<?xml version="1.0"?>
<doi_batch xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://www.crossref.org/schema/4.4.0" xmlns:fr="http://www.crossref.org/fundref.xsd" xmlns:ct="http://www.crossref.org/clinicaltrials.xsd" xmlns:ai="http://www.crossref.org/AccessIndicators.xsd" xmlns:rel="http://www.crossref.org/relations.xsd" xmlns:jats="http://www.ncbi.nlm.nih.gov/JATS1" version="4.4.0" xsi:schemaLocation="http://www.crossref.org/schema/4.4.0 crossref4.4.0.xsd">
  <head>
    <doi_batch_id>TODENTJ-25-03-2019_TODENTJ-3-48</doi_batch_id>
    <timestamp>1553505044</timestamp>
    <depositor>
      <depositor_name>Bentham Open</depositor_name>
      <email_address>doi@benthamopen.net</email_address>
    </depositor>
    <registrant>Bentham Open</registrant>
  </head>
  <body>
    <journal>
      <journal_metadata language="en">
        <full_title>The Open Dentistry Journal</full_title>
        <abbrev_title>TODENTJ</abbrev_title>
        <issn media_type="print">1874-2106</issn>
      </journal_metadata>
      <journal_issue>
        <publication_date media_type="print">
          <month>4</month>
          <day>3</day>
          <year>2009</year>
        </publication_date>
        <journal_volume>
          <volume>3</volume>
        </journal_volume>
        <issue>1</issue>
      </journal_issue>
      <journal_article publication_type="full_text">
        <titles>
          <title>The Relationships between Two Different Drinking Water Fluoride Levels, Dental Fluorosis and Bone Mineral Density of Children</title>
        </titles>
        <contributors>
          <person_name contributor_role="author" sequence="first">
            <given_name>S.R</given_name>
            <surname>Grobler</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>A.J</given_name>
            <surname>Louw</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>U.M.E</given_name>
            <surname>Chikte</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>R.J</given_name>
            <surname>Rossouw</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>T.J. van W</given_name>
            <surname>Kotze</surname>
          </person_name>
        </contributors>
        <jats:abstract>
                <jats:p>This field study included the whole population of children aged 10–15 years (77 from a 0.19 mg/L F area; 89 from a 3.00 mg/L F area), with similar nutritional, dietary habits and similar ethnic and socioeconomic status. <jats:italic>The fluoride concentration in the drinking water, the bone mineral content, the bone density and the degree of dental fluorosis were determined</jats:italic>. The left radius was measured for bone width, bone mineral content, and bone mineral density. The mean fluorosis score was 1.3 in the low fluoride area and 3,6 in the high fluoride area. More than half the children in the low fluoride area had no fluorosis (scores 0 and 1) while only 5% in the high fluoride area had none. Severe fluorosis (30%) was only observed in the high fluoride area. The Wilcoxon Rank Sum Test indicated that fluorosis levels differed significantly (p &lt; 0.05) between the two areas. No relationships were found between dental fluorosis and bone width or between fluorosis and bone mineral density in the two areas (Spearment Rank correlations). A significant increase in bone width was found with age but no differences amongst and boys and girls. A significant positive correlation was found in the high fluoride area between bone mineral density over age. In the 12-13 and 13-14 year age groups in the high fluoride area, girls had higher bone mineral densities. However, a significant negative correlation (p&lt;0.02) was found for the low fluoride area (0.19 mg/L F) over age.</jats:p>
            </jats:abstract>
        <publication_date>
          <month>4</month>
          <day>3</day>
          <year>2009</year>
        </publication_date>
        <pages>
          <first_page>48</first_page>
          <last_page>54</last_page>
        </pages>
        <publisher_item>
          <identifier id_type="sici">TODENTJ-3-48</identifier>
        </publisher_item>
        <crossmark>
          <crossmark_version>1</crossmark_version>
          <crossmark_policy>10.2174/crossmark_policy</crossmark_policy>
          <crossmark_domains>
            <crossmark_domain>
              <domain>opendentistryjournal.com</domain>
            </crossmark_domain>
            <crossmark_domain>
              <domain>benthamopen.com</domain>
            </crossmark_domain>
          </crossmark_domains>
          <crossmark_domain_exclusive>true</crossmark_domain_exclusive>
          <custom_metadata>
            <assertion name="review_status" label="Review Status" group_name="peer_review_details" group_label="Peer Review Details" order="0">Peer Reviewed</assertion>
            <assertion name="review_process" label="Review Process" group_name="peer_review_details" group_label="Peer Review Details" order="1">Single blind</assertion>
            <assertion name="screening_status" label="Screening Status" group_name="plagiarism_screening" group_label="Plagiarism Screening" order="0">Checked with iThenticate</assertion>
            <assertion name="received" label="Received" group_name="publication_history" group_label="Publication History" order="0">2008-11-5</assertion>
            <assertion name="revised" label="Revised" group_name="publication_history" group_label="Publication History" order="1">2008-12-23</assertion>
            <assertion name="accepted" label="Accepted" group_name="publication_history" group_label="Publication History" order="2">2009-3-3</assertion>
            <assertion name="published" label="Published" group_name="publication_history" group_label="Publication History" order="3">2009-4-3</assertion>
            <ai:program name="AccessIndicators">
              <ai:license_ref>http: //creativecommons.org/licenses/by-nc/3.0/</ai:license_ref>
            </ai:program>
          </custom_metadata>
        </crossmark>
        <doi_data>
          <doi>10.2174/1874210600903010048</doi>
          <timestamp>1553505044</timestamp>
          <resource>https://opendentistryjournal.com/VOLUME/3/PAGE/48/</resource>
          <collection property="crawler-based">
            <item crawler="google">
              <resource>https://opendentistryjournal.com/contents/volumes/V3/TODENTJ-3-48/TODENTJ-3-48.pdf</resource>
            </item>
            <item crawler="msn">
              <resource>https://opendentistryjournal.com/contents/volumes/V3/TODENTJ-3-48/TODENTJ-3-48.pdf</resource>
            </item>
            <item crawler="altavista">
              <resource>https://opendentistryjournal.com/contents/volumes/V3/TODENTJ-3-48/TODENTJ-3-48.pdf</resource>
            </item>
            <item crawler="yahoo">
              <resource>https://opendentistryjournal.com/contents/volumes/V3/TODENTJ-3-48/TODENTJ-3-48.pdf</resource>
            </item>
            <item crawler="scirus">
              <resource>https://opendentistryjournal.com/contents/volumes/V3/TODENTJ-3-48/TODENTJ-3-48.pdf</resource>
            </item>
            <item crawler="iParadigms">
              <resource>https://opendentistryjournal.com/contents/volumes/V3/TODENTJ-3-48/TODENTJ-3-48.pdf</resource>
            </item>
          </collection>
          <collection property="text-mining">
            <item>
              <resource mime_type="application/pdf">https://opendentistryjournal.com/contents/volumes/V3/TODENTJ-3-48/TODENTJ-3-48.pdf</resource>
            </item>
            <item>
              <resource mime_type="application/xml">https://opendentistryjournal.com/contents/volumes/V3/TODENTJ-3-48/TODENTJ-3-48.xml</resource>
            </item>
          </collection>
        </doi_data>
        <citation_list>
          <citation key="refR1">
            <journal_title>J Fluor Chem</journal_title>
            <author>Harrison PTC</author>
            <volume>126</volume>
            <first_page>1448</first_page>
            <cYear>2005</cYear>
            <unstructured_citation>
                    Harrison PTC. 
                    Fluoride in water: A UK perspective 
                    J Fluor Chem  
                    2005; 
                    126
                    : 1448-56.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR2">
            <unstructured_citation>
                    Davies MJ, Spencer AJ. 
                    The child dental health survey Australia, 1993. AIHW DSRV 
                    1995.
                    
                 (Dental Statistics and Research Series No. 7)</unstructured_citation>
          </citation>
          <citation key="refR3">
            <journal_title>Int Dent J</journal_title>
            <author>Spencer AJ</author>
            <volume>44</volume>
            <first_page>415</first_page>
            <cYear>1994</cYear>
            <unstructured_citation>
                    Spencer AJ, Davies MJ, Slade GD, Brennan D. 
                    Caries prevalence in Australasia 
                    Int Dent J  
                    1994; 
                    44
                    : 415-23.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR4">
            <journal_title>Com Dent Health</journal_title>
            <author>Spencer AJ</author>
            <volume>2</volume>
            <first_page>27</first_page>
            <cYear>1996</cYear>
            <unstructured_citation>
                    Spencer AJ, Slade GD, Davies MJ. 
                    Water fluoridation in Australia 
                    Com Dent Health  
                    1996; 
                    2
                    : 27-37.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR5">
            <journal_title>Br Med J</journal_title>
            <author>Jones CM</author>
            <volume>15</volume>
            <first_page>514</first_page>
            <cYear>1997</cYear>
            <unstructured_citation>
                    Jones CM, Taylor GO, Whittle JG. 
                    Water fluoridation, tooth decay in 5 year olds, and social deprivation measured by the Jarman score. Analysis of data from the British dental surveys 
                    Br Med J  
                    1997; 
                    15
                    : 514-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR6">
            <journal_title>J Dent Assoc S Afr</journal_title>
            <author>Du Plessis JB</author>
            <volume>54</volume>
            <first_page>483</first_page>
            <cYear>1979</cYear>
            <unstructured_citation>
                    Du Plessis JB. 
                    The effect of socio-economic status on dental caries experience in 6, 12 and 15 year-old school children in Port Elizabeth and Dispatch 
                    J Dent Assoc S Afr  
                    1979; 
                    54
                    : 483-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR7">
            <journal_title>Inter. J Paeditr Dent</journal_title>
            <author>Grobler SR</author>
            <volume>11</volume>
            <first_page>372</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Grobler SR, Louw AJ, van Wyk Kotze TJ. 
                    Dental fluorosis and caries experience in relation to three different drinking water fluoride levels in South Africa 
                    Inter J Paeditr Dent  
                    2001; 
                    11
                    : 372-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR8">
            <journal_title>Caries Res</journal_title>
            <author>Grobler SR</author>
            <volume>20</volume>
            <first_page>284</first_page>
            <cYear>1986</cYear>
            <unstructured_citation>
                    Grobler SR, van Wyk Kotze CW, Kotze D. 
                    Relationship between enamel fluoride levels, degree of fluorosis and caries experience in communities with a nearly optimal and a high fluoride level in the drinking water 
                    Caries Res  
                    1986; 
                    20
                    : 284-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR9">
            <journal_title>Gen Dent</journal_title>
            <author>Louw AJ</author>
            <volume>13</volume>
            <first_page>352</first_page>
            <cYear>2002</cYear>
            <unstructured_citation>
                    Louw AJ, Grobler SR, van Wyk Kotze TJ. 
                    Degree of fluorosis in areas of South Africa with differing levels of fluoride in drinking water 
                    Gen Dent  
                    2002; 
                    13
                    : 352-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR10">
            <journal_title>J Dent Res</journal_title>
            <author>Manji F</author>
            <volume>65</volume>
            <first_page>659</first_page>
            <cYear>1986</cYear>
            <unstructured_citation>
                    Manji F, Baelum V, Fejerskov O. 
                    Dental fluorosis in an area of Kenia with 2 mg/L fluoride in the drinking water 
                    J Dent Res  
                    1986; 
                    65
                    : 659-2.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR11">
            <journal_title>Odontostomatol Trop</journal_title>
            <author>Aziz Ghandour IA</author>
            <volume>11</volume>
            <first_page>103</first_page>
            <cYear>1988</cYear>
            <unstructured_citation>
                    Aziz Ghandour IA, Ibrahim FA, Shehata AH. 
                    The prevalence of dental caries, fluorosis, and dental attitudes among primary schoolchildren in Omdurman-Sudan 
                    Odontostomatol Trop  
                    1988; 
                    11
                    : 103-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR12">
            <journal_title>Commun Dent Oral Epidemiol</journal_title>
            <author>Ng’ang’a PM</author>
            <volume>21</volume>
            <first_page>15</first_page>
            <cYear>1993</cYear>
            <unstructured_citation>
                    Ng’ang’a PM, Valderhaug J. 
                    Prevalence and severity of dental fluorosis in primary schoolchildren in Nairobi, Kenya 
                    Commun Dent Oral Epidemiol  
                    1993; 
                    21
                    : 15-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR13">
            <journal_title>J Am Diet Assoc</journal_title>
            <volume>105</volume>
            <first_page>1620</first_page>
            <cYear>2005</cYear>
            <unstructured_citation>
                ADA Association. 
                    Position of the American Dietetic Association: The impact of fluoride on health 
                    J Am Diet Assoc  
                    2005; 
                    105
                    : 1620-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR14">
            <journal_title>Bone</journal_title>
            <author>Lehmann R</author>
            <volume>22</volume>
            <first_page>273</first_page>
            <cYear>1998</cYear>
            <unstructured_citation>
                    Lehmann R, Wapniarz M, Hofmann B, Pieper B, Haubitz I, Allolio B. 
                    Drinking water fluoridation: Bone mineral density and hip fracture incidence 
                    Bone  
                    1998; 
                    22
                    : 273-8.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR15">
            <journal_title>Aust Dent J</journal_title>
            <author>Demos LL</author>
            <volume>46</volume>
            <first_page>80</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Demos LL, Kazda H, Cicuttini FM, Sinclair MI, Fairley CK. 
                    Water fluoridation, osteoporosis, fractures : recent developments 
                    Aust Dent J  
                    2001; 
                    46
                    : 80-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR16">
            <unstructured_citation>
                USA National Academy of Sciences, National Research Council. 
                    Fluoride in Drinking water Committee on Fluoride in Drinking Water: Report prepared by the National Research Council.  
                    500 Fifth Street, NW, Washington, DC. 20001: National Academies Press 2006; pp. 
                    (800): 
                    
                    
                    624-6242.
                    
                    
                 Academic press www.nap.edu</unstructured_citation>
          </citation>
          <citation key="refR17">
            <journal_title>Fluoride</journal_title>
            <author>Cao J</author>
            <volume>38</volume>
            <first_page>44</first_page>
            <cYear>2005</cYear>
            <unstructured_citation>
                    Cao J, Lui J, Tang L, Sangbu D, Yu S, Zhou S, et al. 
                    Dental and early-stage skeletal fluorosis in children induced by fluoride in brick-tea 
                    Fluoride  
                    2005; 
                    38
                    : 44-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR18">
            <unstructured_citation>
                    World Health Organization. 
                    Oral health surveys: Basic methods.  3rd ed. 
                    Geneva: WHO 1987.
                    
                    
                                        
                </unstructured_citation>
          </citation>
          <citation key="refR19">
            <journal_title>Anal Lett</journal_title>
            <author>Nicholson K</author>
            <volume>14A7</volume>
            <first_page>493</first_page>
            <cYear>1981</cYear>
            <unstructured_citation>
                    Nicholson K, Duff EJ. 
                    Fluoride determination in water 
                    Anal Lett  
                    1981; 
                    14A7
                    : 493-517.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR20">
            <journal_title>J Dent Assoc S Afr</journal_title>
            <author>Grobler SR</author>
            <volume>39</volume>
            <first_page>793</first_page>
            <cYear>1984</cYear>
            <unstructured_citation>
                    Grobler SR, Dreyer AG. 
                    Fluoride levels in the drinking water of South Africa and South West Africa 
                    J Dent Assoc S Afr  
                    1984; 
                    39
                    : 793-.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR21">
            <journal_title>J Dent Assoc S Afr</journal_title>
            <author>Grobler SR</author>
            <volume>46</volume>
            <first_page>571</first_page>
            <cYear>1991</cYear>
            <unstructured_citation>
                    Grobler SR, Kotze VW, Kotze TJ, Cleymaet R. 
                    Fluoride concentration in drinking water in small villages in the Cape province 
                    J Dent Assoc S Afr  
                    1991; 
                    46
                    : 571-4.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR22">
            <journal_title>Natl Oral Health Survey S Afr</journal_title>
            <author>Du Plessis JB</author>
            <volume>89</volume>
            <first_page>15</first_page>
            <cYear>1988</cYear>
            <unstructured_citation>
                    Du Plessis JB, Louw AJ, van der Merwe CA. 
                    Calibration of examiners for the National Oral Health Survey: Caries and periodontal diseases 
                    Natl Oral Health Survey S Afr  
                    1988; 
                    89
                    : 15-23.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR23">
            <journal_title>Educ Physiol Meas</journal_title>
            <author>Cohen J</author>
            <volume>20</volume>
            <first_page>37</first_page>
            <cYear>1960</cYear>
            <unstructured_citation>
                    Cohen J. 
                    The coefficient of agreement for nominal scales 
                    Educ Physiol Meas  
                    1960; 
                    20
                    : 37-46.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR24">
            <journal_title>Biometrics</journal_title>
            <author>Landis JR</author>
            <volume>33</volume>
            <first_page>159</first_page>
            <cYear>1977</cYear>
            <unstructured_citation>
                    Landis JR, Koch GG. 
                    The measurement of observer agreement on categorical data 
                    Biometrics  
                    1977; 
                    33
                    : 159-74.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR25">
            <journal_title>Science</journal_title>
            <author>Cameron JR</author>
            <volume>142</volume>
            <first_page>230</first_page>
            <cYear>1963</cYear>
            <unstructured_citation>
                    Cameron JR, Sorenson J. 
                    Measurement of bone mineral in vivo. An improved method 
                    Science  
                    1963; 
                    142
                    : 230.
                </unstructured_citation>
          </citation>
          <citation key="refR26">
            <journal_title>CRC Crit Rev Clin Lab Sci</journal_title>
            <author>Wahner HW</author>
            <volume>24</volume>
            <first_page>217</first_page>
            <cYear>1986</cYear>
            <unstructured_citation>
                    Wahner HW, Riggs BL. 
                    Method and application of bone densitometer in clinical diagnosis 
                    CRC Crit Rev Clin Lab Sci  
                    1986; 
                    24
                    : 217-33.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR27">
            <journal_title>S Afr Med J</journal_title>
            <author>Grobler SR</author>
            <volume>73</volume>
            <first_page>217</first_page>
            <cYear>1988</cYear>
            <unstructured_citation>
                    Grobler SR, Dreyer AG. 
                    Variations in the fluoride levels of drinking water in South Africa 
                    S Afr Med J  
                    1988; 
                    73
                    : 217-19.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR28">
            <unstructured_citation>
                    Mellberg JR, Ripa LW. 
                    Fluoride in Preventive Dentistry. 
                    Chicago: Quintessence Publishing 1983.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR29">
            <journal_title>Commun Dent Oral Epidemiol</journal_title>
            <author>El-Nadeef MAI</author>
            <volume>26</volume>
            <first_page>26</first_page>
            <cYear>1998</cYear>
            <unstructured_citation>
                    El-Nadeef MAI, Honkala E. 
                    Fluorosis in relation to fluoride levels in water in central Nigeria 
                    Commun Dent Oral Epidemiol  
                    1998; 
                    26
                    : 26-30.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR30">
            <journal_title>Commun Dent Oral Epidemiol</journal_title>
            <author>Olsson B</author>
            <volume>7</volume>
            <first_page>51</first_page>
            <cYear>1979</cYear>
            <unstructured_citation>
                    Olsson B. 
                    Dental findings in high fluoride areas in Ethiopia 
                    Commun Dent Oral Epidemiol  
                    1979; 
                    7
                    : 51-6.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR31">
            <unstructured_citation>
                    Carrie-Fassler AL, Bonjour JP. 
                    
                    Osteoporosis as a pediatric problem In: Gaul GE, Ed. 
                    Pediatr Clin North Am.  
                     1995; 42: pp. 
                    
                    811-24.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR32">
            <journal_title>J Bone Miner Res</journal_title>
            <author>Li Y</author>
            <volume>16</volume>
            <first_page>932</first_page>
            <cYear>2001</cYear>
            <unstructured_citation>
                    Li Y, Liang C, Slemenda CW, et al. 
                    Effect of long-term exposure to fluoride in drinking water on risks of bone fractures 
                    J Bone Miner Res  
                    2001; 
                    16
                    : 932-39.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR33">
            <journal_title>Fluoride</journal_title>
            <author>Czarnowski W</author>
            <volume>32</volume>
            <first_page>91</first_page>
            <cYear>1999</cYear>
            <unstructured_citation>
                    Czarnowski W, Krechniak J, Urbanska B, Stolarska K. 
                    The impact of water-borne fluoride on bone density 
                    Fluoride  
                    1999; 
                    32
                    : 91-5.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR34">
            <journal_title>Can J Public Health</journal_title>
            <author>Arnold CM</author>
            <volume>88</volume>
            <first_page>388</first_page>
            <cYear>1997</cYear>
            <unstructured_citation>
                    Arnold CM, Bailey DA, Faulkner RA, McKay HA, McCulloch RG. 
                    The effect of water fluoridation on the bone mineral density of young women 
                    Can J Public Health  
                    1997; 
                    88
                    : 388-91.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR35">
            <journal_title>Int J Epidemiol</journal_title>
            <author>Lan CF</author>
            <volume>24</volume>
            <first_page>1182</first_page>
            <cYear>1995</cYear>
            <unstructured_citation>
                    Lan CF, Lin IF, Wang SJ. 
                    Fluoride in the drinking water and the bone mineral density of women in Taiwan 
                    Int J Epidemiol  
                    1995; 
                    24
                    : 1182-7.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR36">
            <journal_title>Acta Paediatr</journal_title>
            <author>Bratteb LE</author>
            <volume>91</volume>
            <first_page>1031</first_page>
            <cYear>2002</cYear>
            <unstructured_citation>
                    Bratteb LE, Samuelson G, Sandhagen B, et al. 
                    Whole-body mineral measurements in Swedish adolescents at 17 years compared to 15 years of age 
                    Acta Paediatr  
                    2002; 
                    91
                    : 1031-8.
                    
                </unstructured_citation>
          </citation>
        </citation_list>
      </journal_article>
    </journal>
  </body>
</doi_batch>
