TODENTJ-25-03-2019_TODENTJ-2-73 1553504995 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 6 3 2008 2 1 Alessandro Lanza Luigi Laino Luigi Rossiello Letizia Perillo Antonio Dell Ermo Nicola Cirillo A wide range of diseases may present with radiographic features of osteolysis. Periapical inflammation, cysts and benign tumours, bone malignancies, all of these conditions may show bone resorption on radiograph. Features of the surrounding bone, margins of the lesion, and biological behaviour including tendency to infiltration and root resorption, may represent important criteria for distinguishing benign tumours from their malign counterpart, although the radiographic aspect of the lesion is not always predictive. Therefore a critical differential diagnosis has to be reached to choose the best management. Here, we report a case of giant cell tumour (GCT) whose radiological features by computed tomography (CT) suggested the presence of bone malignancy, whereas the evaluation of a routine OPT scan comforted us about the benign nature of the lesion. A brief review of the literature on such a benign but locally aggressive neoplasm is also provided. 6 3 2008 73 77 TODENTJ-2-73 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2007-12-7 2007-12-19 2008-5-2 2008-6-3 http://creativecommons.org/licenses/by/2.5/ 10.2174/1874210600802010073 1553504995 https://opendentistryjournal.com/VOLUME/2/PAGE/73/ https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-73/TODENTJ-2-73.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-73/TODENTJ-2-73.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-73/TODENTJ-2-73.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-73/TODENTJ-2-73.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-73/TODENTJ-2-73.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-73/TODENTJ-2-73.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-73/TODENTJ-2-73.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-73/TODENTJ-2-73.xml Cytopathology Vargas PA 18 361 2007 Vargas PA, da Cruz Perez DE, Mata GM, de Almeida OP, Jones AV, Gerhard R. Fine needle aspiration cytology as an additional tool in the diagnosis of odontogenic keratocyst Cytopathology 2007; 18 : 361-6. Cytopathology Firat P 18 184 2007 Firat P, Ersoz C, Uguz A, Onder S. Cystic lesions of the head and neck: cytohistological correlation in 63 cases Cytopathology 2007; 18 : 184-90. J Oral Maxillofac Surg Nakamura S 63 989 2005 Nakamura S, Bessho K, Nakao K, Iizuka T, Scott RF. Langerhans' cell histiocytosis confined to the jaw J Oral Maxillofac Surg 2005; 63 : 989-5. Oral Oncol Shear M 38 219 2002 Shear M. The aggressive nature of the odontogenic keratocyst is it a benign cystic neoplasm?. Part 1. Clinical and early experimental evidence of aggressive behaviour Oral Oncol 2002; 38 : 219-6. Am J Clin Oncol Mendenhall WM 29 96 2006 Mendenhall WM, Zlotecki RA, Scarborough MT, Gibbs CP, Mendenhall NP. Giant cell tumor of bone Am J Clin Oncol 2006; 29 : 96-. Singapore Med J Faisham WI 47 679 2006 Faisham WI, Zulmi W, Halim AS, Biswal BM, Mutum SS, Ezane AM. Aggressive giant cell tumour of bone Singapore Med J 2006; 47 : 679-83. Oral Oncol Tobón-Arroyave SI 41 480 2005 Tobón-Arroyave SI, Franco-González LM, Isaza-Guzmán DM, Floréz-Moreno GA, Bravo-Vásquez T, Castañeda-Peláez DA. Vieco-Durán.Immunohistochemical expression of RANK GRalpha and CTR in central giant cell granuloma of the jaws Oral Oncol 2005; 41 : 480-8. Diagn Cytopathol Cai G 35 358 2007 Cai G, Ramdall R, Garcia R, Levine P. Pulmonary metastasis of giant cell tumor of the bone diagnosed by fine-needle aspiration biopsy Diagn Cytopathol 2007; 35 : 358-62. Neurosurgery Hunter CL 59 e1142 2006 Hunter CL, Pacione D, Hornyak M, Murali R. Giant-cell tumors of the cervical spine: case report Neurosurgery 2006; 59 : e1142-3. Minerva Stomatol Cicconetti A 48 553 1999 Cicconetti A, Matteini C, Piro FR. Differential diagnosis in a case of brown tumor caused by primary hyperparathyroidism Minerva Stomatol 1999; 48 : 553-8. Oncol Rep Wang C 15 589 2006 Wang C, Song Y, Peng B, et al. Expression of c-Src and comparison of cytologic features in cherubism, central giant cell granuloma and giant cell tumors Oncol Rep 2006; 15 : 589-94. J Craniofac Surg Schultze-Mosgau S 14 201 2003 Schultze-Mosgau S, Holbach LM, Wiltfang J. Cherubism clinical evidence and therapy J Craniofac Surg 2003; 14 : 201-6. Int J Pediatr Otorhinolaryngol Ustundag E 65 143 2002 Ustundag E, Iseri M, Keskin G, Muezzinoglu B. Central giant cell granuloma Int J Pediatr Otorhinolaryngol 2002; 65 : 143-6. Acta Otorhinolaryngol Ital Ciorba A 24 26 2004 Ciorba A, Altissimi G, Giansanti M. Giant cell granuloma of the maxilla case report Acta Otorhinolaryngol Ital 2004; 24 : 26-9. Am J Otolaryngol Keyser JS 17 407 1996 Keyser JS, Postma GN. Brown tumor of the mandible Am J Otolaryngol 1996; 17 : 407-10. Ear Nose Throat J Lessa MM 84 432 2005 Lessa MM, Sakae FA, Tsuji RK, Filho BC, Voegels RL, Butugan O. Brown tumor of the facial bones case report and literature review Ear Nose Throat J 2005; 84 : 432-. Med Oral Patol Oral Cir Bucal López-Arcas Calleja JM 12 e401 2007 López-Arcas Calleja JM, Cebrián Carretero JL, González Martín J, Burgueño M. Aneurysmal bone cyst of the mandible case presentation and review of the literature Med Oral Patol Oral Cir Bucal 2007; 12 : e401-3. Mod Pathol Regezi JA 15 331 2002 Regezi JA. Odontogenic cysts odontogenic tumors fibroosseous and giant cell lesions of the jaws Mod Pathol 2002; 15 : 331-41. Br J Oral Maxillofac Surg Uçkan S 37 152 1999 Uçkan S, Gürol M, Mutlu N, Güngör S. Non-ossifying fibroma of the mandible: report of a case Br J Oral Maxillofac Surg 1999; 37 : 152-4. J Oral Pathol Med Slootweg PJ 18 128 1989 Slootweg PJ. Comparison of giant cell granuloma of the jaw and non-ossifying fibroma J Oral Pathol Med 1989; 18 : 128-32. J Oral Maxillofac Surg Nakayama E 63 311 2005 Nakayama E, Sugiura K, Kobayashi I, Oobu K, Ishibashi H, Kanda S. The association between the computed tomography findings, histologic features, and outcome of osteosarcoma of the jaw J Oral Maxillofac Surg 2005; 63 : 311-8. Oral Dis Nissanka EH 13 82 2007 Nissanka EH, Amaratunge EA, Tilakaratne WM. Clinicopathological analysis of osteosarcoma of jaw bones Oral Dis 2007; 13 : 82-7. J Egypt Natl Canc Inst Khalilel SA 16 145 2004 Khalilel SA, Younis A, Aziz SA, El Shahawy M. Surgical management for giant cell tumor of bones J Egypt Natl Canc Inst 2004; 16 : 145-52. Int J Radiat Oncol Biol Phys Caudell JJ 57 158 2003 Caudell JJ, Ballo MT, Zagars GK, et al. Radiotherapy in the management of giant cell tumor of bone Int J Radiat Oncol Biol Phys 2003; 57 : 158-65.