TODENTJ-25-03-2019_TODENTJ-5-174 1553505292 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 11 4 2011 5 1 Matteo Erriu Serena Sanna Annalisa Nucaro Germano Orrù Valentino Garau Caterina Montaldo Objectives: Celiac disease (CD) is an autoimmune disorder that can be divided into typical and atypical forms. Atypical forms can show extraintestinal manifestations among which oral signs are very frequent. Considering that the pathogenesis of CD is related to a positivity to specific HLA-DQB1 haplotypes, we tested whether the presence of the HLA-DQB1*02 allele could be a hypothetical cause of the development of oral manifestations. Subjects and Methods: For this study was been examined the oral condition of 98 Sardinian patients, all affected by CD and all on a gluten-free diet for at least 1 year. Then was been determined each patient’s HLA-DQB1 haplotype and compared these results with clinical information. Results: The statistical analysis evidenced that the absence of the HLA-DQB1*02 allele predisposes to oral manifestations such as dental enamel defects (DED) and recurrent aphthous stomatitis (RAS) (Pvalue=5.98x10-05, OR = 0.23, CI: (0.10 - 0.45) per each copy of the HLA allele). Conclusions: These results showed that the presence of the HLA-DQB1*02 allele influences the development of oral signs in a dose-dependent manner and also how the HLA haplotype connected to oral signs could have a fundamental role for the diagnosis of atypical forms of CD. 11 4 2011 174 178 TODENTJ-5-174 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2011-7-27 2011-8-22 2011-8-30 2011-11-4 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601105010174 1553505292 https://opendentistryjournal.com/VOLUME/5/PAGE/174/ https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-174/TODENTJ-5-174.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-174/TODENTJ-5-174.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-174/TODENTJ-5-174.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-174/TODENTJ-5-174.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-174/TODENTJ-5-174.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-174/TODENTJ-5-174.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-174/TODENTJ-5-174.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-174/TODENTJ-5-174.xml Gut Clemente MG 52 218 2003 Clemente MG, De Virgiliis S, Kang JS, et al. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function Gut 2003; 52 (2 ) : 218-3. Dig Liver Dis Dieterich W 39 917 2007 Dieterich W, Schuppan D. Is gliadin harmful from the first morsel? Dig Liver Dis 2007; 39 (10 ) : 917-21. Ann Intern Med Alaedini A 142 289 2005 Alaedini A, Green PH. Narrative review: celiac disease: understanding a complex autoimmune disorder Ann Intern Med 2005; 142 (4 ) : 289-98. Adv Pediatr Barker JM 55 349 2008 Barker JM, Liu E. Celiac disease: pathophysiology, clinical manifestations, and associated autoimmune conditions Adv Pediatr 2008; 55 : 349-65. Dig Dis Losowsky MS 26 112 2008 Losowsky MS. A history of coeliac disease Dig Dis 2008; 26 (2 ) : 112-20. J Dent Res Pastore L 87 1100 2008 Pastore L, Campisi G, Compilato D, Lo Muzio L. Orally based diagnosis of celiac disease: current perspectives J Dent Res 2008; 87 (12 ) : 1100-7. Am J Gastroenterol Cassinotti A 104 195 2009 Cassinotti A, Birindelli S, Clerici M, et al. HLA and autoimmune digestive disease: a clinically oriented review for gastroenterologists Am J Gastroenterol 2009; 104 (1 ) : 195-217. BMC Gastroenterol Ludvigsson JF 9 57 2009 Ludvigsson JF, Brandt L, Montgomery SM. Symptoms and signs in individuals with serology positive for celiac disease but normal mucosa BMC Gastroenterol 2009; 9 : 57. Med Oral Patol Oral Cir Bucal da Silva PC 13 E559 2008 da Silva PC, de Almeida Pdel V, Machado MA, et al. Oral manifestations of celiac disease: A case report and review of the literature Med Oral Patol Oral Cir Bucal 2008; 13 (9) : E559-62. Gastroenterology Schuppan D 137 1912 2009 Schuppan D, Junker Y, Barisani D. Celiac disease: from pathogenesis to novel therapies Gastroenterology 2009; 137 (6) : 1912-33. Aliment Pharmacol Ther Kapitany A 24 395 2006 Kapitany A, Toth L, Tumpek J, et al. Diagnostic significance of HLA-DQ typing in patients with previous coeliac disease diagnosis based on histology alone Aliment Pharmacol Ther 2006; 24 (9) : 395-402. Gut Hunt KA 58 473 2009 Hunt KA, van Heel DA. Recent advances in coeliac disease genetics Gut 2009; 58 (4) : 473-6. Scand J Gastroenterol Jores RD 42 48 2007 Jores RD, Frau F, Cucca F, et al. HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease Scand J Gastroenterol 2007; 42 (1) : 48-53. Coll Antropol Vona G 21 461 1997 Vona G, Bitti PP, Succa V, et al. HLA phenotype and haplotype frequencies in Sardinia (Italy) Coll Antropol 1997; 21 (2) : 461-75. Am J Hum Genet Marrosu MG 61 454 1997 Marrosu MG, Murru MR, Costa G, et al. Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and -DR4 alleles Am J Hum Genet 1997; 61 (2) : 454-7. Exp Gerontol Scola L 43 114 2008 Scola L, Lio D, Candore G, et al. Analysis of HLA-DRB1, DQA1, DQB1 haplotypes in Sardinian centenarians Exp Gerontol 2008; 43 (2) : 114-8. Scand J Immunol Lahteenoja H 52 602 2000 Lahteenoja H, Toivanen A, Viander M, et al. Increase in T-cell subsets of oral mucosa: a late immune response in patients with treated coeliac disease? Scand J Immunol 2000; 52 (6) : 602-8. J Oral Pathol Med Campisi G 38 34 2009 Campisi G, Compilato D, Iacono G, et al. Histomorphology of healthy oral mucosa in untreated celiac patients: unexpected association with spongiosis J Oral Pathol Med 2009; 38 (1) : 34-41. Curr Opin Gastroenterol Armstrong MJ 25 100 2009 Armstrong MJ, Robins GG, Howdle PD. Recent advances in coeliac disease Curr Opin Gastroenterol 2009; 25 (2) : 100-9. Rom J Gastroenterol Mulder CJ 11 179 2002 Mulder CJ, Hadithi MM, Rostami K, Goerres MS. Coeliac disease--has the time come for routine mass screening? in 2002-2010-2020? Rom J Gastroenterol 2002; 11 (3) : 179-82. Best Pract Res Clin Gastroenterol Mearin ML 19 441 2005 Mearin ML, Ivarsson A, Dickey W. Coeliac disease: is it time for mass screening? Best Pract Res Clin Gastroenterol 2005; 19 (3) : 441-52. JAMA Ludvigsson JF 302 1171 2009 Ludvigsson JF, Montgomery SM, Ekbom A, Brandt L, Granath F. Small-intestinal histopathology and mortality risk in celiac disease JAMA 2009; 302 (11) : 1171-8. Best Pract Res Clin Gastroenterol Brousse N 19 401 2005 Brousse N, Meijer JW. Malignant complications of coeliac disease Best Pract Res Clin Gastroenterol 2005; 19 (3) : 401-12. Dig Liver Dis Sugai E 42 352 2010 Sugai E, Nachman F, Vaquez H, et al. Dynamics of celiac disease-specific serology after initiation of a gluten-free diet and use in the assessment of compliance with treatment Dig Liver Dis 2010; 42 (5) : 352-8. J Clin Gastroenterol Malahias T 44 191 2010 Malahias T, Cheng J, Brar P, Minaya MT, Green PH. The association between celiac disease, dental enamel defects, and aphthous ulcers in a United States cohort J Clin Gastroenterol 2010; 44 (3) : 191-4. J Clin Gastroenterol Pastore L 42 224 2008 Pastore L, Carroccio A, Compilato D, Panzarella V, Serpico R, Lo Muzio L. Oral manifestations of celiac disease J Clin Gastroenterol 2008; 42 (3) : 224-32. Lancet Ballinger A 343 230 1994 Ballinger A, Hughes C, Kumar P, Hutchinson I, Clark M. Dental enamel defects in coeliac disease Lancet 1994; 343 (8891) : 230-1. Int J Paediatr Dent Wierink CD 17 163 2007 Wierink CD, van Diermen DE, Aartman IH, Heymans HS. Dental enamel defects in children with coeliac disease Int J Paediatr Dent 2007; 17 (3) : 163-8. J Oral Pathol Med Aine L 19 241 1990 Aine L, Maki M, Collin P, Keyrilainen O. Dental enamel defects in celiac disease J Oral Pathol Med 1990; 19 (6) : 241-5. Minerva Stomatol Erriu M 59 477 2010 Erriu M, Boscarelli F, Peluffo C, et al. A rapid sample method for HLA haplotype typization. a preliminary study on celiac patients Minerva Stomatol 2010; 59 (9) : 477-87. Gastroenterology Liu E 128 S33 2005 Liu E, Rewers M, Eisenbarth GS. Genetic testing: who should do the testing and what is the role of genetic testing in the setting of celiac disease? Gastroenterology 2005; 128 (4 Suppl 1) : S33-7. Mol Genet Metab Clot F 71 76 2000 Clot F, Babron MC. Genetics of celiac disease Mol Genet Metab 2000; 71 (1-2) : 76-80. J Am Diet Assoc Niewinski MM 108 661 2008 Niewinski MM. Advances in celiac disease and gluten-free diet J Am Diet Assoc 2008; 108 (4) : 661-72. Med Oral Patol Oral Cir Bucal Mina S 13 E398 2008 Mina S, Azcurra AI, Riga C, Cornejo LS, Brunotto M. Evaluation of clinical dental variables to build classifiers to predict celiac disease Med Oral Patol Oral Cir Bucal 2008; 13 (7) : E398-402. Am J Gastroenterol Wolters VM 103 90 2008 Wolters VM, Wijmenga C. Genetic background of celiac disease and its clinical implications Am J Gastroenterol 2008; 103 (1) : 90-5. Semin Immunol Heap GA 21 346 2009 Heap GA, van Heel DA. Genetics and pathogenesis of coeliac disease Semin Immunol 2009; 21 (6) : 346-54. PLoS One Helmerhorst EJ 5 e13264 2010 Helmerhorst EJ, Zamakhchari M, Schuppan D, Oppenheim FG. Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity PLoS One 2010; 5 (10) : e13264. Am J Gastroenterol Lahteenoja H 95 2880 2000 Lahteenoja H, Maki M, Viander M, et al. Local challenge on oral mucosa with an alpha-gliadin related synthetic peptide in patients with celiac disease Am J Gastroenterol 2000; 95 (10) : 2880-7. Best Pract Res Clin Gastroenterol van Heel DA 19 323 2005 van Heel DA, Hunt K, Greco L, Wijmenga C. Genetics in coeliac disease Best Pract Res Clin Gastroenterol 2005; 19 (3) : 323-9. J Immunol Methods Reinton N 316 125 2006 Reinton N, Helgheim A, Shegarfi H, Moghaddam A. A one-step real-time PCR assay for detection of DQA1*05, DQB1*02 and DQB1*0302 to aid diagnosis of celiac disease J Immunol Methods 2006; 316 (1-2) : 125-32.