TODENTJ-25-03-2019_TODENTJ-7-102 1553505472 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 8 23 2013 7 1 Steffen Mickenautsch Veerasamy Yengopal Purpose: The null-hypothesis that retention loss of resin fissure sealants predicts caries manifestation no more accurately than random values was tested. Methods: Systematic reviews were checked and electronic databases searched for clinical trials. Trials reporting on the retention of resin sealants and caries occurrence in permanent molar teeth, with minimum 24-month follow-up period, were included. Extracted data: number of sealed teeth, number of teeth without completely retained sealants, number of sealed teeth with caries. The number of teeth with complete sealant retention and absence of carious lesions/cavities was calculated; the predictive outcomes: true/false positive; false/true negative were established. Random values were generated as control-data. Diagnostic Odds ratios (DOR) were computed and tested for statistical difference. Summary Receiver Operating Characteristic curves were plotted. Results: 95 trials were found. Median DOR values were 1.21 and 0.28 for test- and control data, respectively. Wilcoxon test (z = 0.56; p = 0.58) and Sign test (z = 1.38; p = 0.17) results were statistically non-significant. The null-hypothesis was not rejected. Conclusions: Predictions based on the retention loss of resin sealants, regarding caries manifestation, was no more accurate than random guesses. Sealant retention loss appears not to be a valid predictor for clinical outcome. 8 23 2013 102 108 TODENTJ-7-102 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2013-3-1 2013-4-25 2013-4-28 2013-8-23 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/18742106201305130001 1553505472 https://opendentistryjournal.com/VOLUME/7/PAGE/102/ https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-102/TODENTJ-7-102.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-102/TODENTJ-7-102.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-102/TODENTJ-7-102.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-102/TODENTJ-7-102.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-102/TODENTJ-7-102.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-102/TODENTJ-7-102.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-102/TODENTJ-7-102.pdf https://opendentistryjournal.com/contents/volumes/V7/TODENTJ-7-102/TODENTJ-7-102.xml Caries Res Splieth CH 44 3 2010 Splieth CH, Ekstrand KR, Alkilzy M, et al. 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