Dental Tissue Repair: Novel Models for Tissue Regeneration Strategies

TODENTJ-25-03-2019_TODENTJ-6-214 1553505415 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 12 28 2012 6 1 Dental Tissue Repair: Novel Models for Tissue Regeneration Strategies Alastair J Sloan Christopher D Lynch Studies have shown that dentin matrices contain reservoirs of bioactive molecules capable of directing tissue repair. Elucidating the release mechanisms of such endogenous growth factors will enhance our understanding of dentinpulp regeneration and support the development of novel treatment modalities to enhance dentin repair following trauma and disease. Current clinical practice using new materials which are perceived to maintain pulpal viability require biological evidence to assess their therapeutic benefit and there is a need for better effective methods of assessing therapeutic approaches to improving dentin regeneration at the cellular and tissue level. Experimental modelling of dentin regeneration is hampered by the lack of suitable models. In vivo and in vitro studies have yielded considerable information on the processes taking place, but are limited, due to the cost, ethics and lack of cell/matrix interactions. Novel organotypic models, whereby cells and tissues are cultured in situ may provide a more suitable model system to facilitate dental tissue engineering and regeneration. 12 28 2012 214 219 TODENTJ-6-214 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2012-7-5 2012-8-10 2012-9-27 2012-12-28 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601206010214 1553505415 https://opendentistryjournal.com/VOLUME/6/PAGE/214/ https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-214/TODENTJ-6-214.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-214/TODENTJ-6-214.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-214/TODENTJ-6-214.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-214/TODENTJ-6-214.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-214/TODENTJ-6-214.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-214/TODENTJ-6-214.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-214/TODENTJ-6-214.pdf https://opendentistryjournal.com/contents/volumes/V6/TODENTJ-6-214/TODENTJ-6-214.xml Am Rheum Dis Graichen H 64 1120 2005 Graichen H, Al-Shamari D, Hinterwimmer S, von Eisenhart-Rothe R, Vogl T, Eckstein F. 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