TODENTJ-25-03-2019_TODENTJ-9-168 1553505668 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 5 15 2015 9 1 Gilvanely Cardoso Alves Ana Paula Veras Sobral The aim of this study was to evaluate biocompatibility of an etch-and-rinse adhesive system based in tertiary butanol applied in deep cavity human teeth with approximately 1 mm of remaining dentin by observing histological changes of the pulp tissue of humans at intervals of 01, 07, 14 and 21 days. Twenty third molars with indication for xtraction from patients of both sexes, presenting no systemic alterations were used. Class I cavity was made deeper and then, XP BOND adhesive system and resin Filtek Z250 were applied. The sample was divided into four groups according to the time intervals between the application of adhesive system and extraction. Morphologic criteria analysed considered the presence of hyperemia, type of inflammatory cell response, organization of odontoblast cells layer, organization of pulp tissue and the presence or absence of bacteria. Data were submitted to Fisher Exact Test p> 0.05. We observed mild inflammatory infiltrate, preserved pulp tissue morphology, disorganization of the odontoblast layer in most specimens, as well as absence of bacteria at the intervals of 01, 07, 14 and 21 days. In some cases there was pulp hyperemia. The etchand- rinse adhesive system based in tertiary butanol showed satisfactory behavior in the conditions studied. 5 15 2015 168 173 TODENTJ-9-168 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2014-12-31 2015-3-10 2015-3-24 2015-5-15 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601509010168 1553505668 https://opendentistryjournal.com/VOLUME/9/PAGE/168/ https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-168/TODENTJ-9-168.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-168/TODENTJ-9-168.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-168/TODENTJ-9-168.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-168/TODENTJ-9-168.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-168/TODENTJ-9-168.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-168/TODENTJ-9-168.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-168/TODENTJ-9-168.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-168/TODENTJ-9-168.xml Biomaterials Nie J 23 1221 2002 Nie J, Bowman CN. 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