Experimental Animal Models in Periodontology: A Review

TODENTJ-25-03-2019_TODENTJ-4-37 1553505144 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 4 29 2010 4 1 Experimental Animal Models in Periodontology: A Review Xavier Struillou Hervé Boutigny Assem Soueidan Pierre Layrolle In periodontal research, animal studies are complementary to in vitro experiments prior to testing new treatments. Animal models should make possible the validation of hypotheses and prove the safety and efficacy of new regenerating approaches using biomaterials, growth factors or stem cells. A review of the literature was carried out by using electronic databases (PubMed, ISI Web of Science). Numerous animal models in different species such as rats, hamsters, rabbits, ferrets, canines and primates have been used for modeling human periodontal diseases and treatments. However, both the anatomy and physiopathology of animals are different from those of humans, making difficult the evaluation of new therapies. Experimental models have been developed in order to reproduce major periodontal diseases (gingivitis, periodontitis), their pathogenesis and to investigate new surgical techniques. The aim of this review is to define the most pertinent animal models for periodontal research depending on the hypothesis and expected results. 4 29 2010 37 47 TODENTJ-4-37 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2009-12-10 2010-1-19 2010-2-3 2010-4-29 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601004010037 1553505144 https://opendentistryjournal.com/VOLUME/4/PAGE/37/ https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-37/TODENTJ-4-37.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-37/TODENTJ-4-37.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-37/TODENTJ-4-37.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-37/TODENTJ-4-37.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-37/TODENTJ-4-37.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-37/TODENTJ-4-37.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-37/TODENTJ-4-37.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-37/TODENTJ-4-37.xml Tissue Eng Part A Tobita M 14 945 2008 Tobita M, Uysal AC, Ogawa R, Hyakusoku H, Mizuno H. 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