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        <full_title>The Open Dentistry Journal</full_title>
        <abbrev_title>TODENTJ</abbrev_title>
        <issn media_type="print">1874-2106</issn>
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          <title>Growth Hormone and Craniofacial Tissues. An update</title>
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            <given_name>George</given_name>
            <surname>Litsas</surname>
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                <jats:p>Growth hormone is an important regulator of bone homeostasis. In childhood, it determines the longitudinal bone growth, skeletal maturation, and acquisition of bone mass. In adulthood, it is necessary to maintain bone mass throughout life. Although an association between craniofacial and somatic development has been clearly established, craniofacial growth involves complex interactions of genes, hormones and environment. Moreover, as an anabolic hormone seems to have an important role in the regulation of bone remodeling, muscle enhancement and tooth development. In this paper the influence of growth hormone on oral tissues is reviewed.</jats:p>
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        <citation_list>
          <citation key="refR1">
            <journal_title>Endocr Rev.</journal_title>
            <author>Giustina A</author>
            <volume>19</volume>
            <first_page>717</first_page>
            <cYear>1998</cYear>
            <unstructured_citation>
                    Giustina A, Veldhuis JD. 
                    Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. 
                    Endocr Rev  
                    1998; 
                    19
                    : 717-97.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR2">
            <journal_title>Horm Metab Res.</journal_title>
            <author>Slootweg MC</author>
            <volume>25</volume>
            <first_page>335</first_page>
            <cYear>1993</cYear>
            <unstructured_citation>
                    Slootweg MC. 
                    Growth hormone and bone. 
                    Horm Metab Res  
                    1993; 
                    25
                    : 335-43.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR3">
            <journal_title>Acta Endocrinol (Copenh).</journal_title>
            <author>Wuster C</author>
            <first_page>14</first_page>
            <cYear>1993</cYear>
            <unstructured_citation>
                    Wuster C. 
                    Growth hormone and bone metabolism. 
                    Acta Endocrinol (Copenh)  
                    1993; 
                    (Suppl 2
            )
                    14-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR4">
            <journal_title>Endocr Rev.</journal_title>
            <author>Giustina A</author>
            <volume>29</volume>
            <first_page>535</first_page>
            <cYear>2008</cYear>
            <unstructured_citation>
                    Giustina A, Mazziotti G, Canalis E. 
                    Growth hormone, insulin-like growth factors, and the skeleton. 
                    Endocr Rev  
                    2008; 
                    29
                    : 535-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR5">
            <journal_title>Trends Endocrinol Metab.</journal_title>
            <author>Giustina A</author>
            <volume>3</volume>
            <first_page>306</first_page>
            <cYear>1992</cYear>
            <unstructured_citation>
                    Giustina A, Wehrenberg WB. 
                    The role of glucocorticoids in the regulation of growth hormone secretion. 
                    Trends Endocrinol Metab  
                    1992; 
                    3
                    : 306-11.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR6">
            <journal_title>Eur J Endocrinol.</journal_title>
            <author>Giustina A</author>
            <volume>133</volume>
            <first_page>646</first_page>
            <cYear>1995</cYear>
            <unstructured_citation>
                    Giustina A, Wehrenberg WB. 
                    Influence of thyroid hormones on the regulation of growth hormone secretion. 
                    Eur J Endocrinol  
                    1995; 
                    133
                    : 646-53.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR7">
            <journal_title>J Clin Endocrinol Metab.</journal_title>
            <author>Ballesteros M</author>
            <volume>85</volume>
            <first_page>2865</first_page>
            <cYear>2000</cYear>
            <unstructured_citation>
                    Ballesteros M, Leung KC, Ross RJ, Iismaa TP, Ho KK. 
                    Distribution and abundance of messenger ribonucleic acid for growth hormone receptor isoforms in human tissues. 
                    J Clin Endocrinol Metab  
                    2000; 
                    85
                    : 2865-871.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR8">
            <journal_title>Kidney Int.</journal_title>
            <author>Feld S</author>
            <volume>48</volume>
            <first_page>45</first_page>
            <cYear>1995</cYear>
            <unstructured_citation>
                    Feld S, Hirschberg R. 
                    Growth hormone, the insulin-like growth factor system, and the kidney. 
                    Kidney Int  
                    1995; 
                    48
                    : 45-1.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR9">
            <journal_title>Genomics.</journal_title>
            <author>Chen EY</author>
            <volume>4</volume>
            <first_page>479</first_page>
            <cYear>1989</cYear>
            <unstructured_citation>
                    Chen EY, Liao Y-C, Smith DH, Barrera-Saldana HA, Gelinas RE, Seeburg PH. 
                    The human growth hormone locus Nucleotide sequence, biology, and evolution. 
                    Genomics  
                    1989; 
                    4
                    : 479-97.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR10">
            <journal_title>Nature.</journal_title>
            <author>Daughaday WH</author>
            <volume>235</volume>
            <first_page>107</first_page>
            <cYear>1972</cYear>
            <unstructured_citation>
                    Daughaday WH, Hall K, Raben MS , et al. 
                    Somatomedin Proposed designation for sulphation factor. 
                    Nature  
                    1972; 
                    235
                    : 107.
                </unstructured_citation>
          </citation>
          <citation key="refR11">
            <journal_title>Science.</journal_title>
            <author>Isaksson OG</author>
            <volume>216</volume>
            <first_page>1237</first_page>
            <cYear>1982</cYear>
            <unstructured_citation>
                    Isaksson OG, Jansson JO, Gause IA. 
                    Growth hormone stimulates longitudinal bone growth directly. 
                    Science  
                    1982; 
                    216
                    : 1237-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR12">
            <journal_title>Endocr Rev.</journal_title>
            <author>Isaksson OG</author>
            <volume>8</volume>
            <first_page>426</first_page>
            <cYear>1987</cYear>
            <unstructured_citation>
                    Isaksson OG, Lindahl A, Nilsson A, Isgaard J. 
                    Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth. 
                    Endocr Rev  
                    1987; 
                    8
                    : 426-38.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR13">
            <journal_title>Differentiation.</journal_title>
            <author>Green H</author>
            <volume>29</volume>
            <first_page>195</first_page>
            <cYear>1985</cYear>
            <unstructured_citation>
                    Green H, Morikawa M, Nixon T. 
                    A dual effector theory of growth-hormone action. 
                    Differentiation  
                    1985; 
                    29
                    : 195-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR14">
            <journal_title>Endocrinology.</journal_title>
            <author>Barnard R</author>
            <volume>122</volume>
            <first_page>2562</first_page>
            <cYear>1988</cYear>
            <unstructured_citation>
                    Barnard R, Haynes KM, Werther GA, Waters MJ. 
                    The odontogeny of growth hormone receptors in the rabbit tibia. 
                    Endocrinology  
                    1988; 
                    122
                    : 2562-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR15">
            <journal_title> Endocrinology.</journal_title>
            <author>Barnard R</author>
            <volume>128</volume>
            <first_page>1459</first_page>
            <cYear>1991</cYear>
            <unstructured_citation>
                    Barnard R, Ng KW, Martin TJ, Waters MJ. 
                    Growth hormone receptors in clonal osteoblast-like cells mediate a mitogenic response to, GH. 
                     Endocrinology  
                    1991; 
                    128
                    : 1459-64.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR16">
            <journal_title>Calcif Tissue Int.</journal_title>
            <author>Kassem M</author>
            <volume>52</volume>
            <first_page>222</first_page>
            <cYear>1993</cYear>
            <unstructured_citation>
                    Kassem M, Blum W, Ristelli J, Mosekilde L, Eriksen EF. 
                    Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro. 
                    Calcif Tissue Int  
                    1993; 
                    52
                    : 222-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR17">
            <journal_title>J Bone Miner Res.</journal_title>
            <author>Gevers EF</author>
            <volume>17</volume>
            <first_page>1408</first_page>
            <cYear>2002</cYear>
            <unstructured_citation>
                    Gevers EF, van der Eerden BC, Karperien M, Raap AK, Robinson IC, Wit JM. 
                    Localization and regulation of the growth hormone receptor and growth hormone binding protein in the rat growth plate. 
                    J Bone Miner Res  
                    2002; 
                    17
                    : 1408-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR18">
            <journal_title>Acta Paediatr.</journal_title>
            <author>Werther GA</author>
            <volume>82</volume>
            <first_page>50</first_page>
            <cYear>1993</cYear>
            <unstructured_citation>
                    Werther GA, Haynes K, Edmonson S, Oakes S, Buchanan CJ. 
                    Identification of growth hormone receptors on human growth plate chondrocytes. 
                    Acta Paediatr  
                    1993; 
                    82
                    : 50-3.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR19">
            <journal_title>Nature.</journal_title>
            <author>Leung DW</author>
            <volume>330</volume>
            <first_page>537</first_page>
            <cYear>1987</cYear>
            <unstructured_citation>
                    Leung DW, Spencer SA, Cachianes G , et al. 
                    Growth hormone receptor and serum binding protein Purification, cloning and expression. 
                    Nature  
                    1987; 
                    330
                    : 537-43.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR20">
            <journal_title>Genes Dev.</journal_title>
            <author>Hogan BL</author>
            <volume>10</volume>
            <first_page>1580</first_page>
            <cYear>1996</cYear>
            <unstructured_citation>
                    Hogan BL. 
                    Bone morphogenic proteins Multifunctional regulators of vertebrate development. 
                    Genes Dev  
                    1996; 
                    10
                    : 1580-94.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR21">
            <journal_title>Angle Orthod.</journal_title>
            <author>Ong CK</author>
            <volume>71</volume>
            <first_page>486</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Ong CK, Joseph BK, Waters MJ, Symons AL. 
                    Growth hormone receptor and IGF-I receptor immunoreactivity during orthodontic tooth movement in the prednisolone-treated rat. 
                    Angle Orthod  
                    2001; 
                    71
                    (6)
                    : 486-93.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR22">
            <journal_title>Bone.</journal_title>
            <author>Hayden JM</author>
            <volume>17</volume>
            <first_page>93S</first_page>
            <cYear>1995</cYear>
            <unstructured_citation>
                    Hayden JM, Mohan S, Baylink DJ. 
                    The insulin-like growth factor system and the coupling of formation to resorption. 
                    Bone  
                    1995; 
                    17
                    (Suppl 2
    )
                    : 93S-8S.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR23">
            <journal_title>Nat Genet.</journal_title>
            <author>Tsuji K</author>
            <volume>38</volume>
            <first_page>1424</first_page>
            <cYear>2006</cYear>
            <unstructured_citation>
                    Tsuji K, Bandyopadhyay A, Harfe BD , et al. 
                    BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. 
                    Nat Genet  
                    2006; 
                    38
                    : 1424-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR24">
            <journal_title>Endocrinology.</journal_title>
            <author>Ernst M</author>
            <volume>127</volume>
            <first_page>807</first_page>
            <cYear>1990</cYear>
            <unstructured_citation>
                    Ernst M, Rodan GA. 
                    Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): positive correlation with the presence of the GH-induced IGF-binding protein BP-3. 
                    Endocrinology  
                    1990; 
                    127
                    : 807-14.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR25">
            <journal_title>J Bone Miner Res.</journal_title>
            <author>Li H</author>
            <volume>16</volume>
            <first_page>1068</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Li H, Bartold PM, Young WG, Xiao Y, Waters MJ. 
                    Growth hormone induces bone morphogenetic proteins and bone-related proteins in the developing rat periodontium. 
                    J Bone Miner Res  
                    2001; 
                    16
                    (6)
                    : 1068-76.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR26">
            <journal_title>Endocr Rev.</journal_title>
            <author>Ohlsson C</author>
            <volume>19</volume>
            <first_page>55</first_page>
            <cYear>1998</cYear>
            <unstructured_citation>
                    Ohlsson C, Bengtsson BA, Isaksson OGP, Andreassen TT, Slootweg MC. 
                    Growth hormone and bone. 
                    Endocr Rev  
                    1998; 
                    19
                    : 55-79.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR27">
            <journal_title>J Clin Endocrinol Metab.</journal_title>
            <author>Lofqvist C</author>
            <volume>86</volume>
            <first_page>5870</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Lofqvist C, Andersson E, Gelander L, Rosberg S, Blum WF, Albertsson-Wikland K. 
                    Reference values for IGF-I throughout childhood and adolescence A model that accounts simultaneously for the effect of gender, age and puberty. 
                    J Clin Endocrinol Metab  
                    2001; 
                    86
                    : 5870-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR28">
            <journal_title>Bone.</journal_title>
            <author>Ueland T</author>
            <volume>33</volume>
            <first_page>638</first_page>
            <cYear>2003</cYear>
            <unstructured_citation>
                    Ueland T, Odgren PR, Yndestad A , et al. 
                    Growth hormone substitution increases gene expression of members of the IGF family in cortical bone from women with adult onset growth hormone deficiency Relationship with bone turn-over. 
                    Bone  
                    2003; 
                    33
                    : 638-45.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR29">
            <journal_title>Eur J Orthod.</journal_title>
            <author>Tengku BS</author>
            <volume>22</volume>
            <first_page>475</first_page>
            <cYear>2000</cYear>
            <unstructured_citation>
                    Tengku BS, Joseph BK, Harbrow D, Taverne AAR, Symons AL. 
                    Effect of a static magnetic field on orthodontic tooth movement in the rat. 
                    Eur J Orthod  
                    2000; 
                    22
                    : 475-87.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR30">
            <journal_title>Endocrinology.</journal_title>
            <author>Nishiyama K</author>
            <volume>137</volume>
            <first_page>35</first_page>
            <cYear>1996</cYear>
            <unstructured_citation>
                    Nishiyama K, Sugimoto T, Kaji H, Kanatani M, Kobayashi T, Chihara K. 
                    Stimulatory effect of growth hormone on bone resorption and osteoclast differentiation. 
                    Endocrinology  
                    1996; 
                    137
                    : 35-41.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR31">
            <journal_title>Eur J Oral Sci.</journal_title>
            <author>Symons AL</author>
            <volume>111</volume>
            <first_page>503</first_page>
            <cYear>2003</cYear>
            <unstructured_citation>
                    Symons AL. 
                    Reduced growth hormone receptor immunoreactivity in osteoclasts adjacent to the erupting molar in the incisor-absent (osteopetrotic) rat. 
                    Eur J Oral Sci  
                    2003; 
                    111
                    : 503-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR32">
            <journal_title>Calcif Tissue Int.</journal_title>
            <author>Zhang CZ</author>
            <volume>50</volume>
            <first_page>541</first_page>
            <cYear>1992</cYear>
            <unstructured_citation>
                    Zhang CZ, Young WG, Li H, Clayden AM, Garcia- Aragon J, Waters MJ. 
                    Expression of growth hormone receptor by immunocytochemistry in rat molar root formation and alveolar bone remodeling. 
                    Calcif Tissue Int  
                    1992; 
                    50
                    : 541-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR33">
            <unstructured_citation>
                    Favus MJ, Baron R, Eds. 
                    General principles of bone biology Primer on the metabolic bone diseases and disorders of mineral metabolism. 
                    5th ed Washington DC American Society for Bone and Mineral Research.  
                     2003; pp. 
                    1-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR34">
            <journal_title>Endocrinology.</journal_title>
            <author>Sadowski CL</author>
            <volume>142</volume>
            <first_page>3890</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Sadowski CL, Wheeler TT, Wang LH, Sadowski HB. 
                    Regulation of IGF-I and suppressor of cytokine signaling gene expression in C2C12 skeletal muscle cells. 
                    Endocrinology  
                    2001; 
                    142
                    : 3890-900.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR35">
            <journal_title>Eur J Endocrinol.</journal_title>
            <author>Daugaard Jr</author>
            <volume>141</volume>
            <first_page>342</first_page>
            <cYear>1999</cYear>
            <unstructured_citation>
                    Daugaard Jr, Brabnert M, Manhem P , et al. 
                    Effect of 6 months of GH treatment on myosin heavy chain composition in GH-deficient patients. 
                    Eur J Endocrinol  
                    1999; 
                    141
                    : 342-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR36">
            <journal_title>J Clin Invest.</journal_title>
            <author>Mavalli MD</author>
            <volume>120</volume>
            <first_page>4007</first_page>
            <cYear>2010</cYear>
            <unstructured_citation>
                    Mavalli MD, DiGirolamo DJ, Fan Y , et al. 
                    Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice. 
                    J Clin Invest  
                    2010; 
                    120
                    : 4007-20.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR37">
            <journal_title>J Clin Endocrinol Metab.</journal_title>
            <author>Koranyi J</author>
            <volume>86</volume>
            <first_page>4693</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Koranyi J, Svensson J, Gotherstrom G, Sunnerghahen KS. 
                    Baseline characteristics and the effects of five years of GH replacement therapy in adults with GH deficiency of childhood or adulthood onset A comparative, prospective study. 
                    J Clin Endocrinol Metab  
                    2001; 
                    86
                    : 4693-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR38">
            <journal_title>J Clin Endocrinol Metab.</journal_title>
            <author>Gotherstrom G</author>
            <volume>94</volume>
            <first_page>809</first_page>
            <cYear>2009</cYear>
            <unstructured_citation>
                    Gotherstrom G, Elbornsson M, Stibrant-Sunnerhagen K, Bengtsson BA, Johannsson J, Svensson J. 
                    Ten years of growth hormone (GH) replacement normalizes muscle strength in GH-deficient adults. 
                    J Clin Endocrinol Metab  
                    2009; 
                    94
                    : 809-16.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR39">
            <journal_title>Endocrinology.</journal_title>
            <author>Gosteli-Peter MA</author>
            <volume>135</volume>
            <first_page>2558</first_page>
            <cYear>1994</cYear>
            <unstructured_citation>
                    Gosteli-Peter MA, Winterhalter KH, Schmid C, Froesch ER, Zapf J. 
                    Expression and regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone. 
                    Endocrinology  
                    1994; 
                    135
                    : 2558-67.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR40">
            <journal_title>Dev Biol.</journal_title>
            <author>Lupu F</author>
            <volume>229</volume>
            <first_page>141</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Lupu F, Terwilliger JD, Lee K, Segre GV, Efstratiadis A. 
                    Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. 
                    Dev Biol  
                    2001; 
                    229
                    : 141-62.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR41">
            <journal_title>Proc Natl Acad Sci USA.</journal_title>
            <author>Sotiropoulos A</author>
            <volume>103</volume>
            <first_page>7315</first_page>
            <cYear>2006</cYear>
            <unstructured_citation>
                    Sotiropoulos A, Ohanna M, Kedzia C , et al. 
                    Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation. 
                    Proc Natl Acad Sci USA  
                    2006; 
                    103
                    : 7315-20.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR42">
            <journal_title>J Bone Miner Res.</journal_title>
            <author>Frost HM</author>
            <volume>14</volume>
            <first_page>1473</first_page>
            <cYear>1999</cYear>
            <unstructured_citation>
                    Frost HM. 
                    On the estrogen-bone relationship and postmenopausal bone loss A new model. 
                    J Bone Miner Res  
                    1999; 
                    14
                    : 1473-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR43">
            <journal_title>Ann Arbor Center for Human Growth and Develoment University of Michigan.</journal_title>
            <author>McNamara Jr. JA</author>
            <first_page>101</first_page>
            <cYear>1975</cYear>
            <unstructured_citation>
                    McNamara Jr. JA, Petrovic AG, Stutzmann JJ, Oudet CL. 
                    Control processes in the postnatal growth of the condylar cartilage of the mandible Determinants of mandibular form and growth. 
                    Ann Arbor Center for Human Growth and Develoment University of Michigan  
                    1975; 
                    101-54.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR44">
            <journal_title>Dev Biol.</journal_title>
            <author>Solem RC</author>
            <volume>356</volume>
            <first_page>28</first_page>
            <cYear>2011</cYear>
            <unstructured_citation>
                    Solem RC, Eames BF, Tokita M, Schneider RA. 
                    Mesenchymal and mechanical mechanisms of secondary cartilage induction. 
                    Dev Biol  
                    2011; 
                    356
                    : 28-39.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR45">
            <journal_title>J Anat.</journal_title>
            <author>Silbermman M</author>
            <volume>151</volume>
            <first_page>169</first_page>
            <cYear>1987</cYear>
            <unstructured_citation>
                    Silbermman M, Reddi AH, Hand AR, Leapman RD, Von der Mark, Franzen A. 
                    Further characterisation of the extracellular matrix in the mandibular condyle in neonatal mice. 
                    J Anat  
                    1987; 
                    151
                    : 169-88.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR46">
            <journal_title>Endocrinology.</journal_title>
            <author>Lewinson D</author>
            <volume>135</volume>
            <first_page>1504</first_page>
            <cYear>1994</cYear>
            <unstructured_citation>
                    Lewinson D, Bialik GM, Hochberg Z. 
                    Differential effects of hypothyroidism on the cartilage and the osteogenic process in the mandibular condyle Recovery by growth hormone and thyroxine. 
                    Endocrinology  
                    1994; 
                    135
                    : 1504-0.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR47">
            <journal_title>J Dent Res.</journal_title>
            <author>Visnapuu V</author>
            <volume>80</volume>
            <first_page>1903,</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Visnapuu V, Peltomäki T, Rönning O, Vahlberg T, Helenius H. 
                    Growth hormone and Insulin-like growth factor I receptors in the temporomandibular joint of the rat. 
                    J Dent Res  
                    2001; 
                    80
                    : 1903,-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR48">
            <journal_title>Endocrinology.</journal_title>
            <author>Maor G</author>
            <volume>125</volume>
            <first_page>1239</first_page>
            <cYear>1989</cYear>
            <unstructured_citation>
                    Maor G, Hochberg Z, Von der Mark K, Heinegard D, Silbermann M. 
                    Human growth hormone enhances chondrogenesis and osteogenesis in a tissue culture system of chondroprogenitor cells. 
                    Endocrinology  
                    1989; 
                    125
                    : 1239-45.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR49">
            <journal_title>J Craniofac Genet Dev Biol.</journal_title>
            <author>Pirinen S</author>
            <volume>14</volume>
            <first_page>144</first_page>
            <cYear>1994</cYear>
            <unstructured_citation>
                    Pirinen S, Majurin A, Lenko HL Koski K. 
                    Craniofacial features in patients with deficient and excessive growth hormone. 
                    J Craniofac Genet Dev Biol  
                    1994; 
                    14
                    : 144-52.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR50">
            <journal_title>Arch Oral Biol.</journal_title>
            <author>Ramirez-Yañez GO</author>
            <volume>49</volume>
            <first_page>585</first_page>
            <cYear>2004</cYear>
            <unstructured_citation>
                    Ramirez-Yañez GO, Young WG, Daley TJ, Waters MJ. 
                    Influence of growth hormone on the mandibular condylar cartilage of rats. 
                    Arch Oral Biol  
                    2004; 
                    49
                    : 585-90.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR51">
            <journal_title>J Clin Endocrinol Metab.</journal_title>
            <author>Laron Z</author>
            <volume>89</volume>
            <first_page>1031</first_page>
            <cYear>2004</cYear>
            <unstructured_citation>
                    Laron Z. 
                    Laron syndrome (primary growth hormone resistance or insensitivity): The personal experience 1958 - 2003. 
                    J Clin Endocrinol Metab  
                    2004; 
                    89
                    : 1031-44.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR52">
            <journal_title>Am J Orthod Dentofacial Orthop.</journal_title>
            <author>Yamaguchi T</author>
            <volume>119</volume>
            <first_page>650</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Yamaguchi T, Maki K, Shibasaki Y. 
                    Growth hormone receptor gene variant and mandibular height in the normal Japanese population. 
                    Am J Orthod Dentofacial Orthop  
                    2001; 
                    119
                    : 650-3.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR53">
            <journal_title>J Dent Res.</journal_title>
            <author>Zhou J</author>
            <volume>84</volume>
            <first_page>1052</first_page>
            <cYear>2005</cYear>
            <unstructured_citation>
                    Zhou J, Lu Y, Gao XH , et al. 
                    The growth hormone receptor gene is associated with mandibular height in a Chinese population. 
                    J Dent Res  
                    2005; 
                    84
                    : 1052-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR54">
            <journal_title>Am J Orthod Dentofacial Orthop.</journal_title>
            <author>Tomoyasu Y</author>
            <volume>136</volume>
            <first_page>536</first_page>
            <cYear>2009</cYear>
            <unstructured_citation>
                    Tomoyasu Y, Yamaguchi T, Tajima A, Nakajima T, Inoue I, Maki K. 
                    Further evidence for an association between mandibular height and the growth hormone receptor gene in a Japanese population. 
                    Am J Orthod Dentofacial Orthop  
                    2009; 
                    136
                    : 536-41.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR55">
            <journal_title>Arch Oral Biol.</journal_title>
            <author>Kang EH</author>
            <volume>54</volume>
            <first_page>556</first_page>
            <cYear>2009</cYear>
            <unstructured_citation>
                    Kang EH, Yamaguchi T, Tajima A , et al. 
                    Association of the growth hormone receptor gene polymorphisms with mandibular height in a Korean population. 
                    Arch Oral Biol  
                    2009; 
                    54
                    : 556-62.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR56">
            <journal_title>Eur J Orthod.</journal_title>
            <author>Sasaki Y</author>
            <volume>31</volume>
            <first_page>536</first_page>
            <cYear>2009</cYear>
            <unstructured_citation>
                    Sasaki Y, Satoh K, Hayasaki H, Fukumoto S, Fujiwara T, Nonaka K. 
                    The P561T polymorphism of the growth hormone receptor gene has an inhibitory effect on mandibular growth in young children. 
                    Eur J Orthod  
                    2009; 
                    31
                    : 536-41.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR57">
            <journal_title>J Dent Res.</journal_title>
            <author>Young WG</author>
            <volume>71</volume>
            <first_page>1807</first_page>
            <cYear>1992</cYear>
            <unstructured_citation>
                    Young WG, Zhang CZ Li H, Osborne P, Waters MJ. 
                    The influence of growth hormone on cell proliferation in odontogenic epithelia by bromodeoxyuridine immunocytochemistry and morphometry in the Lewis dwarf rat. 
                    J Dent Res  
                    1992; 
                    71
                    : 1807-1.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR58">
            <journal_title>Growth Fact.</journal_title>
            <author>Zhang CZ</author>
            <volume>14</volume>
            <first_page>131</first_page>
            <cYear>1997</cYear>
            <unstructured_citation>
                    Zhang CZ, Li H, Young WG, Bartold PM, Chen C, Waters MJ. 
                    Evidence for a local action of growth hormone in embryonic tooth development in the rat. 
                    Growth Fact  
                    1997; 
                    14
                    : 131-43.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR59">
            <journal_title>Arch Oral Biol.</journal_title>
            <author>Young WG</author>
            <volume>40</volume>
            <first_page>789</first_page>
            <cYear>1995</cYear>
            <unstructured_citation>
                    Young WG, Rush JV, Stevens MR , et al. 
                    Comparison of the effects of growth hormone, insulin like factor-I and fetal calf serum on mouse molar odontogenesis in vitro. 
                    Arch Oral Biol  
                    1995; 
                    40
                    : 789-99.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR60">
            <journal_title>Eur J Oral Sci.</journal_title>
            <author>Tabata MJ</author>
            <volume>110</volume>
            <first_page>114</first_page>
            <cYear>2002</cYear>
            <unstructured_citation>
                    Tabata MJ, Fujii T, Liu JG , et al. 
                    Bone morphogenetic protein 4 is involved in cusp formation in molar tooth germ of mice. 
                    Eur J Oral Sci  
                    2002; 
                    110
                    : 114-21.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR61">
            <journal_title>J Dent Res.</journal_title>
            <author>Smid Jr</author>
            <volume>83</volume>
            <first_page>35</first_page>
            <cYear>2004</cYear>
            <unstructured_citation>
                    Smid Jr, Rowland JE, Young WG , et al. 
                    Mouse cellular cementum is highly dependent on growth hormone status. 
                    J Dent Res  
                    2004; 
                    83
                    : 35-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR62">
            <journal_title>J Dent Res.</journal_title>
            <author>Smid Jr</author>
            <volume>86</volume>
            <first_page>463</first_page>
            <cYear>2007</cYear>
            <unstructured_citation>
                    Smid Jr, Rowland JE, Young WG, Coschigano KT, Kopchick JJ, Waters MJ. 
                    Mouse molar dentin size/shape is dependent on growth hormone status. 
                    J Dent Res  
                    2007; 
                    86
                    : 463-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR63">
            <journal_title>Oral Surg Oral Med Oral Pathol.</journal_title>
            <author>Sarnat H</author>
            <volume>66</volume>
            <first_page>581</first_page>
            <cYear>1988</cYear>
            <unstructured_citation>
                    Sarnat H, Kaplan I, Petzelan A, Laron Z. 
                    Comparison of dental findings in patients with isolated growth hormone deficiency treated with human growth hormone (hGH) and in untreated patients with Laron-type dwarfism. 
                    Oral Surg Oral Med Oral Pathol  
                    1988; 
                    66
                    : 581-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR64">
            <journal_title>J Biol Bucc.</journal_title>
            <author>Bigeard L</author>
            <volume>19</volume>
            <first_page>291</first_page>
            <cYear>1991</cYear>
            <unstructured_citation>
                    Bigeard L, Sommermater J. 
                    Retard dentaire et microdonfii chez I'enfant atteint de deficit en hormone somatotrope. 
                    J Biol Bucc  
                    1991; 
                    19
                    : 291-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR65">
            <journal_title>Eur J Oral Sci.</journal_title>
            <author>Krekmanova L</author>
            <volume>105</volume>
            <first_page>551</first_page>
            <cYear>1997</cYear>
            <unstructured_citation>
                    Krekmanova L, Bronnegard M, Marcus C, Grondahl E, Modeer T, Dahloff G. 
                    Dental maturity in children of short stature, with or without growth hormone deficiency. 
                    Eur J Oral Sci  
                    1997; 
                    105
                    : 551-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR66">
            <journal_title>Acta Odont Scand.</journal_title>
            <author>Krekmanova L</author>
            <volume>57</volume>
            <first_page>93</first_page>
            <cYear>1999</cYear>
            <unstructured_citation>
                    Krekmanova L, Carlstedt-Duke C, Marcus C, Dahloff G. 
                    Dental maturity in children of short stature--a two-year longitudinal study of growth hormone substitution. 
                    Acta Odont Scand  
                    1999; 
                    57
                    : 93-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR67">
            <journal_title>Eur J Oral Sci.</journal_title>
            <author>Kjellberg H</author>
            <volume>108</volume>
            <first_page>359</first_page>
            <cYear>2000</cYear>
            <unstructured_citation>
                    Kjellberg H, Beiring M, Albertsson Wikland K. 
                    Craniofacial morphology, dental occlusion, tooth eruption, and dental maturity in boys of short stature with or without growth hormone deficiency. 
                    Eur J Oral Sci  
                    2000; 
                    108
                    : 359-67.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR68">
            <journal_title>Am J Orthod Dentofacial Orthop.</journal_title>
            <author>Ito RK</author>
            <volume>103</volume>
            <first_page>358</first_page>
            <cYear>1993</cYear>
            <unstructured_citation>
                    Ito RK, Vig KW, Garn SM , et al. 
                    The influence of growth hormone (rhGH) therapy on tooth formation in idiopathic short statured children. 
                    Am J Orthod Dentofacial Orthop  
                    1993; 
                    103
                    : 358-64.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR69">
            <journal_title>J Clin Endocrinol Metab.</journal_title>
            <author>Schweizer R</author>
            <volume>88</volume>
            <first_page>5266</first_page>
            <cYear>2003</cYear>
            <unstructured_citation>
                    Schweizer R, Martin DD, Schwarze CP , et al. 
                    Cortical bone density is normal in prepubertal children with growth hormone deficiency, but initially decreases during GH replacement due to early bone remodeling. 
                    J Clin Endocrinol Metab  
                    2003; 
                    88
                    : 5266-72.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR70">
            <journal_title>J Bone Miner Metab.</journal_title>
            <author>Iglesias L</author>
            <volume>29</volume>
            <first_page>159</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Iglesias L, Yeh JK, Castro Magana M, Aloia JF. 
                    Effects of growth hormone on bone modeling and remodeling in hypophysectomized young female rats A bone histomorphometric study. 
                    J Bone Miner Metab  
                    2001; 
                    29
                    : 159-67.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR71">
            <journal_title>J Endocrinol Invest.</journal_title>
            <author>Baroncelli GI</author>
            <volume>10</volume>
            <first_page>23</first_page>
            <cYear>2005</cYear>
            <unstructured_citation>
                    Baroncelli GI, Saggese G. 
                    Effect of GH treatment on bone mass in children with GH deficiency. 
                    J Endocrinol Invest  
                    2005; 
                    10
                    : 23-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR72">
            <journal_title>Implant Dent.</journal_title>
            <author>Eldein HAM</author>
            <volume>20</volume>
            <first_page>47</first_page>
            <cYear>2011</cYear>
            <unstructured_citation>
                    Eldein HAM, Elghamrawy SH, Osman SM, Elhak AR. 
                    Histological evaluation of the effect of using growth hormone around immediate dental implants in fresh extraction sockets An experimental study. 
                    Implant Dent  
                    2011; 
                    20
                    (1)
                    : 47-55.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR73">
            <journal_title>Clin Oral Implants Res.</journal_title>
            <author>Calvo-Guirado JL</author>
            <volume>22</volume>
            <first_page>587</first_page>
            <cYear>2011</cYear>
            <unstructured_citation>
                    Calvo-Guirado JL, Mate-Sanchez J, Delgado-Ruiz R, Ramirez-Fernández MP, Cutando-Soriano A, Peña M. 
                    Effects of growth hormone on initial bone formation around dental implants A dog study. 
                    Clin Oral Implants Res  
                    2011; 
                    22
                    (6)
                    : 587-93.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR74">
            <journal_title>Shanghai Kou Qiang Yi Xue.</journal_title>
            <author>Zhang J1</author>
            <volume>15</volume>
            <first_page>521</first_page>
            <cYear>2006</cYear>
            <unstructured_citation>
                    Zhang J1, Wang SL, Wang XX, Huang Y, Zhang WJ. 
                    Effects of rh-GH on the remodeling of periodontium in the ovariectomized rats after orthodontic tooth movement. 
                    Shanghai Kou Qiang Yi Xue  
                    2006; 
                    15
                    : 521-.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR75">
            <journal_title>J Bone Miner Res.</journal_title>
            <author>Forwood MR</author>
            <volume>16</volume>
            <first_page>2284</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Forwood MR, Li L, Kelly WL, Bennett MB. 
                    Growth hormone is permissive for skeletal adaptation to mechanical loading. 
                    J Bone Miner Res  
                    2001; 
                    16
                    : 2284-90.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR76">
            <journal_title>J Appl Phys.</journal_title>
            <author>Boudignon BM</author>
            <volume>103</volume>
            <first_page>125</first_page>
            <cYear>2007</cYear>
            <unstructured_citation>
                    Boudignon BM, Bikle DD, Kurimoto P , et al. 
                    Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading. 
                    J Appl Phys  
                    2007; 
                    103
                    : 125-31.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR77">
            <journal_title>J Clin Endocrinol Metab.</journal_title>
            <author>Vanderschueren D</author>
            <volume>91</volume>
            <first_page>378</first_page>
            <cYear>2006</cYear>
            <unstructured_citation>
                    Vanderschueren D, Venken K, Ophoff J, Bouillon R, Boonen S. 
                    Clinical Review Sex steroids and the periosteum-reconsidering the roles of androgens and estrogens in periosteal expansion. 
                    J Clin Endocrinol Metab  
                    2006; 
                    91
                    : 378-82.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR78">
            <journal_title>J Clin Endocrinol Metab.</journal_title>
            <author>Short KR</author>
            <volume>93</volume>
            <first_page>597</first_page>
            <cYear>2008</cYear>
            <unstructured_citation>
                    Short KR, Moller N, Bigelow ML, Coenen-Schimke J, Nair KS. 
                    Enhancement of muscle mitochondrial function by growth hormone. 
                    J Clin Endocrinol Metab  
                    2008; 
                    93
                    (2)
                    : 597-604.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR79">
            <journal_title>Growth Dev Aging.</journal_title>
            <author>Everitt AV</author>
            <volume>60</volume>
            <first_page>85</first_page>
            <cYear>1996</cYear>
            <unstructured_citation>
                    Everitt AV, Terry V, Phillips MJ, Kerry HM, Shorey CD. 
                    Morphometric analysis of gastrocnemius muscle fiber size and fiber proportions in the hypophysectomized rat after prolonged administration of growth hormone or thyroxine. 
                    Growth Dev Aging  
                    1996; 
                    60
                    : 85-93.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR80">
            <journal_title>Calcif Tissue Int.</journal_title>
            <author>Livne E</author>
            <volume>61</volume>
            <first_page>62</first_page>
            <cYear>1997</cYear>
            <unstructured_citation>
                    Livne E, Laufer D, Blumenfeld I. 
                    Comparison of in vitro response to growth hormone by chondrocytes from mandibular condyle cartilage of young and old mice. 
                    Calcif Tissue Int  
                    1997; 
                    61
                    : 62-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR81">
            <journal_title>Adv Dent Res.</journal_title>
            <author>Thesleff I</author>
            <volume>15</volume>
            <first_page>14</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Thesleff I, Keranen S, Jernvall J. 
                    Enamel Knots as signaling centers linking tooth morphogenesis and odontoblast differentiation. 
                    Adv Dent Res  
                    2001; 
                    15
                    : 14-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR82">
            <journal_title>Cell.</journal_title>
            <author>Vainio S</author>
            <volume>75</volume>
            <first_page>45</first_page>
            <cYear>1993</cYear>
            <unstructured_citation>
                    Vainio S, Karavanova I, Jowett A, Thesleff I. 
                    Identification of BMP-4 as a signal mediating secondary induction beteen epithelial and mesenchymal tissues during early tooth development. 
                    Cell  
                    1993; 
                    75
                    : 45-58.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR83">
            <journal_title>J Dent Res </journal_title>
            <author>Van Erum R</author>
            <volume>76</volume>
            <first_page>1579</first_page>
            <cYear>997a</cYear>
            <unstructured_citation>
                    Van Erum R, Mulier M, Carels C, Verbeke G, de Zegher F. 
                    Craniofacial growth in short children born small for gestational age Effect of growth hormone treatment. 
                    J Dent Res   
                    997a; 
                    76
                    : 1579-86.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR84">
            <journal_title>J Craniofac Genet Dev Biol.</journal_title>
            <author>Van Erum R</author>
            <volume>17</volume>
            <first_page>184</first_page>
            <cYear>1997</cYear>
            <unstructured_citation>
                    Van Erum R, Carels C, Verbeke G, de Zegher F. 
                    Craniofacial growth in short children born small for gestational age Two years follow-up after high-dose growth hormone treatment. 
                    J Craniofac Genet Dev Biol  
                    1997; 
                    17
                    : 184-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR85">
            <journal_title>Oral Dis.</journal_title>
            <author>Litsas G</author>
            <volume>19</volume>
            <first_page>559</first_page>
            <cYear>2013</cYear>
            <unstructured_citation>
                    Litsas G. 
                    Growth hormone therapy and craniofacial bones A comprehensive review. 
                    Oral Dis  
                    2013; 
                    19
                    : 559-67.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR86">
            <journal_title>Eur J Orthod.</journal_title>
            <author>Kjellberg H</author>
            <volume>29</volume>
            <first_page>243</first_page>
            <cYear>2007</cYear>
            <unstructured_citation>
                    Kjellberg H, Wikland KA. 
                    A longitudinal study of craniofacial growth in idiopathic short stature and growth hormone-deficient boys treated with growth hormone. 
                    Eur J Orthod  
                    2007; 
                    29
                    : 243-50.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR87">
            <journal_title>Angle Orthod.</journal_title>
            <author>Funatsu M</author>
            <volume>76</volume>
            <first_page>970</first_page>
            <cYear>2006</cYear>
            <unstructured_citation>
                    Funatsu M, Sato K, Mitani H. 
                    Effects of growth hormone on craniofacial growth. 
                    Angle Orthod  
                    2006; 
                    76
                    : 970-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR88">
            <journal_title>Am J Orthod Dentofacial Orthop.</journal_title>
            <author>Hwang CJ</author>
            <volume>126</volume>
            <first_page>118</first_page>
            <cYear>2004</cYear>
            <unstructured_citation>
                    Hwang CJ, Cha JY. 
                    Orthodontic treatment with growth hormone therapy in a girl of short stature. 
                    Am J Orthod Dentofacial Orthop  
                    2004; 
                    126
                    : 118-26.
                    
                </unstructured_citation>
          </citation>
        </citation_list>
      </journal_article>
    </journal>
  </body>
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