TODENTJ-25-03-2019_TODENTJ-5-84 1553505251 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 5 18 2011 5 1 J Eggerath T Kremniczky P Gaengler W.H Arnold Aim of this in-vitro-study was to assess the remineralization potential of a tooth cleaning tablet with different fluoride content quantitatively using EDX analysis. Twenty three caries free impacted third molars were examined; enamel surfaces were wax coated leaving two 3x4mm windows for exposure to demineralization/remineralization cycles. The teeth were randomly assigned to 4 groups of 5 control and 6 experimental teeth each. Demineralization by standardized HEC-gel, pH 4.7 at 37°C for 72h, was alternated by rinsing in remineralization solution, pH 7.0 at 37°C for 72h, total challenge time 432h. The negative control group N was treated during remineralization cycles with saline; positive control group P was treated with remineralization solution; experimental group D1 was exposed to remineralization solution containing Denttabs®-tablets with 1450 ppm F; experimental group D2 was exposed to remineralization solution and Denttabs®-tablets with 4350 ppm F. Each tooth was cut into serial sections and analyzed by scanning electron microscopy with EDX element analysis for assessment of the different zones of the lesions in 3 representative sections. Statistical analysis was based on the AVOVA test for repeated measurements and post hoc Bonferroni adjustment. The results showed a significantly higher Ca and P content in the body of the lesion in both fluoride treated groups compared to the controls. It can be concluded that higher concentrations of NaF may be more effective in remineralization of early advanced caries lesions. 5 18 2011 84 89 TODENTJ-5-84 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2011-1-11 2011-2-8 2011-3-8 2011-5-18 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601105010084 1553505251 https://opendentistryjournal.com/VOLUME/5/PAGE/84/ https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-84/TODENTJ-5-84.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-84/TODENTJ-5-84.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-84/TODENTJ-5-84.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-84/TODENTJ-5-84.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-84/TODENTJ-5-84.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-84/TODENTJ-5-84.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-84/TODENTJ-5-84.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-84/TODENTJ-5-84.xml BMC Oral Health Arnold WH 6 8 2006 Arnold WH, Dorow A, Langenhorst S, Gintner Z, Banoczy J, Gaengler P. Effect of fluoride toothpastes on enamel demineralization BMC Oral Health 2006; 6 : 8. J Dent Res Ten Cate JM 87 943 2008 Ten Cate JM, Buijs MJ, Miller CC, Exterkate RA. Elevated fluoride products enhance remineralization of advanced enamel lesions J Dent Res 2008; 87 : 943-7. Caries Res ten Cate JM 40 136 2006 ten Cate JM, Exterkate RA, Buijs MJ. The relative efficacy of fluoride toothpastes assessed with pH cycling Caries Res 2006; 40 : 136-41. Cent Eur J Medicine Naumova EA 5 375 2010 Naumova EA, Arnold WH, Gaengler P. Fluoride bioavailability in saliva using DENTTABS®compared to dentifrice Cent Eur J Medicine 2010; 5 : 375-80. Open Dent J Naumova EA 4 185 2010 Naumova EA, Gängler P, Zimmer S, Arnold WH. Influence of individual saliva secretion on fluoride bioavailability Open Dent J 2010; 4 : 185-90. Arch Oral Biol Naumova EA 2010 Naumova EA, Kuehnl P, Hertenstein P, et al. Individual fluoride bioavailability in saliva and plaque Arch Oral Biol 2010. submitted BMC Oral Health Gängler P 9 25 2009 Gängler P, Kremniczky T, Arnold WH. In vitro effect of fluoride oral hygiene tablets on artificial caries lesion formation and remineralization in human enamel BMC Oral Health 2009; 9 : 25. Dent Mater Featherstone JD 12 194 1996 Featherstone JD. Modeling the caries-inhibitory effects of dental materials Dent Mater 1996; 12 : 194-7. Acta Odontol Scand ten Cate JM 57 325 1999 ten Cate JM. Current concepts on the theories of the mechanism of action of fluoride Acta Odontol Scand 1999; 57 : 325-9. Caries Res Lynch RJ 40 522 2006 Lynch RJ, Mony U, Ten Cate JM. The effect of fluoride at plaque fluid concentrations on enamel de- and remineralisation at low pH Caries Res 2006; 40 : 522-9. J Dent Res Vogel GL 87 466 2008 Vogel GL, Schumacher GE, Chow LC, Takagi S, Carey CM. Ca pre-rinse greatly increases plaque and plaque fluid F J Dent Res 2008; 87 : 466-9. Arch Oral Biol Yamazaki H 52 110 2007 Yamazaki H, Litman A, Margolis HC. Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions Arch Oral Biol 2007; 52 : 110-20. Arch Oral Biol Arnold WH 52 591 2007 Arnold WH, Bietau V, Renner PO, Gaengler P. Micromorphological and micronanalytical characterization of stagnating and progressing root caries lesions Arch Oral Biol 2007; 52 : 591-7. Arch Oral Biol Arnold WH 48 467 2003 Arnold WH, Cerman M, Neuhaus K, Gaengler P. Volumetric assessment and quantitative element analysis of the effect of fluoridated milk on enamel demineralization Arch Oral Biol 2003; 48 : 467-73. Ann Anat Arnold WH 185 419 2003 Arnold WH, Konopka S, Kriwalsky MS, Gaengler P. Morphological analysis and chemical content of natural dentin carious lesion zones Ann Anat 2003; 185 : 419-24. Scand J Dent Res Gängler P 101 345 1993 Gängler P, Noren JG, Hoyer I, et al. Reactivity of young and old human enamel to demineralization Scand J Dent Res 1993; 101 : 345-9. Caries Res Heijnsbroek M 40 444 2006 Heijnsbroek M, Gerardu VA, Buijs MJ, et al. Increased salivary fluoride concentrations after post-brush fluoride rinsing not reflected in dental plaque Caries Res 2006; 40 : 444-8. Caries Res Ogaard B 35 40 2001 Ogaard B. CaF(2) formation: cariostatic properties and factors of enhancing the effect Caries Res 2001; 35 (Suppl 1) : 40-. Eur J Oral Sci ten Cate JM 105 461 1997 ten Cate JM. Review on fluoride, with special emphasis on calcium fluoride mechanisms in caries prevention Eur J Oral Sci 1997; 105 : 461-5. Caries Res Vogel GL 44 108 2010 Vogel GL, Tenuta LM, Schumacher GE, Chow LC. No calcium-fluoride-like deposits detected in plaque shortly after a sodium fluoride mouthrinse Caries Res 2010; 44 : 108-15.