TODENTJ-25-03-2019_TODENTJ-4-72 1553505156 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 7 16 2010 4 1 Ralf Bender The number needed to treat (NNT) is a popular effect measure to present study results in biomedical research. NNTs were originally proposed to describe the absolute effect of a new treatment compared with a standard treatment or placebo in randomized controlled trials (RCTs) with binary outcome. The concept of the NNT measure has been applied to a number of other research areas involving the development of related measures and more sophisticated techniques to calculate and interpret NNT measures in biomedical research. In epidemiology and public health research an adequate adjustment for covariates is usually required leading to the application of adjusted NNT measures. An overview of the recent developments regarding adjustment of NNT measures is given. The use and interpretation of adjusted NNT measures is illustrated by means of examples from dentistry research. 7 16 2010 72 76 TODENTJ-4-72 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2009-9-25 2009-10-14 2009-10-14 2010-7-16 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601004010072 1553505156 https://opendentistryjournal.com/VOLUME/4/PAGE/72/ https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-72/TODENTJ-4-72.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-72/TODENTJ-4-72.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-72/TODENTJ-4-72.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-72/TODENTJ-4-72.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-72/TODENTJ-4-72.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-72/TODENTJ-4-72.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-72/TODENTJ-4-72.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-72/TODENTJ-4-72.xml Bender R. 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