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        <full_title>The Open Dentistry Journal</full_title>
        <abbrev_title>TODENTJ</abbrev_title>
        <issn media_type="print">1874-2106</issn>
      </journal_metadata>
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        <publication_date media_type="print">
          <month>9</month>
          <day>16</day>
          <year>2011</year>
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        <journal_volume>
          <volume>5</volume>
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        <issue>1</issue>
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        <titles>
          <title>Self Reported Halitosis in Relation to Glycated Hemoglobin Level in Diabetic Patients</title>
        </titles>
        <contributors>
          <person_name contributor_role="author" sequence="first">
            <given_name>Mohammad S</given_name>
            <surname>Al-Zahrani</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Khalid H</given_name>
            <surname>Zawawi</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Obadah N</given_name>
            <surname>Austah</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Hamed S</given_name>
            <surname>Al-Ghamdi</surname>
          </person_name>
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        <jats:abstract>
                <jats:sec>
                    <jats:title>Objective:</jats:title>
                    <jats:p>This study was conducted to examine the relationship between the glycated hemoglobin level (HbA1c) and halitosis status among diabetic patients affected with periodontitis and to examine if there is a relationship between halitosis and different periodontal parameters. </jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Methods and Materials:</jats:title>
                    <jats:p>Consecutive type 2 diabetic patients were recruited from patients presented for treatment at a University hospital. Age, gender and smoking were recorded. A structured questionnaire on patients’ perception of their oral health, halitosis and diabetes severity and control was completed. Peripheral blood samples were obtained and analyzed for HbA1c levels. In addition, periodontal clinical parameters including probing depth, clinical attachment level, bleeding on probing and plaque scores were recorded. </jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Results:</jats:title>
                    <jats:p>A total of 38 type 2 diabetic patients were selected. The mean age was 52.1 (±8.8) years. Sixteen subjects (42.1%) reported halitosis. Of these, 62.5% were females, and only one subject was a current smoker. The mean levels of HbA1c were significantly different between those with and without halitosis, mean 9.6 (±2) and 8.2 (±1.6), respectively (p=0.03). No significant differences were found in the mean periodontal parameters between those with and without halitosis. </jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Conclusion:</jats:title>
                    <jats:p>The results of this study suggest an association between halitosis and increased levels of HbA1c. Further studies are needed to explain the nature of this association.</jats:p>
                </jats:sec>
            </jats:abstract>
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        <citation_list>
          <citation key="refR1">
            <journal_title>J Periodontol</journal_title>
            <author>Tonzetich J</author>
            <volume>48</volume>
            <first_page>13</first_page>
            <cYear>1977</cYear>
            <unstructured_citation>
                    Tonzetich J. 
                    Production and origin of oral malodor: a review of mechanisms and methods of analysis 
                    J Periodontol  
                    1977; 
                    48
                    : 13-20.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR2">
            <journal_title>Oral Surg Oral Med Oral Pathol</journal_title>
            <author>Tonzetich J</author>
            <volume>42</volume>
            <first_page>172</first_page>
            <cYear>1976</cYear>
            <unstructured_citation>
                    Tonzetich J, Ng SK. 
                    Reduction of malodor by oral cleansing procedures 
                    Oral Surg Oral Med Oral Pathol  
                    1976; 
                    42
                    : 172-81.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR3">
            <journal_title>Int J Dent Hyg</journal_title>
            <author>Rayman S</author>
            <volume>6</volume>
            <first_page>2</first_page>
            <cYear>2008</cYear>
            <unstructured_citation>
                    Rayman S, Almas K. 
                    Halitosis among racially diverse populations: an update 
                    Int J Dent Hyg  
                    2008; 
                    6
                    : 2-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR4">
            <journal_title>J Dent</journal_title>
            <author>Al-Ansari JM</author>
            <volume>34</volume>
            <first_page>444</first_page>
            <cYear>2006</cYear>
            <unstructured_citation>
                    Al-Ansari JM, Boodai H, Al-Sumait N, Al-Khabbaz AK, Al-Shammari KF, Salako N. 
                    Factors associated with self-reported halitosis in Kuwaiti patients 
                    J Dent  
                    2006; 
                    34
                    : 444-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR5">
            <journal_title>J Clin Periodontol</journal_title>
            <author>Liu XN</author>
            <volume>33</volume>
            <first_page>31</first_page>
            <cYear>2006</cYear>
            <unstructured_citation>
                    Liu XN, Shinada K, Chen XC, Zhang BX, Yaegaki K, Kawaguchi Y. 
                    Oral malodor-related parameters in the Chinese general population 
                    J Clin Periodontol  
                    2006; 
                    33
                    : 31-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR6">
            <journal_title>Cochrane Database Syst Rev</journal_title>
            <author>Outhouse TL</author>
            <first_page>CD005519</first_page>
            <cYear>2006</cYear>
            <unstructured_citation>
                    Outhouse TL, Al-Alawi R, Fedorowicz Z, Keenan JV. 
                    Tongue scraping for treating halitosis 
                    Cochrane Database Syst Rev  
                    2006; 
                    (Issue 2): 
                    CD005519.
                </unstructured_citation>
          </citation>
          <citation key="refR7">
            <journal_title>J Contemp Dent Pract</journal_title>
            <author>Sanz M</author>
            <volume>2</volume>
            <first_page>1</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Sanz M, Roldan S, Herrera D. 
                    Fundamentals of breath malodour 
                    J Contemp Dent Pract  
                    2001; 
                    2
                    : 1-17.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR8">
            <journal_title>Oral Health</journal_title>
            <author>Tessier JF</author>
            <volume>81</volume>
            <first_page>19</first_page>
            <cYear>1991</cYear>
            <unstructured_citation>
                    Tessier JF, Kulkarni GV. 
                    Bad breath: etiology, diagnosis and treatment 
                    Oral Health  
                    1991; 
                    81
                    : 19-22, 24.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR9">
            <journal_title>Acta Otorhinolaryngol Belg</journal_title>
            <author>Delanghe G</author>
            <volume>51</volume>
            <first_page>43</first_page>
            <cYear>1997</cYear>
            <unstructured_citation>
                    Delanghe G, Ghyselen J, Feenstra L, van Steenberghe D. 
                    Experiences of a Belgian multidisciplinary breath odour clinic 
                    Acta Otorhinolaryngol Belg  
                    1997; 
                    51
                    : 43-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR10">
            <journal_title>J Periodontol</journal_title>
            <author>Miyazaki H</author>
            <volume>66</volume>
            <first_page>679</first_page>
            <cYear>1995</cYear>
            <unstructured_citation>
                    Miyazaki H, Sakao S, Katoh Y, Takehara T. 
                    Correlation between volatile sulphur compounds and certain oral health measurements in the general population 
                    J Periodontol  
                    1995; 
                    66
                    : 679-84.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR11">
            <journal_title>J Periodontal Res</journal_title>
            <author>Yaegaki K</author>
            <volume>27</volume>
            <first_page>233</first_page>
            <cYear>1992</cYear>
            <unstructured_citation>
                    Yaegaki K, Sanada K. 
                    Volatile sulfur compounds in mouth air from clinically healthy subjects and patients with periodontal disease 
                    J Periodontal Res  
                    1992; 
                    27
                    : 233-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR12">
            <journal_title>Oral Surg Oral Med Oral Pathol</journal_title>
            <author>Schmidt NF</author>
            <volume>45</volume>
            <first_page>560</first_page>
            <cYear>1978</cYear>
            <unstructured_citation>
                    Schmidt NF, Missan SR, Tarbet WJ. 
                    The correlation between organoleptic mouth-odor ratings and levels of volatile sulfur compounds 
                    Oral Surg Oral Med Oral Pathol  
                    1978; 
                    45
                    : 560-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR13">
            <journal_title>Eur J Oral Sci</journal_title>
            <author>Waler SM</author>
            <volume>105</volume>
            <first_page>534</first_page>
            <cYear>1997</cYear>
            <unstructured_citation>
                    Waler SM. 
                    On the transformation of sulfur-containing amino acids and peptides to volatile sulfur compounds (VSC) in the human mouth 
                    Eur J Oral Sci  
                    1997; 
                    105
                    : 534-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR14">
            <journal_title>J Clin Periodontol</journal_title>
            <author>Tangerman A</author>
            <volume>34</volume>
            <first_page>748</first_page>
            <cYear>2007</cYear>
            <unstructured_citation>
                    Tangerman A, Winkel EG. 
                    Intra- and extra-oral halitosis: finding of a new form of extra-oral blood-borne halitosis caused by dimethyl sulphide 
                    J Clin Periodontol  
                    2007; 
                    34
                    : 748-55.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR15">
            <journal_title>J Periodontol</journal_title>
            <author>Yaegaki K</author>
            <volume>63</volume>
            <first_page>783</first_page>
            <cYear>1992</cYear>
            <unstructured_citation>
                    Yaegaki K, Sanada K. 
                    Biochemical and clinical factors influencing oral malodor in periodontal patients 
                    J Periodontol  
                    1992; 
                    63
                    : 783-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR16">
            <journal_title>Can Med Assoc J</journal_title>
            <author>Attia EL</author>
            <volume>126</volume>
            <first_page>1281</first_page>
            <cYear>1982</cYear>
            <unstructured_citation>
                    Attia EL, Marshall KG. 
                    Halitosis 
                    Can Med Assoc J  
                    1982; 
                    126
                    : 1281-5.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR17">
            <journal_title>Int Dent J</journal_title>
            <author>Tangerman A</author>
            <volume>52</volume>
            <first_page>201</first_page>
            <cYear>2002</cYear>
            <unstructured_citation>
                    Tangerman A. 
                    Halitosis in medicine: a review 
                    Int Dent J  
                    2002; 
                    52
                    (Suppl 3)
                    : 201-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR18">
            <journal_title>Compend Contin Educ Dent</journal_title>
            <author>Taylor GW</author>
            <volume>25</volume>
            <first_page>179</first_page>
            <cYear>2004</cYear>
            <unstructured_citation>
                    Taylor GW, Manz MC, Borgnakke WS. 
                    Diabetes, periodontal diseases, dental caries, and tooth loss: a review of the literature 
                    Compend Contin Educ Dent  
                    2004; 
                    25
                    : 179-84.
                    
                    
                 186-8, 190: quiz 92</unstructured_citation>
          </citation>
          <citation key="refR19">
            <journal_title>Diabetes Metab</journal_title>
            <author>Soell M</author>
            <volume>33</volume>
            <first_page>S10</first_page>
            <cYear>2007</cYear>
            <unstructured_citation>
                    Soell M, Hassan M, Miliauskaite A, Haikel Y, Selimovic D. 
                    The oral cavity of elderly patients in diabetes 
                    Diabetes Metab  
                    2007; 
                    33
                    (Suppl 1)
                    : S10-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR20">
            <journal_title>J Periodontol</journal_title>
            <author>Mealey BL</author>
            <volume>77</volume>
            <first_page>1289</first_page>
            <cYear>2006</cYear>
            <unstructured_citation>
                    Mealey BL, Oates TW. 
                    Diabetes mellitus and periodontal diseases 
                    J Periodontol  
                    2006; 
                    77
                    : 1289-303.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR21">
            <journal_title>Ann Periodontol</journal_title>
            <author>Grossi SG</author>
            <volume>3</volume>
            <first_page>51</first_page>
            <cYear>1998</cYear>
            <unstructured_citation>
                    Grossi SG, Genco RJ. 
                    Periodontal disease and diabetes mellitus: a two-way relationship 
                    Ann Periodontol  
                    1998; 
                    3
                    : 51-61.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR22">
            <journal_title>Ann Periodontol</journal_title>
            <author>Taylor GW</author>
            <volume>6</volume>
            <first_page>99</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Taylor GW. 
                    Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective 
                    Ann Periodontol  
                    2001; 
                    6
                    : 99-112.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR23">
            <journal_title>J Am Dent Assoc</journal_title>
            <author>Lamster IB</author>
            <volume>139</volume>
            <first_page>19S</first_page>
            <cYear>2008</cYear>
            <unstructured_citation>
                    Lamster IB, Lalla E, Borgnakke WS, Taylor GW. 
                    The relationship between oral health and diabetes mellitus 
                    J Am Dent Assoc  
                    2008; 
                    139
                    (Suppl)
                    : 19S-24S.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR24">
            <journal_title>Diabetes Care</journal_title>
            <author>Loe H</author>
            <volume>16</volume>
            <first_page>329</first_page>
            <cYear>1993</cYear>
            <unstructured_citation>
                    Loe H. 
                    Periodontal disease. The sixth complication of diabetes mellitus 
                    Diabetes Care  
                    1993; 
                    16
                    : 329-4.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR25">
            <journal_title>Am J Gastroenterol</journal_title>
            <author>Vakil N</author>
            <volume>101</volume>
            <first_page>1900</first_page>
            <cYear>2006</cYear>
            <unstructured_citation>
                    Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. 
                    The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus 
                    Am J Gastroenterol  
                    2006; 
                    101
                    : 1900-20.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR26">
            <journal_title>Diabetes Technol Ther</journal_title>
            <author>Greiter MB</author>
            <volume>12</volume>
            <first_page>455</first_page>
            <cYear>2010</cYear>
            <unstructured_citation>
                    Greiter MB, Keck L, Siegmund T, Hoeschen C, Oeh U, Paretzke HG. 
                    Differences in exhaled gas profiles between patients with type 2 diabetes and healthy controls 
                    Diabetes Technol Ther  
                    2010; 
                    12
                    : 455-63.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR27">
            <journal_title>Diabetes Technol Ther</journal_title>
            <author>Galassetti PR</author>
            <volume>7</volume>
            <first_page>115</first_page>
            <cYear>2005</cYear>
            <unstructured_citation>
                    Galassetti PR, Novak B, Nemet D, et al. 
                    Breath ethanol and acetone as indicators of serum glucose levels: an initial report 
                    Diabetes Technol Ther  
                    2005; 
                    7
                    : 115-23.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR28">
            <journal_title>Proc Natl Acad Sci U S A</journal_title>
            <author>Novak BJ</author>
            <volume>104</volume>
            <first_page>15613</first_page>
            <cYear>2007</cYear>
            <unstructured_citation>
                    Novak BJ, Blake DR, Meinardi S, et al. 
                    Exhaled methyl nitrate as a noninvasive marker of hyperglycemia in type 1 diabetes 
                    Proc Natl Acad Sci U S A  
                    2007; 
                    104
                    : 15613-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR29">
            <journal_title>Int J Clin Pract</journal_title>
            <author>Visvanathan V</author>
            <volume>64</volume>
            <first_page>404</first_page>
            <cYear>2010</cYear>
            <unstructured_citation>
                    Visvanathan V, Nix P. 
                    Managing the patient presenting with xerostomia: a review 
                    Int J Clin Pract  
                    2010; 
                    64
                    : 404-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR30">
            <journal_title>J Appl Oral Sci</journal_title>
            <author>Casemiro LA</author>
            <volume>16</volume>
            <first_page>271</first_page>
            <cYear>2008</cYear>
            <unstructured_citation>
                    Casemiro LA, Martins CH, de Carvalho TC, Panzeri H, Lavrador MA, Pires-de-Souza Fde C. 
                    Effectiveness of a new toothbrush design versus a conventional tongue scraper in improving breath odor and reducing tongue microbiota 
                    J Appl Oral Sci  
                    2008; 
                    16
                    : 271-4.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR31">
            <journal_title>J Dent Res</journal_title>
            <author>Rosenberg M</author>
            <volume>74</volume>
            <first_page>1577</first_page>
            <cYear>1995</cYear>
            <unstructured_citation>
                    Rosenberg M, Kozlovsky A, Gelernter I, et al. 
                    Self-estimation of oral malodor 
                    J Dent Res  
                    1995; 
                    74
                    : 1577-82.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR32">
            <journal_title>Oral Dis</journal_title>
            <author>Iwanicka-Grzegorek E</author>
            <volume>11</volume>
            <first_page>86</first_page>
            <cYear>2005</cYear>
            <unstructured_citation>
                    Iwanicka-Grzegorek E, Michalik J, Kepa J, Wierzbicka M, Aleksinski M, Pierzynowska E. 
                    Subjective patients' opinion and evaluation of halitosis using halimeter and organoleptic scores 
                    Oral Dis  
                    2005; 
                    11
                    (Suppl 1)
                    : 86-.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR33">
            <journal_title>J Dent</journal_title>
            <author>van den Broek AM</author>
            <volume>35</volume>
            <first_page>627</first_page>
            <cYear>2007</cYear>
            <unstructured_citation>
                    van den Broek AM, Feenstra L, de Baat C. 
                    A review of the current literature on aetiology and measurement methods of halitosis 
                    J Dent  
                    2007; 
                    35
                    : 627-35.
                    
                </unstructured_citation>
          </citation>
        </citation_list>
      </journal_article>
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