TODENTJ-25-03-2019_TODENTJ-8-136 1553505544 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 9 8 2014 8 1 Auerkari E.I Joewono V Handjari D.R Sarwono A.T Suhartono A.W Eto K Ikeda M.A Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27Kip1 has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27Kip1 with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27Kip1 suggests that also in combination these would not help to better predict the outcome of HNSCC. 9 8 2014 136 143 TODENTJ-8-136 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2014-4-28 2014-6-27 2014-7-1 2014-9-8 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601408010136 1553505544 https://opendentistryjournal.com/VOLUME/8/PAGE/136/ https://opendentistryjournal.com/contents/volumes/V8/TODENTJ-8-136/TODENTJ-8-136.pdf https://opendentistryjournal.com/contents/volumes/V8/TODENTJ-8-136/TODENTJ-8-136.pdf https://opendentistryjournal.com/contents/volumes/V8/TODENTJ-8-136/TODENTJ-8-136.pdf https://opendentistryjournal.com/contents/volumes/V8/TODENTJ-8-136/TODENTJ-8-136.pdf https://opendentistryjournal.com/contents/volumes/V8/TODENTJ-8-136/TODENTJ-8-136.pdf https://opendentistryjournal.com/contents/volumes/V8/TODENTJ-8-136/TODENTJ-8-136.pdf https://opendentistryjournal.com/contents/volumes/V8/TODENTJ-8-136/TODENTJ-8-136.pdf https://opendentistryjournal.com/contents/volumes/V8/TODENTJ-8-136/TODENTJ-8-136.xml Nat Rev Cancer. Friedl P 3 362 2002 Friedl P, Wolf K. Tumor-cell invasion and migration diversity and escape mechanisms. Nat Rev Cancer 2002; 3 : 362-74. Ann Oncol. Boyle P 16 481 2005 Boyle P, Ferlay J. Cancer incidence and mortality in Europe, 2004,. Ann Oncol 2005; 16 : 481-8. Ann Oncol. Bosetti C 16 489 2005 Bosetti C, Malvezzi M, Chatenoud L, Negri E, Levi F, La Vecchia C. Trends in cancer mortality in the Americas, 1970,-2000,. Ann Oncol 2005; 16 : 489-511. Nature Rev Cancer. Hunter KD 5 127 2005 Hunter KD, Parkinson EK, Harrison PR. Profiling early head and neck cancer. Nature Rev Cancer 2005; 5 : 127-35. Crit Rev Oral Biol Med. Wong DTW 7 319 1996 Wong DTW, Todd R, Tsuji T, Donoff RB. Molecular biology of human oral cancer. Crit Rev Oral Biol Med 1996; 7 (4) : 319-28. Scand J Dent Res. Anneroth G 95 229 1987 Anneroth G, Batsakis J, Luna M. Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Scand J Dent Res 1987; 95 : 229-48. Nature. Venkitaraman AR 434 829 2005 Venkitaraman AR. Aborting the birth of cancer. Nature 2005; 434 : 829-30. Nature Genet. Roepman P 37 182 2005 Roepman P, Wessels LF A, Kettelarij N , et al. Holstege F.C. P. An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nature Genet 2005; 37 : 182-6. Cancer. Mineta H 85 1011 1999 Mineta H, Miura K, Suzuki I , et al. Low p27 expression correlates with poor prognosis for patients with oral tongue squamous cell carcinoma. Cancer 1999; 85 (5) : 1011-7. Cancer. Takata T 86 928 1999 Takata T, Kudo Y, Zhao M , et al. Reduced expression of p27Kip1 protein in relation to salivary adenoid cyctic carcinoma metastasis. Cancer 1999; 86 (6) : 928-35. Nature Cell Biol. Bartek J 3 E95 2001 Bartek J, Lukas J. p27 destruction Cks1 pulls the trigger. Nature Cell Biol 2001; 3 : E95-8. Cancer. Oka K 88 2766 2000 Oka K, Suzuki Y, Nakano T. Expression of p27 and p53 in cervical squamous cell carcinoma patients treated with radiotherapy alone. Cancer 2000; 88 (12) : 2766-73. Int J Cancer. Yao J 89 213 2000 Yao J, Eu KW, Seow-Choen F, Cheah PY. Down-regulation of p27 is a significant predictor of poor overall survival and may facilitate metastasis in colorectal carcinomas. Int J Cancer 2000; 89 : 213-6. Laryngoscope. Fan GK 109 815 1999 Fan GK, Fujieda S, Sunaga H, Tsuzuki H, Ito N, Saito H. Expression of protein p27 is associated with progression and prognosis in laryngeal cancer. Laryngoscope 1999; 109 : 815-20. Amer J Pathol. Florenes VA 153 305 1998 Florenes VA, Maelandsmo GM, Kerbel RS, Slingerland JM, Nesland JM, Holm R. Protein expression of the cell-cycle inhibitor p27Kip1 in malignant melanoma. Amer J Pathol 1998; 153 (1) : 305-12. Cancer. Feakins RM 89 1684 2000 Feakins RM, Mulcahy HE, Quaglia A, Jawhari A, Zhang Z, Patchett SE. p27Kip1 loss does not predict survival in patients with advanced gastric carcinoma. Cancer 2000; 89 : 1684-91. J Cell Biol. St.Croix B 142 557 1998 St.Croix B, Sheehan C, Rak JW, Florenes VA, Slingerland JM, Kerbel RS. E-cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27Kip1. J Cell Biol 1998; 142 (2) : 557-71. J Pathol. Takes RP 194 298 2001 Takes RP, Baatenburg de Jong RJ, Wijffels K , et al. Expression of genetic markers in lymph node metastases compared with their primary tumours in head and neck cancer. J Pathol 2001; 194 : 298-302. J Cell Biol. Hermisto ML 129 489 1995 Hermisto ML, Gordon JI. In vivo analysis of cadherin function in the mouse intestinal epithelium essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J Cell Biol 1995; 129 (2) : 489-506. Oncogene. Berx G 13 1919 1996 Berx G, Cleton-Jansen AM, Strumane K , et al. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. Oncogene 1996; 13 : 1919-25. Int J Cancer. Woo DK 95 108 2001 Woo DK, Kim HK, Lee HS, Kang YH, Yang HK, Kim WH. Altered expression and mutation of β-catenin gene in gastric carcinomas and cell lines. Int J Cancer 2001; 95 : 108-13.