TODENTJ-25-03-2019_TODENTJ-5-18 1553505230 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 3 2 2011 5 1 Sias R Grobler Abdul Majeed Mohamad H Moola Roelof J Rossouw Theuns van Wyk Kotze To clinically evaluate the effectiveness of Nite White 10% carbamide peroxide with amorphous calcium phosphate, potassium nitrate and fluoride over a 6-month follow-up period. Nite White was applied nightly for 14 days, according to the manufacturer’s instructions. The color of teeth 11 and 21 of twenty one subjects was measured with a spectrophotometer (L*; a*; b*). Subjects were instructed to take note of any tooth sensitivity and gingival irritation. For all three components (L*, a* and b*) statistical significant differences (p<0.05) in the values between base-line (pre-bleaching) and; after treatment, after 1-month, after 3-months as well as after 6-months were found (Wilcoxon Signed Rank Sum Test). Significant differences were also found amongst the ΔE*ab (0-14days) values and; ΔE*ab (0-1 month), ΔE*ab (0-3 months) and ΔE*ab (0-6 months). However, no significant differences were found between pairs of ΔE*ab (0-1 month), ΔE*ab (0-3 months) and ΔE*ab (0-6months). The decrease in ΔE*ab was the highest after 1 month (~30%). The highest decrease in L* was about 58% after 1 month. Over the 14-day treatment period tooth sensitivity was 24.5%. Conclusions: Nite White ACP demonstrated significant tooth-whitening (unit increase = 5.29) with a low tooth sensitivity (25%) probably due to the presence of amorphous calcium phosphate, potassium nitrate, and fluoride. The whitening effect decreased the most after one month and then maintained well even after a 6 month period (units 3.89). Clinical implications The product is a good tooth whitener with a color increase of about 5 units accompanied with a low sensitivity. 3 2 2011 18 23 TODENTJ-5-18 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2010-5-7 2010-8-11 2010-2-9 2011-3-2 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601105010018 1553505230 https://opendentistryjournal.com/VOLUME/5/PAGE/18/ https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-18/TODENTJ-5-18.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-18/TODENTJ-5-18.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-18/TODENTJ-5-18.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-18/TODENTJ-5-18.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-18/TODENTJ-5-18.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-18/TODENTJ-5-18.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-18/TODENTJ-5-18.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-18/TODENTJ-5-18.xml Dent Clin N Am Kihn PW 51 319 2007 Kihn PW. Vital tooth whitening Dent Clin N Am 2007; 51 : 319-. J Dent Meireles SS 36 878 2008 Meireles SS, Heckmann SS, Santos IS, Della Bona A, Demarco FF. A double blind randomized clinical trial of at-home tooth bleaching using two carbamide peroxide concentrations: 6-month follow-up J Dent 2008; 36 (11) : 878-4. J Can Dent Assoc dos Santos Medeiros MC 74 163 2008 dos Santos Medeiros MC, de Lima KC. Effectiveness of nightguard vital bleaching with 10% carbamide peroxide: a clinical study J Can Dent Assoc 2008; 74 (2) : 163-163e. Dent Mater J Goo DH 23 522 2004 Goo DH, Kwon TY, Nam SH, Kim HJ, Kim KH, Kim YJ. The efficiency of 10% carbamide peroxide gel on dental enamel Dent Mater J 2004; 23 (4) : 522-7. J Esthet Restor Dent Ritter AV 14 275 2002 Ritter AV, Leonard RH Jr, St Georges AJ, Caplan DJ, Haywood VB. Safety and stability of nightguard vital bleaching: 9 to 12 years post-treatment J Esthet Restor Dent 2002; 14 (5) : 275-85. Oper Dent Matis BA 32 549 2007 Matis BA, Cochran MA, Eckert GJ, Matis JI. In vivo study of two carbamide peroxide gels with different desensitizing agents Oper Dent 2007; 32 (6) : 549-5. J Dent Chen HP 36 718 2008 Chen HP, Chang CH, Liu JK, Chuang SF, Yang JY. Effect of fluoride containing bleaching agents on enamel surface properties J Dent 2008; 36 (9) : 718-25. J Prosthodont Lima DA 18 249 2009 Lima DA, Aguiar FH, Liporoni PC, Munin E, Ambrosano GM, Lovadino JR. In vitro evaluation of the effectiveness of bleaching agents activated by different light sources J Prosthodont 2009; 18 (3) : 249-54. J Esthet Restor Dent Ishikawa-Nagai S 16 368 2004 Ishikawa-Nagai S, Terui T, Ishibashi K, Weber HP, Ferguson M. Comparison of effectiveness of two 10% carbamide peroxide tooth-bleaching systems using spectrophotometric measurements J Esthet Restor Dent 2004; 16 (6) : 368-76. J Prosthet Dent Kielbassa AM 101 92 2009 Kielbassa AM, Beheim-Schwarzbach NJ, Neumann K, Nat R, Zantner C. In vitro comparison of visual and computer-aided pre- and post-tooth shade determination using various home bleaching procedures J Prosthet Dent 2009; 101 (2) : 92-100. Int J Prosthodont Derdilopoulou FV 20 414 2007 Derdilopoulou FV, Zantner C, Neumann K, Kielbassa AM. Evaluation of visual and spectrophotometric shade analyses: a clinical comparison of 3758 teeth Int J Prosthodont 2007; 20 (4) : 414-6. J Dent Joiner A 32 3 2004 Joiner A. Tooth colour: a review of the literature J Dent 2004; 32 : 3-12. J Dent Res Paul S 81 578 2002 Paul S, Peter A, Pietrobon N, Hämmerle CH. Visual and spectrophotometric shade analysis of human teeth J Dent Res 2002; 81 (8) : 578-82. J Can Dent Assoc Tam L 65 201 1999 Tam L. Clinical trial of three 10% carbamide peroxide bleaching products J Can Dent Assoc 1999; 65 (4) : 201-5. J Esthet Restor Dent Pohjola RM 14 85 2002 Pohjola RM, Browning WD, Hackman ST, Myers ML, Downey MC. Sensitivity and tooth whitening agents J Esthet Restor Dent 2002; 14 (2) : 85-91. J Esthet Restor Dent Leonard RH 13 357 2001 Leonard RH, Bentley C, Eagle JC, Garland GE, Knight MC, Phillips C. Nightguard vital bleaching: a long-term study on efficacy, shade retention. Side-effects, and patients’ perception J Esthet Restor Dent 2001; 13 (6) : 357-69. A 14-month clinical study: J Dent Grobler SR 38 113 2010 Grobler SR, Hayward R, Wiese S, Moola MH. Spectrophotometric assessment of the effectiveness of Opalescence PF 10% A 14-month clinical study: J Dent 2010; 38 : 113-7. Am J Dent Karpinia KA 2002 Karpinia KA, Magnusson I, Sagel PA, Zhou X, Gerlach RW. Vital bleaching with two at-home professional systems Am J Dent 2002. 15 Spec No: 13A-18A International Commission on Illumination recommendations on uniform color space, color difference equations, psychometric color terms Supplement 2 to CIE publication 1978; 15 Paris: Bureau Central de la CIE Minolta Precise color communication. Osaka, Japan : Minolta, Co., Ltd 1994; 9242: pp. 4830-92. J Endod Horn D 24 786 1998 Horn D, Bulan-Brady J, Hicks M. Sphere spectrophotometer versus human evaluation of tooth shade J Endod 1998; 24 (12) : 786-90. American dental association council on scientific affairs acceptance program guidelines: dentist dispensed home-use tooth bleaching products. ADA 2006 Available from:http://www.ada.org/ada/seal/standards/guide_home_bleach.pdf (Retrieved on December 2009) Am J Dent Ferrari M 17 291 2004 Ferrari M, Kugel G, Cagidiaco MC, Barker ML, Gerlach RW. Clinical trial evaluating the peroxide concentration response of whitening strips over 28 days Am J Dent 2004; 17 (4) : 291-4. Compend Contin Educ Dent Gerlach RW 23 35 2002 Gerlach RW, Zhou X. Comparative clinical efficacy of two professional bleaching systems Compend Contin Educ Dent 2002; 23 (1A) : 35-41. Am J Dent Callan RS 21 17 2008 Callan RS, Browning WD, Downey MC, Brackett MG. Comparison of two low sensitivity whiteners Am J Dent 2008; 21 (1) : 17-20. Jpns J Cons Dent Toko T 41 985 1998 Toko T, Yaoita EMI, Saito Y, et al. Clinical results of the bleaching method for discolored vital teeth by using nite white excel Jpns J Cons Dent 1998; 41 : 985-1008. Nihon Uni Dent J Hagiwara Y 73 263 1999 Hagiwara Y, Otani K, Hinokiyama N, et al. Clinical trial of the decolored vital teeth whitening. Using the home bleaching “Nite White” Nihon Uni Dent J 1999; 73 : 263-73. J Am Dent Assoc Giniger M 136 383 2005 Giniger M, Macdonald J, Ziemba S, Felix H. The clinical performance of professionally dispensed bleaching gel with added amorphous calcium phosphate J Am Dent Assoc 2005; 136 (3) : 383-92. Quintessence Int Tam L 32 766 2001 Tam L. Effect of potassium nitrate and fluoride on carbamide peroxide bleaching Quintessence Int 2001; 32 (10) : 766-0. J Dent Joiner A 32 27 2004 Joiner A, Thakker G, Cooper Y. Evaluation of a 6% hydrogen peroxide tooth whitening gel on enamel and dentine microhardness in vitro J Dent 2004; 32 : 27-34. J Dent Res O’Brien WJ 64 940 1990 O’Brien WJ, Johnston WM, Fanian F. Double-layer color effects in porcelain systems J Dent Res 1990; 64 : 940-3. Dent Mater Vichi A 20 530 2004 Vichi A, Ferrari M, Davidson CL. Color and opacity variations in three different resin-based composite products after water aging Dent Mater 2004; 20 : 530-4.