TODENTJ-25-03-2019_TODENTJ-4-230 1553505218 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 12 31 2010 4 1 Shihoko Sakuma Akihiro Yoshihara Hideo Miyazaki Seigo Kobayashi Background: In Niigata prefecture, Japan, a system has been developed based on a school-based fluoride mouth rinse program as follows; students with caries susceptible teeth are screened in a school dental examination, and encouraged to receive sealant placement in local dental clinics. However, the cost-effectiveness of sealant application in the public health has been questioned. The aim of this study was to estimate of the cost-effectiveness and cost-benefit ratio for a school-based combined program with fluoride mouth rinse and targeted fissure sealant in children residing in non-fluoridated areas in Japan. Participants: The analysis was based on comparing an intervention group with two cohorts in the 8-year-old (n=66) and 11-year-old (n=58) participating in the combined program for four and seven years, respectively, with a control group of the same grades (n=43 and n=54 respectively). Methods: The study measured mean differences in number of decayed and filled teeth (DFT) between the study groups and a combined program cost per child during study periods. The cost-effectiveness ratio was expressed as an individual annual program cost per DFT averted. In the cost-benefit ratio the mean difference in treatment cost between groups (program benefit) was compared to program cost. Results: The mean reduced DFT differences between groups were 1.44 in 8-year-old and 3.17 in 11-year-old children. The cost-effectiveness ratio was ¥ 493 in the 8-year-old and ¥ 202 in the 11-year-old, respectively. The cost-benefit ratio was 1.84 in 8-year-old children and 2.42 in 11-year-old. Conclusion: This combined program indicated acceptable cost-effectiveness and cost –benefit ratio. 12 31 2010 230 236 TODENTJ-4-230 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2010-5-10 2010-8-5 2010-9-2 2010-12-31 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601004010230 1553505218 https://opendentistryjournal.com/VOLUME/4/PAGE/230/ https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-230/TODENTJ-4-230.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-230/TODENTJ-4-230.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-230/TODENTJ-4-230.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-230/TODENTJ-4-230.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-230/TODENTJ-4-230.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-230/TODENTJ-4-230.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-230/TODENTJ-4-230.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-230/TODENTJ-4-230.xml Cochrane Database of Systematic Reviews Ahovuo-Saloranta A 2004 Ahovuo-Saloranta A, Hiiri A, Nordblad A, Worthington H, Mäkelä M. 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