TODENTJ-25-03-2019_TODENTJ-4-195 1553505204 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 10 21 2010 4 1 Po Hsien Huang Yih Chuen Shyng P Sloan Keng-Liang Ou Y. J. Hsia H. Devlin Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck region, especially among those of Chinese origin. NPC has multifactorial aetiologies including genetic susceptibility, consumption of food with high salt content, and the Epstein–Barr virus. The primary tumour usually arises from the lateral walls of the nasopharynx and is characterized by a rich sub-mucosal lymphatic structure, often leading to cervical lymph node metastasis. Distant metastasis has been recognized to be a major cause of treatment failure in patients with nasopharyngeal carcinoma. Bone, liver and lung are the most frequent sites of NPC metastases. 10 21 2010 195 197 TODENTJ-4-195 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2010-2-18 2010-8-12 2010-8-16 2010-10-21 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601004010195 1553505204 https://opendentistryjournal.com/VOLUME/4/PAGE/195/ https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-195/TODENTJ-4-195.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-195/TODENTJ-4-195.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-195/TODENTJ-4-195.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-195/TODENTJ-4-195.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-195/TODENTJ-4-195.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-195/TODENTJ-4-195.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-195/TODENTJ-4-195.pdf https://opendentistryjournal.com/contents/volumes/V4/TODENTJ-4-195/TODENTJ-4-195.xml Quintessence Int Khan J 41 387 2010 Khan J, Quek SY, Markman S. 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