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        <full_title>The Open Dentistry Journal</full_title>
        <abbrev_title>TODENTJ</abbrev_title>
        <issn media_type="print">1874-2106</issn>
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          <month>11</month>
          <day>28</day>
          <year>2008</year>
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          <volume>2</volume>
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        <issue>1</issue>
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        <titles>
          <title>Microleakage and Resin-to-Dentin Interface Morphology of Pre-Etching versus Self-Etching Adhesive Systems</title>
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        <contributors>
          <person_name contributor_role="author" sequence="first">
            <given_name>G.L</given_name>
            <surname>Waldman</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>T.K</given_name>
            <surname>Vaidyanathan</surname>
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          <person_name contributor_role="author" sequence="additional">
            <given_name>J</given_name>
            <surname>Vaidyanathan</surname>
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                <jats:p>The purpose of this study was to compare the microleakage and tissue-adhesive interface morphology from Class V restorations using different systems of dentin adhesives. Class V cavities were prepared on buccal surfaces of 27 extracted caries-free molars and premolars. Teeth were randomly assigned to one of three groups: (1) Prime &amp; Bond NT, a 5<jats:sup>th</jats:sup> generation system using an initial step of total etch followed by a second step of application of a self bonding primer (2) Clearfil SE Bond, a 5<jats:sup>th</jats:sup> generation adhesive system employing two separate steps of self-etch priming and subsequent bonding (3) One-up Bond F, a 6<jats:sup>th</jats:sup> generation one step self-etching, self-priming and self-bonding adhesive. Microleakage and interface morphology of teeth restored with these adhesives and a composite resin were evaluated. Kruskal-Wallis Test (p = 0.05) was used to analyze the results. SEM analysis was used to relate interface morphology to microleakage. The mean and (SD) values of microleakage were: Prime and Bond NT: 0.15 (0.33), Clearfil SE Bond: 0.06 (0.17) and One-up Bond F: 2.96 (0.63). The mean microleakage for One-up Bond was significantly higher than for the other groups (p&lt;0.05). Protruding tags in dentin channels were observed in Prime and Bond and Clearfil systems, but not in One-up Bond. The single step adhesive system, although more convenient for the clinician, uses a low viscosity formulation difficult to keep in place on cavity walls. It also tends to be too aggressive and hydrophilic to create an impermeable hybridized tissue-adhesive interfacial layer resistant to microleakage. Two-step adhesive systems, on the other hand, were retained on all segments of the cavosurface during application, and formed a hybridized interfacial layer resistant to microleakage.</jats:p>
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