TODENTJ-25-03-2019_TODENTJ-2-78 1553504997 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 6 09 2008 2 1 Shuri Ohkura-Hada Nobuo Kondoh Akiyuki Hada Masaaki Arai Yutaka Yamazaki Masanobu Shindoh Yoshimasa Kitagawa Masayuki Takahashi Toshifumi Ando Yasunori Sato Mikio Yamamoto The molecular mechanisms of growth suppression by retinoic acid (RA) were examined. Our results suggest that the cytostatic effects of RA could be mediated by the activation of endogenous CBR3 gene in oral squamous cell carcinomas (OSCCs), and the expression is a potential marker for oral malignancy. 6 09 2008 78 88 TODENTJ-2-78 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2008-2-19 2008-3-19 2008-5-9 2008-6-09 http://creativecommons.org/licenses/by/2.5/ 10.2174/1874210600802010078 1553504997 https://opendentistryjournal.com/VOLUME/2/PAGE/78/ https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-78/TODENTJ-2-78.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-78/TODENTJ-2-78.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-78/TODENTJ-2-78.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-78/TODENTJ-2-78.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-78/TODENTJ-2-78.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-78/TODENTJ-2-78.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-78/TODENTJ-2-78.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-78/TODENTJ-2-78.xml FASEB J De Luca LM 5 2924 1991 De Luca LM. Retinoids and their receptors in differentiation embryogenesis and neoplasia FASEB J 1991; 5 (14) : 2924-33. FASEB J Lotan R 10 1031 1996 Lotan R. Retinoids in cancer chemoprevention FASEB J 1996; 10 (9) : 1031-9. Nat Med Altucci L 7 680 2001 Altucci L, Rossin A, Raffelsberger W, Reitmair A, Chomienne C, Gronemeyer H. Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL Nat Med 2001; 7 (6) : 680-6. Curr Pharm Des Garattini E 13 1375 2007 Garattini E, Gianni M, Terao M. Retinoids as differentiating agents in oncology a network of interactions with intracellular pathways as the basis for rational therapeutic combinations Curr Pharm Des 2007; 13 (13) : 1375-400. Br J Haematol Koistinen P 118 401 2002 Koistinen P, Zheng A, Saily M, Siitonen T, Mantymaa P, Savolainen ER. Superior effect of 9-cis retinoic acid (RA) compared with all-trans RA and 13-cis RA on the inhibition of clonogenic cell growth and the induction of apoptosis in OCI/AML-2 subclones is the p53 pathway involved? Br J Haematol 2002; 118 (2) : 401-10. Br J Cancer Ponthan F 85 2004 2001 Ponthan F, Kogner P, Bjellerup P, Klevenvall L, Hassan M. Bioavailability and dose-dependent anti-tumour effects of 9-cis retinoic acid on human neuroblastoma xenografts in rat Br J Cancer 2001; 85 (12) : 2004-9. Exp Cell Res Paik J 303 183 2005 Paik J, Blaner WS, Swisshelm K. Cis-retinol dehydrogenase 9-cis-retinol metabolism and its effect on proliferation of human MCF7 breast cancer cells Exp Cell Res 2005; 303 (1) : 183-96. Int J Oncol Tsujie M 23 325 2003 Tsujie M, Nakamori S, Okami J, et al. Growth inhibition of pancreatic cancer cells through activation of peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway Int J Oncol 2003; 23 (2) : 325-31. Am J Vet Res Hong SH 61 1241 2000 Hong SH, Kadosawa T, Mochizuki M, Matsunaga S, Nishimura R, Sasaki N. Effect of all-trans and 9-cis retinoic acid on growth and metastasis of xenotransplanted canine osteosarcoma cells in athymic mice Am J Vet Res 2000; 61 (10) : 1241-4. Cancer Lett Kanekura T 161 177 2000 Kanekura T, Higashi Y, Kanzaki T. Inhibitory effects of 9-cis-retinoic acid and pyrrolidinedithiocarbamate on cyclooxygenase (COX)-2 expression and cell growth in human skin squamous carcinoma cells Cancer Lett 2000; 161 (2) : 177-83. J Cardiovasc Pharmacol Johst U 41 526 2003 Johst U, Betsch A, Wiskirchen J, et al. All-trans and 9-cis retinoid acids inhibit proliferation migration and synthesis of extracellular matrix of human vascular smooth muscle cells by inducing differentiation in vitro J Cardiovasc Pharmacol 2003; 41 (4) : 526-35. J Biol Chem Tanaka T 282 29987 2007 Tanaka T, Suh KS, Lo AM, De Luca LM. p21WAF1/CIP1 is a common transcriptional target of retinoid receptors pleiotropic regulatory mechanism through retinoic acid receptor (RAR)/retinoid X receptor (RXR) heterodimer and RXR/RXR homodimer J Biol Chem 2007; 282 (41) : 29987-97. Cancer Res Borriello A 66 4240 2006 Borriello A, Cucciolla V, Criscuolo M, et al. Retinoic acid induces p27Kip1 nuclear accumulation by modulating its phosphorylation Cancer Res 2006; 66 (8) : 4240-8. Gastroenterology Wang J 130 747 2006 Wang J, Peng Y, Sun YW, et al. All-trans retinoic acid induces XAF1 expression through an interferon regulatory factor-1 element in colon cancer Gastroenterology 2006; 130 (3) : 747-58. Oncogene Afonja O 21 7850 2002 Afonja O, Raaka BM, Huang A, et al. RAR agonists stimulate SOX9 gene expression in breast cancer cell lines evidence for a role in retinoid-mediated growth inhibition Oncogene 2002; 21 (51) : 7850-60. Br J Cancer Umemoto M 85 1032 2001 Umemoto M, Yokoyama Y, Sato S, Tsuchida S, Al-Mulla F, Saito Y. Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer Br J Cancer 2001; 85 (7) : 1032-6. Cancer Epidemiol Biomarkers Prev Takenaka K 14 1972 2005 Takenaka K, Ogawa E, Oyanagi H, Wada H, Tanaka F. Carbonyl reductase expression and its clinical significance in non-small-cell lung cancer Cancer Epidemiol Biomarkers Prev 2005; 14 (8) : 1972-5. Cancer Res Ismail E 60 1173 2000 Ismail E, Al-Mulla F, Tsuchida S, et al. Carbonyl reductase: a novel metastasis-modulating function Cancer Res 2000; 60 (5) : 1173-6. Chem Biol Interact Terada T 143-144 373 2003 Terada T, Sugihara Y, Nakamura K, Mizobuchi H, Maeda M. Further characterization of Chinese hamster carbonyl reductases (CHCRs) Chem Biol Interact 2003; 143-144 : 373-81. J Biol Chem Wermuth B 263 16185 1988 Wermuth B, Bohren KM, Heinemann G, Von Warthburg PJ, Gabbay KH. Human carbonyl reductase. Nucreotide sequence analysis of cDNA and amino acid sequence of the encoded protein J Biol Chem 1988; 263 : 16185-8. J Biol Chem Wermuth B 256 1206 1981 Wermuth B. Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostagrandin 9-ketoreductase and xenobiotic ketone reductase J Biol Chem 1981; 256 : 1206-13. J Biochem Iwata N 107 209 1990 Iwata N, Inazu N, Satoh T. Immunological and enzymological locarization of carbonyl reductase in ovary and liver of various species J Biochem 1990; 107 : 209-12. Biochem Pharmacol Wermuth B 35 1277 1986 Wermuth B, Platts KL, Seidel A, Oesch F. Carbonyl reductase provides the enzymatic basis of quinone detoxication in man Biochem Pharmacol 1986; 35 (8) : 1277-82. J Clin Invest Harada S 93 2490 1994 Harada S, Nagy JA, Sullivan KA, et al. Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts J Clin Invest 1994; 93 (6) : 2490-6. Eur J Cancer Pace E 42 2382 2006 Pace E, Siena L, Ferraro M, et al. Role of prostaglandin E2 in the invasiveness, growth and protection of cancer cells in malignant pleuritis Eur J Cancer 2006; 42 (14) : 2382-9. Horm Metab Res Kozawa O 26 374 1994 Kozawa O, Suzuki A, Tokuda H, Kotoyori J, Ito Y, Oiso Y. Effect of retinoic acid on prostaglandin F2 alpha-induced prostaglandin E2 synthesis in osteoblast-like cells Horm Metab Res 1994; 26 (8) : 374-8. Cancer Yamamoto E 51 2175 1983 Yamamoto E, Kohama G, Sunakawa H, Iwai M, Hiratsuka H. Mode of invasion, bleomycin sensitivity, and clinical course in squamous cell carcinoma of the oral cavity Cancer 1983; 51 (12) : 2175-80.