Mast Cells and Angiogenesis in Oral Malignant and Premalignant Lesions

TODENTJ-25-03-2019_TODENTJ-2-126 1553505019 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 11 28 2008 2 1 Mast Cells and Angiogenesis in Oral Malignant and Premalignant Lesions E.Z Michailidou A.K Markopoulos D.Z Antoniades Mast cell contribution to neoangiogenesis during tumorigenesis in oral squamous cell carcinoma is not determined yet. Objectives: To associate numerical mast cell density (MCD) to numerical microvessel density (MVD) during the progression of oral leukoplakia without dysplasia and leukoplakia with dysplasia to squamous cell carcinoma (OSCC). Materials and methods: MVD was analysed immunohistochemically (mouse monoclonal anti-human CD34) in 49 paraffin-embedded specimens, 35 OSCCs, 9 leukoplakias and 5 normal oral tissues. Toluidine blue counterstaining revealed mast cells. MCD and MVD were assessed at the same optical field. Results: MVD increased between: normal oral mucosa, dysplasia (p=0.004), OSCC (p=0.001), leukoplakia and OSCC (p=0.041). MCD increased between: normal oral mucosa, dysplasia (p=0.003), OSCC (p=0.000), leukoplakia and OSCC (p=0.007). MVD was found to depend on MCD (p=0.000) in a percent 28.3% (power curve fit model). Conclusions: Mast cells are attracted at the lesion site and may turn on an angiogenic switch during tumorigenesis in OSCC. 11 28 2008 126 132 TODENTJ-2-126 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2008-3-31 2008-8-8 2008-10-24 2008-11-28 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210600802010126 1553505019 https://opendentistryjournal.com/VOLUME/2/PAGE/126/ https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-126/TODENTJ-2-126.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-126/TODENTJ-2-126.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-126/TODENTJ-2-126.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-126/TODENTJ-2-126.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-126/TODENTJ-2-126.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-126/TODENTJ-2-126.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-126/TODENTJ-2-126.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-126/TODENTJ-2-126.xml Physiol Rev Metcalfe DD 77 1033 1997 Metcalfe DD, Baram D, Mekori YA. 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