            <author>Marques M.A.</author>
            <volume>75</volume>
            <first_page>1178</first_page>
            <cYear>2004</cYear>
            <doi>10.1902/jop.2004.75.9.1178</doi>
            <unstructured_citation>
                Marques MA, Dib LL. 
                Periodontal changes in patients undergoing radiotherapy 
                J Periodontol  
                2004; 
                75
                (9)
                : 1178-87.
                
                
                
            </unstructured_citation>
          </citation>
          <citation key="refR19">
            <journal_title>Eur. J. Cancer B Oral Oncol</journal_title>
            <author>Scully C.</author>
            <volume>32B</volume>
            <first_page>281</first_page>
            <cYear>1996</cYear>
            <doi>10.1016/0964-1955(96)00037-1</doi>
            <unstructured_citation>
                Scully C, Epstein JB. 
                Oral health care for the cancer patient 
                Eur J Cancer B Oral Oncol  
                1996; 
                32B
                (5)
                : 281-92.
                
                
                
            </unstructured_citation>
          </citation>
        </citation_list>
      </journal_article>
    </journal>
  </body>
</doi_batch>
