Bisphosphonate-Associated Osteonecrosis of the Jaw: Are We Dealing with a Localized Non-Traditional Calciphylaxis?

TODENTJ-25-03-2019_TODENTJ-6-5 1553505308 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 1 12 2012 6 1 Bisphosphonate-Associated Osteonecrosis of the Jaw: Are We Dealing with a Localized Non-Traditional Calciphylaxis? TF Meiller H Almubarak DS Weikel J Brahim MA Scheper The bisphosphonate (BP) family of drugs has been used as a vital component in cancer therapy and many other diseases. One of the main adverse effects related to (BP) is BP-associated osteonecrosis of the jaw (ONJ). Although this condition was first recognized in 2003, the pathophysiologic mechanism remains undefined. Our hypothesis is that ONJs clinical course and delayed wound healing is in part correlated to a localized non-traditional calciphylaxis. This effect is identified by the evidence of calcium deposition in the connective tissue and around small blood vessels in the soft tissues immediately adjacent to ONJ lesions. This phenomenon helps to fill gaps in the cascade of events which leads to soft tissue ischemia, necrosis, and non-healing ONJ lesions. Our finding adds to the current knowledge of the potential pathophysiologic mechanisms related to ONJ. 1 12 2012 5 7 TODENTJ-6-5 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2011-10-15 2011-11-21 2011-11-22 2012-1-12 http://creativecommons.org/ licenses/by-nc/3.0/ 10.2174/1874210601206010005 1553505308 https://opendentistryjournal.com/VOLUME/6/PAGE/5/ https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-5/TODENTJ-6-5.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-5/TODENTJ-6-5.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-5/TODENTJ-6-5.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-5/TODENTJ-6-5.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-5/TODENTJ-6-5.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-5/TODENTJ-6-5.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-5/TODENTJ-6-5.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-5/TODENTJ-6-5.xml J Craniofac Surg Knight RJ 21 25 2010 Knight RJ, Reddy C, Rtshiladze MA, Lvoff G, Sherring D, Marussi D. 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