TODENTJ-25-03-2019_TODENTJ-6-220 1553505417 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 12 28 2012 6 1 Emanuel Braga Rego Takashi Takata Kazuo Tanne Eiji Tanaka Over the past few years, tissue engineering applied to the dental field has achieved relevant results. Tissue engineering can be described by actions taken to improve biological functions. Several methods have been described to enhance cellular performance and low intensity pulsed ultrasound (LIPUS) has shown to play an important role in cell metabolism. The present article provides an overview about the current status of LIPUS as a tissue engineering tool to be used to enhance tooth and periodontal regeneration. 12 28 2012 220 225 TODENTJ-6-220 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2012-7-5 2012-8-10 2012-9-27 2012-12-28 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601206010220 1553505417 https://opendentistryjournal.com/VOLUME/6/PAGE/220/ https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-220/TODENTJ-6-220.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-220/TODENTJ-6-220.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-220/TODENTJ-6-220.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-220/TODENTJ-6-220.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-220/TODENTJ-6-220.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-220/TODENTJ-6-220.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-220/TODENTJ-6-220.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-220/TODENTJ-6-220.xml J Biomech Petrtyl M 29 1619 1996 Petrtyl M, Hert J, Fiala P. Spatial organization of the haversian bone in man J Biomech 1996; 29 : 1619. Bone Burr DB 18 40510 1996 Burr DB, Milgrom C, Fyhrie D, Forwood M, Nyska M, Finestone A. In vivo measurement of human tibial strains during vigorous activity Bone 1996; 18 : 40510. J Bone Miner Res Everts V 17 77 2002 Everts V, Delaisse JM, Korper W, Jansen DC, Tigchelaar-Gutter W, Beertsen W. The bone lining cell: Its role in cleaning Howship’s lacunae and initiating bone formation J Bone Miner Res 2002; 17 : 77-90. J Bone Miner Res Smit TH 15 301 2000 Smit TH, Burger EH. Is BMU-coupling a strain-regulated phenomenon? a finite element analysis J Bone Miner Res 2000; 15 : 301-7. J Bone Miner Res Smit TH 17 2021 2002 Smit TH, Burger EH, Huyghe JM. A case for strain-induced fluid flow as a regulator of BMU-coupling and osteonal alignment J Bone Miner Res 2002; 17 : 2021-9. Am J Orthod Dentofacial Ortho Masella RS 129 458 2006 Masella RS, Meister M. Current concepts in the biology of orthodontic tooth movement Am J Orthod Dentofacial Ortho 2006; 129 : 458-68. J Dent Res Tan SD 88 255 2009 Tan SD, Xie R, Klein-Nulend J, et al. Orthodontic force stimulates eNOS and iNOS in rat osteocytes J Dent Res 2009; 88 : 255-60. Bone Miner Buckley MJ 4 225 1998 Buckley MJ, Banes AJ, Levin LG, et al. Osteoblasts increase their rate of division and align in response to cyclic mechanical tension in vitro Bone Miner 1998; 4 : 225-36. Prog Biophys Mol Biol Claes L 93 384 2007 Claes L, Willie B. The enhancement of bone regeneration by ultrasound Prog Biophys Mol Biol 2007; 93 : 384-98. J Bone Joint Surg Khan Y 90 138 2008 Khan Y, Laurencin CT. Fracture repair with ultrasound: clinical and cell-based evaluation J Bone Joint Surg 2008; 90 : 138-44. Ultrasound Med Biol Romano CL 35 529 2009 Romano CL, Romano D, Logoluso N. Low-intensity pulsed ultrasound for the treatment of bone delayed union or nonunion: a review Ultrasound Med Biol 2009; 35 : 529-36. J Bone Miner Res Young SR 3 411 2009 Young SR, Gerard-O'Riley R, Kim JB, Pavalko FM. Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts J Bone Miner Res 2009; 3 : 411-24. Arch Orthop Trauma Surg Duarte LR 101 153 1983 Duarte LR. The stimulation of bone growth by ultrasound Arch Orthop Trauma Surg 1983; 101 : 153-9. Dyson M. Eds Therapeutic applications of ultrasound In: Nyborg WL, Ziskin MC, Eds. Biological effects of ultrasound. New York, NY: Churchill Livingstone 1985; pp. 121-33. Ann Biomed Eng El-Bialy TH 30 1251 2002 El-Bialy TH, Royston TJ, Magin RL, Evans CA, ZakiAel M, Frizzell LA. The effect of pulsed ultrasound on mandibular distraction Ann Biomed Eng 2002; 30 : 1251-61. J Pediatr Orthop Gebauer D 6 750 2005 Gebauer D, Correll J. Pulsed low-intensity ultrasound: a new salvage procedure for delayed unions and nonunions after leg lengthening in children J Pediatr Orthop 2005; 6 : 750-4. J Oral Maxillofac Surg Erdogan O 64 180 2006 Erdogan O, Esen E, U¨ stun Y, et al. Effects of low-intensity pulsed ultrasound on healing of mandibular fractures: an experimental study in rabbits J Oral Maxillofac Surg 2006; 64 : 180-8. Ultrasound Med Biol Mukai S 31 1713 2005 Mukai S, Ito H, Nakagawa Y, Akiyama H, Miyamoto M, Nakamura T. Transforming growth factor-b1 mediates the effects of low-intensity pulsed ultrasound in chondrocytes Ultrasound Med Biol 2005; 31 : 1713-21. FEBS Lett Chen YJ 554 154 2003 Chen YJ, Wang CJ, Yang KD, et al. Pertussis toxin-sensitive Gai protein and ERK dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts FEBS Lett 2003; 554 : 154-8. Biochem Biophys Res Commun Naruse K 268 216 2000 Naruse K, Mikuni-Takagaki Y, Azuma Y, et al. Anabolic response of mouse bone-marrow-derived stromal cell clone ST2 cells to lowintensity pulsed ultrasound Biochem Biophys Res Commun 2000; 268 : 216-0. Biochem Biophys Res Commun Warden SJ 286 443 2001 Warden SJ, Favaloro JM, Bennell KL, et al. Low-intensity pulsed ultrasound stimulates a bone forming response in UMR-106 cells Biochem Biophys Res Commun 2001; 286 : 443-50. J Bone Miner Res Naruse K 18 360 2003 Naruse K, Miyauchi A, Itoman M, Mikuni-Takagaki Y. Distinct anabolic response of osteoblasts to low-intensity pulsed ultrasound J Bone Miner Res 2003; 18 : 360-9. Biochem Biophys Res Commun Kokubu T 256 284 1999 Kokubu T, Matsui N, Fujioka H, Tsunoda M, Mizuno K. Low intensity pulsed ultrasound exposure increases prostaglandin E2 production via the induction of cyclooxygenase-2 mRNA in mouse osteoblasts Biochem Biophys Res Commun 1999; 256 : 284-7. Calcif Tissue Int Saito M 75 384 2004 Saito M, Fujii K, Tanaka T, Soshi S. Effect of low and high intensity pulsed ultrasound on collagen post-translational modifications in MC3T3-E1 osteoblasts Calcif Tissue Int 2004; 75 : 384-95. Mol Pharmacol Tang CH 69 2047 2006 Tang CH, Yang RS, Huang TH, et al. Ultrasound stimulates cyclooxygenase- 2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts Mol Pharmacol 2006; 69 : 2047-57. Cell Tissue Res Bosshardt DD 320 399 2005 Bosshardt DD, Degen T, Lsng NP. Sequence of protein expression of bone sialoprotein and osteopontin at the developing interface between repair cementum and dentin in human deciduous teeth Cell Tissue Res 2005; 320 : 399-407. Arch Oral Biol Matsuda N 43 987 1998 Matsuda N, Yokoyama K, Takeshita S, Watanabe M. Role of epidermal growth factor and its receptor in mechanical stressinduced differentiation of human periodontal ligament cells in vitro Arch Oral Biol 1998; 43 : 987-7. Ultrasound Med Biol Young SR 16 261 1990 Young SR, Dyson M. The effect of therapeutic ultrasound on angiogenesis Ultrasound Med Biol 1990; 16 : 261-9. J Periodontol Inubushi T 79 984 2008 Inubushi T, Tanaka E, Rego EB, et al. Effects of ultrasound on the proliferation and differentiation of cementoblast lineage cells J Periodontol 2008; 79 : 984-0. Arch Oral Biol Mostafa NZ 54 743 2009 Mostafa NZ, Uludag H, Dederich DN, Doschak MR, El-Bialy TH. Anabolic effects of low-intensity pulsed ultrasound on human gingival fibroblasts Arch Oral Biol 2009; 54 : 743-8. Ten Cate AR The periodontium: Oral histology, development, structure and function. Mosby: St Louis, MO 2003; pp. 276-9. Eur J Orthod Hollender L 2 197 1980 Hollender L, Ronneman A, Thilander B. Root resorption, marginal bone support and clinical crown length in orthodontically treated patients Eur J Orthod 1980; 2 : 197-205. Eur J Orthod Levander E 10 30 1988 Levander E, Malmgren O. Evaluation of the risk of root resorption during orthodontic treatment: a study of upper incisors Eur J Orthod 1988; 10 : 30-8. Am J Orthod Dentofacial Orthop Linge L 99 35 1991 Linge L, Linge BO. Patient characteristics and treatment variables associated with apical root resorption during orthodontic treatment Am J Orthod Dentofacial Orthop 1991; 99 : 35-43. A clinical experimental study. Eur J Orthod Levander E 16 223 1994 Levander E, Malmgren O, Eliasson S. Evaluation of root resorption in relation to two orthododntic treatment regimes A clinical experimental study Eur J Orthod 1994; 16 : 223-8. Am J Orthod Dentofacial Orthop Kurol J 110 303 1996 Kurol J, Owman-Moll P, Lundgren D. Time related root resorption after application of a controlled continuous orthodontic force Am J Orthod Dentofacial Orthop 1996; 110 : 303-10. Quint Int Rita FN 30 9 1999 Rita FN, David EW, James LG. Tooth resorption Quint Int 1999; 30 : 9-25. Arch Oral Biol Matias MA 48 709 2003 Matias MA, Li H, Young WG, Bartold PM. Immunohistochemical localization of extracellular matrix proteins in the periodontium during cementogenesis in the rat molar Arch Oral Biol 2003; 48 : 709-16. J Dent Res Bosshardt DD 84 390 2005 Bosshardt DD. Are cementoblasts a subpopulation of osteoblasts or a unique phenotype? J Dent Res 2005; 84 : 390-406. Crit Rev Oral Biol Med Pavlin D 12 414 2001 Pavlin D, Gluhak J. Effect of mechanical loading on periodontal cells Crit Rev Oral Biol Med 2001; 12 : 414-24. Am J Orthod Dentofacial Orthop El-Bialy T 126 186 2004 El-Bialy T, El-Shamy I, Graber TM. Repair of orthodontically induced root resorption by ultrasound in humans Am J Orthod Dentofacial Orthop 2004; 126 : 186-93. Ultrasound Med Biol Dalla-Bona DA 32 943 2006 Dalla-Bona DA, Tanaka E, Oka H, et al. Effects of ultrasound on cementoblast metabolism in vitro Ultrasound Med Biol 2006; 32 : 943-8. Arch Oral Biol Dalla-Bona DA 53 318 2008 Dalla-Bona DA, Tanaka E, Inubushi T, et al. Cementoblast response to low- and high-intensity ultrasound Arch Oral Biol 2008; 53 : 318-23. Ultrasound Med Biol Rego EB 36 907 2010 Rego EB, Inubushi T, Kawazoe A, et al. Ultrasound stimulation induces PGE2 synthesis promoting cementoblastic differentiation through EP2/EP4 receptor pathway Ultrasound Med Biol 2010; 36 : 907-15. J Periodont Res Rego EB 46 648 2011 Rego EB, Inubushi T, Miyauchi M, et al. Ultrasound stimulation attenuates root resorption on rat replanted molars and impairs TNF- a signaling in vitro J Periodont Res 2011; 46 : 648-54. J Periodont Res Ikai H 43 212 2008 Ikai H, Tamura T, Watanabe T, et al. Low-intensity pulsed ultrasound accelerates periodontal wound healing after flap surgery J Periodont Res 2008; 43 : 212-6. J Periodontol Shiraishi R 82 1498 2011 Shiraishi R, Masaki C, Toshinaga A, Hosokawa R, et al. The effects of low-intensity pulsed ultrasound exposure on gingival Cells J Periodontol 2011; 82 : 1498-503. Brånemark PI, Zarb G, Albreksson T. Tissue-integrated prosthesis In: BrÃ¥nemark PI, Ed. Osseointegration in clinical dentistry. Chicago, Il: Quintessence Publishing Co 1985; pp. 11-76. J Biomed Mater Res Buser D 25 889 1991 Buser D, Schenk RK, Steinmann S, Fiorellini JP, Fox CH, Stich H. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs J Biomed Mater Res 1991; 25 : 889-902. Clin Oral Implant Res Ericsson I 5 202 1994 Ericsson I, Johansson CB, Bystedt H, Norton MR. A histomorphometric evaluation of bone-to-implant contact on machineprepared and roughened titanium dental implants: a pilot study in the dog Clin Oral Implant Res 1994; 5 : 202-6. Clin Oral Implant Res Klokkevold PR 12 350 2001 Klokkevold PR, Johnson P, Dadgostari S, Caputo A, Davies JE, Nishimura RD. Early endosseous integration enhanced by dual acid etching of titanium: a torque removal study in the rabbit Clin Oral Implant Res 2001; 12 : 350-7. J Dent Res Nakamura H 86 515 2005 Nakamura H, Saruwatari L, Aita H, Takeuchi K, Ogawa T. Molecular and biomechanical characterization of mineralized tissue by dental pulp cells on titanium J Dent Res 2005; 86 : 515-20. Bone Liu Y 36 745 2005 Liu Y, DE Groot K, Hunkizer EB. BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model Bone 2005; 36 : 745-57. Biomaterials Fini M 27 681 2004 Fini M, Giavaresi G, Setti S, Martini L, Torricelli P, Giardino R. Current trends in the enhancement of biomaterial osteointegration Biophysical stimulation Biomaterials 2004; 27 : 681-90. J Orthop Res Tanzer M 14 901 1996 Tanzer M, Harvey E, Kay A, Morton P, Bobyn JD. Effect of noninvasive low intensity ultrasound on bone growth into porouscoated implants J Orthop Res 1996; 14 : 901-6. Ultrasound Med Biol Hsu SK 37 403 2011 Hsu SK, Huang WT, Liu BS, Li SM, Chen HT, Chang CJ. Effects of near-field ultrasound stimulation on new bone formation and osseointegration of dental titanium implants in vitro and in vivo Ultrasound Med Biol 2011; 37 : 403-16. Eur J Dent Ustun Y 2 254 2008 Ustun Y, Erdogan O, Kurkcu M, Akova T, Damlar I. Effects of low-intensity pulsed ultrasound on dental implant osseointegration a preliminary report Eur J Dent 2008; 2 : 254-62. Arch Oral Biol Scheven BA 54 185 2009 Scheven BA, Man J, Millard JL, et al. VEGF and odontoblast-like cells: stimulation by low frequency ultrasound Arch Oral Biol 2009; 54 : 185-91. Hum Gene Ther Nakashima M 14 591 2003 Nakashima M, Tachibana K, Iohara K, Ito M, Ishikawa M, Akamine A. Induction of reparative dentin formation by ultrasoundmediated gene delivery of growth/differentiation factor 11 Hum Gene Ther 2003; 14 : 591-7. Am J Orthod Dentofacial Orthop El-Bialy TH 124 427 2003 El-Bialy TH, el-MoneimZaki A, Evans CA. Effect of ultrasound on rabbit mandibular incisor formation and eruption after mandibular osteodistraction Am J Orthod Dentofacial Orthop 2003; 124 : 427-34. Dent Clin North Am Ramseier CA 50 245 2006 Ramseier CA, Abramson ZR, Jin Q, Giannobile WV. Gene therapeutics for periodontal regenerative medicine Dent Clin North Am 2006; 50 : 245-63. Indian J Dent Res Pradeep AR 14 224 2003 Pradeep AR, Karthikeyan BV. Tissue engineering: prospect for regenerating periodontal tissues Indian J Dent Res 2003; 14 : 224-9. Spine Nishida K 31 1415 2006 Nishida K, Doita M, Takada T, et al. Sustained transgene expression in intervertebral disc cells in vivo mediated by microbubbleenhanced ultrasound gene therapy Spine 2006; 31 : 1415-9. Eur J Echocardiogr Dijkmans PA 5 245 2004 Dijkmans PA, Juffermans LJ, Musters RJ, et al. Microbubbles and ultrasound: from diagnosis to therapy Eur J Echocardiogr 2004; 5 : 245-56. J Am Coll Cardiol Bekeredjian R 45 329 2005 Bekeredjian R, Grayburn PA, Shohet RV. Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine J Am Coll Cardiol 2005; 45 : 329-5. Gene Ther Shimamura M 11 1532 2004 Shimamura M, Sato N, Taniyama Y, et al. Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound Gene Ther 2004; 11 : 1532-9. Ultrasound Med Biol Aoi A 34 425 2008 Aoi A, Watanabe Y, Mori S, Takahashi M, Vassaux G, Kodama T. Herpes simplex virus thymidine kinase-mediated suicide gene therapy using nano/microbubbles and ultrasound Ultrasound Med Biol 2008; 34 : 425-34. Gene Ther Sheyn D 15 257 2008 Sheyn D, Kimelman-Bleich N, Pelled G, Zilberman Y, Gazit D, Gazit Z. Ultrasound-based nonviral gene delivery induces bone formation in vivo Gene Ther 2008; 15 : 257-66. J Dent Res Chen R 88 1008 2009 Chen R, Chiba M, Mori S, Fukumoto M, Kodama T. Periodontal gene transfer by ultrasound and nano/microbubbles J Dent Res 2009; 88 : 1008-3. J Gene Med Osawa K 11 633 2009 Osawa K, Okubo Y, Nakao K, Koyama N, Bessho K. Osteoinduction by microbubble-enhanced transcutaneous sonoporation of human bone morphogenetic protein-2 J Gene Med 2009; 11 : 633-41. Ups J Med Sci Watanuki M 114 242 2009 Watanuki M, Kishimoto KN, Kotajima S, Iwabuchi S, Kokubun S. Effect of low-intensity pulsed ultrasound on scaffold-free ectopic bone formation in skeletal muscle Ups J Med Sci 2009; 114 : 242-8. Oral Surg Oral Med Oral Pathol Oral Radiol Endod Gunraj MN 88 647 1999 Gunraj MN. Dental root resorption Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 88 : 647-53. J Appl Oral Sci Ravindran S 17 481 2009 Ravindran S, Chaudhary M, Tumsare M, Patil S, Wadhwan V. A Scanning electron microscopic study of the patterns of external root resorption under different conditions J Appl Oral Sci 2009; 17 : 481-6. Angle Ortho Loberg EL 64 395 1994 Loberg EL, Engstrom H. Thyroid administration to reduce root resorption Angle Ortho 1994; 64 : 395-9. J Dent Res Igarashi K 75 1644 1996 Igarashi K, Adachi H, Mitani H, Shinoda H. Inhibitory effect of the topical administration of a bisphosphonate (risedronate) on root resorption incident to orthodontic tooth movement in rats J Dent Res 1996; 75 : 1644-9. Am J Orthod Dentofacial Orthop Talic NF 129 252 2006 Talic NF, Evans C, Zaki AM. Inhibition of orthodontically induced root resorption with echistatin, an RGD-containing peptide Am J Orthod Dentofacial Orthop 2006; 129 : 252-60. J Periodont Res Fujishiro N 43 143 2008 Fujishiro N, Anan H, Hamachi T, Maeda K. The role of macrophages in the periodontal regeneration using Emdogain® gel J Periodont Res 2008; 43 : 143-55. J Indian Soc Periodontol Bains VK 12 55 2008 Bains VK, Mohan R, Bains R. Application of ultrasound in periodontics: Part II J Indian Soc Periodontol 2008; 12 : 55-61.