TODENTJ-25-03-2019_TODENTJ-5-96 1553505256 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 7 7 2011 5 1 Amir Reza Rokn Mohammad Amin Khodadoostan Amir Ali Reza Rasouli Ghahroudi Puria Motahhary Mohammad Javad Kharrazi Fard Hugo De Bruyn Rose Afzalifar Ehsan Soolar Ahmad Soolari Background: Although autogenous bone grafts are considered the gold standard for bone regeneration, they have certain limitations, including patient morbidity at the harvest site. Synthetic bone substitutes have been developed to overcome some of these limitations. The present study aimed to compare the osteogenic properties of Straumann Bone Ceramic (SBC), which is a biphasic calcium phosphate, with Bio-Oss, an inorganic bovine bone material, in an animal model. Methods: Thirteen rabbits were included in this study. In each rabbit, four 6.5-mm-diameter identical defects were prepared on the calvarium. One site was filled with Bio-Oss, the second site was treated with small-particle SBC, the third site was treated with large-particle SBC, and the fourth site was left as an untreated control. After 4 and 8 weeks, the animals were sacrificed, and histologic and histomorphometric examinations were performed. The data were analyzed using Friedman and multiple-comparison Mann-Whitney U tests. Results: There were no statistically significant differences in the amount of bone fill between the four groups. L-SBC showed more inflammation and foreign-body reactions than the other bone substitutes. Conclusion: No statistically significant differences were found between groups. Further studies on this issue seem necessary. 7 7 2011 96 104 TODENTJ-5-96 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2010-10-4 2011-2-16 2011-4-5 2011-7-7 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601105010096 1553505256 https://opendentistryjournal.com/VOLUME/5/PAGE/96/ https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-96/TODENTJ-5-96.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-96/TODENTJ-5-96.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-96/TODENTJ-5-96.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-96/TODENTJ-5-96.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-96/TODENTJ-5-96.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-96/TODENTJ-5-96.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-96/TODENTJ-5-96.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-96/TODENTJ-5-96.xml Folia Morphol (Warsz) Kauschke E 65 37 2006 Kauschke E, Rumpel E, Fanghanel J, Bayerlein T, Gedrange T, Proff P. The in vitro viability and growth of fibroblasts cultured in the presence of different bone grafting materials (nanobone and straumann bone Ceramic) Folia Morphol (Warsz) 2006; 65 : 37-42. Clin Orthop Res Bucholz RW 395 44 2002 Bucholz RW. Nonallograft osteoconductive bone graft substitute Clin Orthop Res 2002; 395 : 44-52. Carol Stream, IL: Quintessence Lynch SE 1999 Lynch SE, Genco RJ, Marx RE. Tissue engineering: applications in maxillofacial surgery and periodontics Carol Stream, IL: Quintessence 1999. J Orthop Res Habibovic P 26 1363 2008 Habibovic P, Kruyt MC, Juhl MV, et al. Comparative in vivo study of six hydroxyapatite-based bone graft substitutes J Orthop Res 2008; 26 : 1363-70. Biomaterials Fellah BH 29 1177 2008 Fellah BH, Gauthier O, Weiss P, Chappard D, Layrolle P. Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model Biomaterials 2008; 29 : 1177-88. J Periodontol Stein JM 80 1774 2009 Stein JM, Fickl S, Yekta SS, Hoischen U, Ocklenburg C, Smeets R. Clinical evaluation of a biphasic calcium composite grafting material in the treatment of human periodontal intrabony defects: a 12-month randomized controlled clinical trial J Periodontol 2009; 80 : 1774-82. Am J Sports Med Crawford MJ 32 580 2004 Crawford MJ, Swenson CL, Arnoczky SP, O'Shea J, Ross H. Lyophilization does not inactivate infectious retrovirus in systemically infected bone and tendon allografts Am J Sports Med 2004; 32 (3) : 580-6. Acta Orthop Scand Munting E 59 34 1988 Munting E, Wilmart JF, Wijne A, Hennebert P, Delloye C. Effect of sterilization on osteoinduction. Comparison of five methods in demineralized rat bone Acta Orthop Scand 1988; 59 : 34-8. J Periodontol Anderegg CR 70 384 1999 Anderegg CR, Alexander DC, Freidman M. A bioactive glass particulate in the treatment of molar furcation invasions J Periodontol 1999; 70 : 384-7. Clin Oral Implants Res Hammerle CH 9 151 1998 Hammerle CH, Chiantella GC, Karring T, Lang NP. The effect of a deproteinized bovine bone mineral on bone regeneration around titanium dental implants Clin Oral Implants Res 1998; 9 : 151-62. J Biomed Mater Res B Appl Biomater Nomura T 73 29 2005 Nomura T, Katz JL, Powers MP, Saito C. Evaluation of the micromechanical elastic properties of potential bone-grafting materials J Biomed Mater Res B Appl Biomater 2005; 73 : 29-34. Oral Dis Orsini G 13 586 2007 Orsini G, Scarano A, Degidi M, Caputi S, Iezzi G, Piattelli A. Histological and ultrastructural evaluation of bone around Bio-Oss particles in sinus augmentation Oral Dis 2007; 13 : 586-93. Clin Oral Implants Res Simion M 18 620 2007 Simion M, Fontana F, Rasperini G, Maiorana C. Vertical ridge augmentation by expanded-polytetrafluoroethylene membrane and a combination of intraoral autogenous bone graft and deproteinized anorganic bovine bone (Bio Oss) Clin Oral Implants Res 2007; 18 : 620-9. Trends Biomater Artif Organs Victoria EC 16 12 2002 Victoria EC, Gnanam FD. Synthesis and characterization of biphasic calcium phosphate Trends Biomater Artif Organs 2002; 16 (1) : 12-4. Implant Dent Paknejad M 17 471 2008 Paknejad M, Emtiaz S, Rokn A, Islamy B, Safiri A. Histologic and histomorphometric evaluation of two bone substitute materials for bone regeneration: an experimental study in sheep Implant Dent 2008; 17 : 471-9. J Mater Sci Mater Med Farina NM 19 1565 2008 Farina NM, Guzon FM, Pena ML, Cantalapiedra AG. In vivo behaviour of two different biphasic ceramic implanted in mandibular bone of dogs J Mater Sci Mater Med 2008; 19 : 1565-73. Oral Surg Oral Med Oral Pathol Oral Radiol Endod Jafarian M 105 e14 2008 Jafarian M, Eslaminejad MB, Khojasteh A, et al. Marrow-derived mesenchymal stem cells-directed bone regeneration in the dog mandible: a comparison between biphasic calcium phosphate and natural bone mineral Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 105 : e14-24. J Biomed Mater Res A Bodde EW 82 711 2007 Bodde EW, Wolke JG, Kowalski RS, Jansen JA. Bone regeneration of porous beta-tricalcium phosphate (Conduit TCP) and of biphasic calcium phosphate ceramic (Biosel) in trabecular defects in sheep J Biomed Mater Res A 2007; 82 : 711-22. Int J Oral Maxillofac Surg Schwarz F 36 1198 2007 Schwarz F, Herten M, Ferrari D, et al. Guided bone regeneration at dehiscence-type defects using biphasic hydroxyapatite + beta tricalcium phosphate (Bone Ceramic) or a collagen-coated natural bone mineral (Bio-Oss Collagen): an immunohistochemical study in dogs Int J Oral Maxillofac Surg 2007; 36 : 1198-206. J Periodontol Artzi Z 71 1015 2000 Artzi Z, Tal H, Dayan D. Porous bovine bone mineral in healing of human extraction sockets. Part 1: histomorphometric evaluations at 9 months J Periodontol 2000; 71 : 1015-23. Clin Oral Implants Res Fuerst G 15 733 2004 Fuerst G, Tangl S, Gruber R, Gahleitner A, Sanroman F, Watzek G. Bone formation following sinus grafting with autogenous bone-derived cells and bovine bone mineral in minipigs: preliminary findings Clin Oral Implants Res 2004; 15 : 733-40. J Periodontol Iezzi G 79 192 2008 Iezzi G, Scarano A, Mangano C, Cirotti B, Piattelli A. Histologic results from a human implant retrieved due to fracture 5 years after insertion in a sinus augmented with anorganic bovine bone J Periodontol 2008; 79 : 192-8. Clin Oral Implants Res Merkx MA 11 422 2000 Merkx MA, Maltha JC, Freihofer HP. Incorporation of composite bone implants in the facial skeleton Clin Oral Implants Res 2000; 11 : 422-9. Int J Oral Maxillofac Implants Piattelli M 4 835 1999 Piattelli M, Favero GA, Scarano A, Orsini G, Piattelli A. Bone reactions to anorganic bovine bone (Bio-Oss) used in sinus augmentation procedures: a histologic long-term report of 20 cases in humans Int J Oral Maxillofac Implants 1999; 4 : 835-40. J Periodontol Scarano A 75 1161 2004 Scarano A, Pecora G, Piattelli M, Piattelli A. Osseointegration in a sinus augmented with bovine porous bone mineral: histological results in an implant retrieved 4 years after insertion: a case report J Periodontol 2004; 75 : 1161-6. J Biomed Mater Res A Develioglu H 80 505 2007 Develioglu H, Saraydin SU, Dupoirieux L, Sahin ZD. Histological findings of long-term healing of the experimental defects by application of a synthetic biphasic ceramic in rats J Biomed Mater Res A 2007; 80 : 505-8. J Mater Sci Mater Med Lu J 15 361 2004 Lu J, Blary MC, Vavasseur S, Descamps M, Anselme K, Hardouin P. Relationship between bioceramics sintering and micro-particles-induced cellular damages J Mater Sci Mater Med 2004; 15 : 361-5. Clin Oral Investig Sculean A 8 70 2004 Sculean A, Stavropoulos A, Windisch P, Keglevich T, Karring T, Gera I. Healing of human intrabony defects following regenerative periodontal therapy with a bovine-derived xenograft and guided tissue regeneration Clin Oral Investig 2004; 8 : 70-4. Clin Oral Implants Res Slotte C 10 468 1999 Slotte C, Lundgren D. Augmentation of calvarial tissue using non-permeable silicone domes and bovine bone mineral: an experimental study in the rat Clin Oral Implants Res 1999; 10 : 468-76. J Clin Periodontol Stavropoulos A 30 636 2003 Stavropoulos A, Kostopoulos L, Nyengaard JR, Karring T. Deproteinized bovine bone (Bio-Oss) and bioactive glass (Biogran) arrest bone formation when used as an adjunct to guided tissue regeneration (GTR): an experimental study in the rat J Clin Periodontol 2003; 30 : 636-43. J Periodontol Stephan EB 70 364 1999 Stephan EB, Jiang D, Lynch S, Bush P, Dziak R. Anorganic bovine bone supports osteoblastic cell attachment and proliferation J Periodontol 1999; 70 : 364-9. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi Lu J 23 85 2006 Lu J, Tang T, Ding H, Dai K. [Micro-particles of bioceramics could cause cell and tissue damage] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2006; 23 : 85-9. J Periodontol Crespi R 80 210 2009 Crespi R, Cappare P, Gherlone E. Magnesium-enriched hydroxyapatite compared to calcium sulfate in the healing of human extraction sockets: radiographic and histomorphometric evaluation at 3 months J Periodontol 2009; 80 : 210-18. J Nucl Med Francis MD 21 1185 1980 Francis MD, Ferguson DL, Tofe AJ, Bevan JA, Michaels SE. Comparative evaluation of three diphosphonates: in vitro adsorption (C- 14 labeled) and in vivo osteogenic uptake (Tc-99m complexed) J Nucl Med 1980; 21 : 1185-9. Folia Morphol (Warsz) Dietze S 65 63 2006 Dietze S, Bayerlein T, Proff P, Hoffmann A, Gedrange T. The ultrastructure and processing properties of straumann bone ceramic and nanobone Folia Morphol (Warsz) 2006; 65 : 63-5. J Clin Periodontol Richardson CR 26 421 1999 Richardson CR, Mellonig JT, Brunsvold MA, McDonnell HT, Cochran DL. Clinical evaluation of Bio-Oss: a bovine-derived xenograft for the treatment of periodontal osseous defects in humans J Clin Periodontol 1999; 26 : 421-8. J Mater Sci Mater Med Sena LA 20 2394 2009 Sena LA, Caraballo MM, Rossi AM, Soares GA. Synthesis and characterization of biocomposites with different hydroxyapatite-collagen ratios J Mater Sci Mater Med 2009; 20 (12) : 2394-400. Artif Cells Blood Substit Immobil Biotechnol Oktar FN 27 367 1999 Oktar FN, Kesenci K, Piskin E. Characterization of processed tooth hydroxyapatite for potential biomedical implant applications Artif Cells Blood Substit Immobil Biotechnol 1999; 27 : 367-79. Dent Mater J Irokawa D 2010 Irokawa D, Ota M, Yamamoto S, Shibukawa Y, Yamada S. Effect of ß tricalcium phosphate particle size on recombinant human platelet-derived growth factor-BB-induced regeneration of periodontal tissue in dog Dent Mater J 2010. [Epub ahead of print] Clin Oral Implants Res Chackartchi T 22 473 2011 Chackartchi T, Iezzi G, Goldstein M, et al. Sinus floor augmentation using large (1-2 mm) or small (0.25-1 mm) bovine bone mineral particles: a prospective, intra-individual controlled clinical, micro-computerized tomography and histomorphometric study Clin Oral Implants Res 2011; 22 : 473-80. Clin Oral Implants Res Park JW 20 372 2009 Park JW, Jang JH, Bae SR, An CH, Suh JY. Bone formation with various bone graft substitutes in critical-sized rat calvarial de-fect Clin Oral Implants Res 2009; 20 (4) : 372-8. Clin Oral Implants Res Schwartz Z 19 1233 2008 Schwartz Z, Doukarsky-Marx T, Nasatzky E, et al. Differential effects of bone graft substitutes on regeneration of bone marrow Clin Oral Implants Res 2008; 19 (12) : 1233-45. Clin Implant Dent Relat Res Santos FA 12 18 2010 Santos FA, Pochapski MT, Martins MC, Zenóbio EG, Spolidoro LC, Marcantonio E Jr. Comparison of biomaterial implants in the dental socket: histological analysis in dogs Clin Implant Dent Relat Res 2010; 12 (1) : 18-25. Bone Newman E 16 277S 1995 Newman E, Turner AS, Wark JD. The potential of sheep for the study of osteopenia: current status and comparison with other animal models Bone 1995; 16 : 277S-84S. Skeletal Radiol Castaneda S 35 34 2006 Castaneda S, Largo R, Calvo E, et al. Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits Skeletal Radiol 2006; 35 : 34-41. Biomaterials Xu S 29 2588 2008 Xu S, Lin K, Wang Z, et al. Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics Biomaterials 2008; 29 : 2588-96. J Craniomaxillofac Surg Cavalcanti SC 36 354 2008 Cavalcanti SC, Pereira CL, Mazzonetto R, de Moraes M, Moreira RW. Histological and histomorphometric analyses of calcium phosphate cement in rabbit calvaria J Craniomaxillofac Surg 2008; 36 : 354-9. J Craniomaxillofac Surg Lundgren D 20 257 1992 Lundgren D, Nyman S, Mathisen T, Isaksson S, Klinge B. Guided bone regeneration of cranial defects, using biodegradable barriers: an experimental pilot study in the rabbit J Craniomaxillofac Surg 1992; 20 : 257-60. Clin Implant Dent Relat Res Torres J 10 106 2008 Torres J, Tamimi FM, Tresguerres IF, et al. Effect of solely applied platelet- rich plasma on osseous regeneration compared to Bio-Oss: a morphometric and densitometric study on rabbit calvaria Clin Implant Dent Relat Res 2008; 10 : 106-2. J Periodontal Implant Sci Sohn JY 40 180 2010 Sohn JY, Park JC, Um YJ, et al. Spontaneous healing capacity of rabbit cranial defects of various sizes J Periodontal Implant Sci 2010; 40 : 180-7. Int J Periodontics Restorative Dent Froum SF 28 273 2008 Froum SF, Wallace SS, Ech SC, Elian N, Tarnow DP. Histomorphometric comparison of a biphasic bone ceramic to anorganic bovine bone for sinus augmentation: 6- to 8-month postsurgical assessment of vital bone formation. A pilot study Int J Periodontics Restorative Dent 2008; 28 : 273-81. J Oral Sci Cruz AC 48 219 2006 Cruz AC, Pochapski MT, Daher JB, Silva JC, Pilatti GL, Santos FA. Physicochemical characterization and biocompatibility evaluation of hydroxyapatites J Oral Sci 2006; 48 : 219-6. Scand J Dent Res Pinholt EM 99 154 1991 Pinholt EM, Bang G, Hannaes HR. Alveolar ridge augmentation in rats by Bio-Oss Scand J Dent Res 1991; 99 : 154-61. J Clin Periodontol Cardaropoli G 32 435 2005 Cardaropoli G, Araújo M, Hayacibara R, Sukekava F, Lindhe J. Healing of extraction sockets and surgically produced:augmented and non-augmented defects in the alveolar ridge: an experimental study in the dog J Clin Periodontol 2005; 32 : 435-0. J Oral Maxillofac Surg Indovina A Jr 60 53 2002 Indovina A Jr, Block MS. Comparison of 3 bone substitutes in canine extraction sites J Oral Maxillofac Surg 2002; 60 : 53-8. Clin Oral Implants Res Frenken JWFH 21 201 2010 Frenken JWFH, Bouwman WF, Bravenboer N, Zijderveld SA, Schulten EAJM, Ten Bruggenkate CM. The use of Straumann Bone Ceramic in a maxillary sinus floor elevation procedure: a clinical, radiological, histological and histomorphometric evaluation with a 6-month healing period Clin Oral Implants Res 2010; 21 (2) : 201-8.