TODENTJ-25-03-2019_TODENTJ-9-120
1553505648
Bentham Open
doi@benthamopen.net
Bentham Open
The Open Dentistry Journal
TODENTJ
1874-2106
3
31
2015
9
1
Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients
Kosuke
Naganawa
Eiji
Takayama
Makoto
Adachi
Kenji
Mitsudo
Masaki
Iida
Masako
Kamiya-Mizuno
Harumi
Kawaki
Masao
Ichinose
Masayuki
Motohashi
Yasunori
Muramatsu
Iwai
Tohnai
Shin-Ichiro
Sumitomo
Michio
Shikimori
Nobuo
Kondoh
In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.
3
31
2015
120
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TODENTJ-9-120
1
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2015-1-12
2015-2-26
2015-3-3
2015-3-31
http://creativecommons.org/licenses/by-nc/3.0/
10.2174/1874210601509010120
1553505648
https://opendentistryjournal.com/VOLUME/9/PAGE/120/
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