TODENTJ-25-03-2019_TODENTJ-7-169 1553505497 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 11 29 2013 7 1 Montebugnoli Lucio Gabusi Andrea Gissi Davide Bartolomeo Cervellati Fabio Servidio Dora Objective: The present study assessed patients with multiple oral lesions to evaluate the mis-estimation rate in terms of diagnosis and risk of malignant transformation when only one biopsy is performed. Study Design: Thirty-five patients presenting at least two white and/or red lesions in different oral mucosa sites with a final diagnosis of leuko/erythroplakias or lichenoid lesions were included, for a total of 70 biopsies. Results: Nineteen patients (54%) had at least one between-lesion discrepancy considering the presence/absence of dysplasia (10 patients), normal/high cell turnover (13 patients) or diagnosis (5 patients). Discrepancies were not related to clinical aspect or within-patient similarity of lesions. Conclusions: Multiple oral lesions in the same patient can significantly differ in terms of dysplasia, high cell turnover and, even diagnosis. Multiple biopsies are imperative and diagnosis as well as risk of malignant transformation should be formulated for each single lesion rather than for each individual patient. 11 29 2013 169 174 TODENTJ-7-169 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2013-7-11 2013.-9-11 2013-10-26 2013-11-29 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601307010169 1553505497 https://opendentistryjournal.com/VOLUME/7/PAGE/169/ https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-169/TODENTJ-7-169.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-169/TODENTJ-7-169.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-169/TODENTJ-7-169.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-169/TODENTJ-7-169.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-169/TODENTJ-7-169.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-169/TODENTJ-7-169.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-169/TODENTJ-7-169.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-169/TODENTJ-7-169.xml J Oral Pathol Med Warnakulasuriya S 36 575 2007 Warnakulasuriya S, Johnson NW, van der Waal I. 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