TODENTJ-25-03-2019_TODENTJ-5-168 1553505288 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 11 4 2011 5 1 Reza Birang Mohammad Tavakoli Mohammad Shahabouei Alireza Torabi Ali Dargahi Ahmad Soolari Introduction: Faster reconstruction of patients’ masticatory systems is the aim of modern dentistry. A number of studies have indicated that application of growth factors to the surface of a dental implant leads to accelerated and enhanced osseointegration. The objective of the present study was to investigate the effect of plasma rich in growth factors on peri-implant bone healing. Materials and Methods: For the purpose of this study, two healthy, mixed-breed canines were selected, and the premolars were extracted from both sides of the mandible. Three months after premolar removal, 12 implants, each 5 mm in diameter and 10 mm in length, were placed in osteotomy sites on both sides of the mandible. Prior to placement, plasma rich in growth factors was applied to the surfaces of six implants, while the other six were used without plasma rich in growth factors. The implants were removed after 12 weeks along with the bone surrounding the sites using a trephine bur. One mesiodistal section containing the surrounding bone from each implant block, 50 µm in diameter, was prepared for histologic and histomorphometric investigation with an optical microscope. Results: The sites with implants treated with plasma rich in growth factors showed more bone-to-implant contact compared to control sites. Also, higher values for bone trabecular thickness and bone maturity were recorded for the PRGF-treated sites than for the control sites. Conclusion: Application of plasma rich in growth factors to the surface of an implant may enhance the bone healing process as well as bone-to-implant contact, thereby helping to achieve faster osseointegration. 11 4 2011 168 173 TODENTJ-5-168 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2011-7-19 2011-9-21 2011-9-21 2011-11-4 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601105010168 1553505288 https://opendentistryjournal.com/VOLUME/5/PAGE/168/ https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-168/TODENTJ-5-168.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-168/TODENTJ-5-168.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-168/TODENTJ-5-168.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-168/TODENTJ-5-168.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-168/TODENTJ-5-168.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-168/TODENTJ-5-168.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-168/TODENTJ-5-168.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-168/TODENTJ-5-168.xml Misch CE. 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