TODENTJ-25-03-2019_TODENTJ-2-18 1553504982 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 2 21 2008 2 1 J. Kreth D. Kim M. Nguyen G. Hsiao R. Mito M.K. Kang N. Chugal W. Shi Pulpal and periradicular diseases are primarily caused by bacterial invasion of the root canal system as a result of caries progression. The presence of residual bacteria at the time of root canal completion (obturation) is associated with significantly higher rate of treatment failure. Re-infection of obturated root canals can be potentially prevented by enhancing the antibacterial activities of root canal obturation materials. We evaluated, in an in vitro model, the antimicrobial efficacy of silver ions added to a common endodontic sealer. For that purpose we performed growth inhibition studies and bacterial viability tests. We measured the zone of inhibition, optical density and performed confocal laser scanning microscopy. Our results show that the silver ions enhance the antimicrobial activity of the root canal sealer against Streptococcus mutans. This study approach may hold promise for studying other biologically based therapies and therefore increasing the success rate of routine orthograde root canal treatment. 2 21 2008 18 23 TODENTJ-2-18 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2007-8-21 2008-1-10 2008-2-21 http://creativecommons.org/licenses/by/2.5/ 10.2174/1874210600802010018 1553504982 https://opendentistryjournal.com/VOLUME/2/PAGE/18/ https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-18/TODENTJ-2-18.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-18/TODENTJ-2-18.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-18/TODENTJ-2-18.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-18/TODENTJ-2-18.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-18/TODENTJ-2-18.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-18/TODENTJ-2-18.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-18/TODENTJ-2-18.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-18/TODENTJ-2-18.xml J South Calif Dent Assoc Kakehashi S 34 449 1966 Kakehashi S, Stanley HR, Fitzgerald RJ. 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