TODENTJ-25-03-2019_TODENTJ-5-105 1553505258 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 7 7 2011 5 1 Sarah A Alfaqeeh Sukumaran Anil Objectives: This study aims at analyzing the changes in gingival crevicular fluid (GCF) lactate dehydrogenase (LDH) activity during orthodontic movement. Methods: Twenty patients all requiring first premolar extractions were selected and treated with conventional straight wire mechanotherapy. Canine retraction was done using 125 g Nitinol closed coil springs. The maxillary canine on one side served as the experimental site while the contralateral canine served as the control. GCF was collected from the canines before initiation of retraction, then 1 hour after initiating canine retraction, followed by 1 day, 7 days, 14 days and 21 days. GCF LDH levels were estimated and compared with the control site. Results The results revealed significantly higher LDH levels on the 7th, 14th and 21st day at the sites where orthodontic force had been applied. The levels also showed a significant increase from 0 hour to the 21st day. Peak levels were seen on 14th and 21st day following initiation of retraction. Conclusions: The study showed that LDH could be successfully estimated in the GCF and its increased levels could indicate active tooth movement, which could aid the clinician in monitoring active orthodontic tooth movement. 7 7 2011 105 109 TODENTJ-5-105 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2011-1-20 2011-4-6 2011-4-8 2011-7-7 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601105010105 1553505258 https://opendentistryjournal.com/VOLUME/5/PAGE/105/ https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-105/TODENTJ-5-105.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-105/TODENTJ-5-105.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-105/TODENTJ-5-105.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-105/TODENTJ-5-105.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-105/TODENTJ-5-105.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-105/TODENTJ-5-105.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-105/TODENTJ-5-105.pdf https://opendentistryjournal.com/contents/volumes/V5/TODENTJ-5-105/TODENTJ-5-105.xml Int J Adult Orthodon Orthognath Surg Kavadia-Tsatala S 17 191 2002 Kavadia-Tsatala S, Kaklamanos EG, Tsalikis L. 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