TODENTJ-25-03-2019_TODENTJ-2-1 1553505028 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 1 8 2008 2 1 N Elguezabal J.L. Maza S. Dorronsoro J. Pontón Adhesion of Candida albicans to acrylic of dental prostheses or to salivary macromolecules adsorbed on their surface is believed to be a critical event in the development of denture stomatitis. In previous studies our group has shown that adhesion of C. albicans germ tubes to polystyrene is decreased by saliva whereas C. albicans yeast cells adhesion to the same material is enhanced. The results presented in this study confirm this dual role played by whole saliva, since it decreased the adhesion of germ tubes but increased the adhesion of yeast cells to polymethylmetacrylate (PMMA). These effects mediated by whole saliva do not seem to be related to an inhibition of the germination of C. albicans, since similar levels of filamentation were observed in presence and absence of saliva. These results may give new insights into the conflicting role of saliva in the adhesion of C. albicans to acrylic resins of dental prostheses. 1 8 2008 1 4 TODENTJ-2-1 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2007-11-21 2007-12-12 2008-1-8 http://creativecommons.org/licenses/by/2.5/ 10.2174/1874210600802010001 1553505028 https://opendentistryjournal.com/VOLUME/2/PAGE/1/ https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-1/TODENTJ-2-1.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-1/TODENTJ-2-1.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-1/TODENTJ-2-1.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-1/TODENTJ-2-1.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-1/TODENTJ-2-1.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-1/TODENTJ-2-1.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-1/TODENTJ-2-1.pdf https://opendentistryjournal.com/contents/volumes/V2/TODENTJ-2-1/TODENTJ-2-1.xml Rev Iberoam Micol Aguirre JM 19 17 2002 Aguirre JM. Candidiasis orales Rev Iberoam Micol 2002; 19 : 17-21. Acta Odontol Scand Budtz-Jörgensen E 48 61 1990 Budtz-Jörgensen E. Etiology, pathogenesis, therapy and prophylaxis of oral yeast infections Acta Odontol Scand 1990; 48 : 61-9. Scand J Dent Res Budtz-Jörgensen E 82 151 1974 Budtz-Jörgensen E. The significance of Candida albicans in denture stomatitis Scand J Dent Res 1974; 82 : 151-90. Arch Oral Biol Vasilas A 37 613 1992 Vasilas A, Molina L, Hoffman M, Haidaris C. The influence of morphological variation on Candida albicans adhesion to denture acrylic in vitro Arch Oral Biol 1992; 37 : 613-22. Trends Microbiol Douglas LJ 11 30 2003 Douglas LJ. Candida biofilms and their role in infection Trends Microbiol 2003; 11 : 30-6. Microbiol Mol Bio Rev Marcotte H 62 71 1998 Marcotte H, Lavoie MC. Oral microbial ecology and the role of salivary immunoglobulin A Microbiol Mol Bio Rev 1998; 62 : 71-109. J Med Microbiol McCourtie J 21 209 1986 McCourtie J, MacFarlane T, Samaranayake L. Effect of saliva and serum on the adherence of Candida spp to clorhexidine-treated denture acrylic J Med Microbiol 1986; 21 : 209-13. Arch Oral Biol Samaranayake LP 25 1980 Samaranayake LP, McCourtie J, MacFarlane TW. Factors affecting the in vitro adherence of Candida albicans to acrylic surfaces Arch Oral Biol 1980; 25 Microbiology San Millán R 146 2105 2000 San Millán R, Elguezabal N, Regúlez P, Moragues MD, Quindós G, Pontón J. Effect of salivary secretory IgA on the adhesion of Candida albicans to polysterene Microbiology 2000; 146 : 2105-12. Oral Dis Elguezabal N 10 81 2004 Elguezabal N, Maza JL, Pontón J. Inhibition of adherence of Candida albicans and Candida dubliniensis to a resin composite restorative dental material by salivary secretory IgA and monoclonal antibodies Oral Dis 2004; 10 : 81-6. Oral Surg Oral Med Oral Pathol Maza JL 94 589 2002 Maza JL, Elguezabal N, Prado C, Ellacuría J, Soler I, Pontón J. Candida albicans adherence to resin-composite restorative dental material: Influence of whole human saliva Oral Surg Oral Med Oral Pathol 2002; 94 : 589-92. J Prosthet Dent Silva Moura J 96 205 2006 Silva Moura J, da Silva WJ, Pereira T, Del Bel Curry AA, Rodrigues-Garcia RC. Influence of acrylic resin polymerization methods and saliva on the adherence of four Candida species J Prosthet Dent 2006; 96 : 205-11. J Mater Sci Mater Med Epub ahead of print Karaagaclioglu L 2007 Aug1 Karaagaclioglu L, Gulsen C, Yilmaz B, Ayham N, Semiz O, Levent H. The adherence of Candida albicans to acrylic resin reinforced with different fibers J Mater Sci Mater Med Epub ahead of print Aug1; 2007 J Clin Microbiol Umazume M 33 432 1995 Umazume M, Ueta E, Osaki T. Reduced inhibition of Candida albicans adhesion by saliva from patients receiving oral cancer therapy J Clin Microbiol 1995; 33 : 432-9. Infect Immun Edgerton M 61 2644 1993 Edgerton M, Scannapieco F, Reddy M, Levine M. Human submandibular-sublingual saliva promotes adhesion of Candida albicans to polymethylmethacrylate Infect Immun 1993; 61 : 2644-52. J Dent Res Holmes AR 81 28 2002 Holmes AR, Bandara BMK, Cannon RD. Saliva promotes Candida albicans adherence to human epithelial cells J Dent Res 2002; 81 : 28-32. Arch Oral Biol Samaranayake LP 25 603 1980 Samaranayake LP, MacFarlane TW. An in vitro study of the adherence of Candida albicans to acrylic surfaces Arch Oral Biol 1980; 25 : 603-9. Infect Immun Tronchin G 56 1987 1988 Tronchin G, Bouchara JP, Robert R, Senet JM. Adherence of Candida albicans germ tube to plastic: ultrastructural and molecular studies of fibrillar adhesins Infect Immun 1988; 56 : 1987-93. Microbiology San Millán R 142 2271 1996 San Millán R, Ezkurra PA, Quindós G, Robert R, Senet JM, Pontón J. Effect of monoclonal antibodies directed against Candida albicans cell wall antigens on the adhesion of the fungus to polystyrene Microbiology 1996; 142 : 2271-7. Infect Immun Hoffman MP 61 1940 1993 Hoffman MP, Haidaris CG. Analysis of Candida albicans adhesion to salivary mucin Infect Immun 1993; 61 : 1940-9. J Oral Pathol Tabak LA 11 1 1982 Tabak LA, Levine MJ, Mandel ID, Ellison SA. Role of salivary mucin in protection of the oral cavity J Oral Pathol 1982; 11 : 1-7. Antimicrob Agents Chemother Fitzgerald DH 47 70 2003 Fitzgerald DH, Coleman DC, O´Connell BC. Susceptibility of Candida dubliniensis to salivary histatin 3 Antimicrob Agents Chemother 2003; 47 : 70-6. J Biol Chem Oppenheim FG 263 7472 1988 Oppenheim FG, Xu T, McMillan FM, et al. Histatins, a novel family of histidine-rich proteins in human parotid secretions J Biol Chem 1988; 263 : 7472-7. Infect Immun Kimura LH 28 464 1980 Kimura LH, Pearsall NN. Relationship between germination of Candida albicans and increased adherence to human buccal epithelial cells Infect Immun 1980; 28 : 464-8. J Oral Pathol Med Manfredi M 36 468 2007 Manfredi M, Merigo E, Salati A, et al. In vitro candidacidal activity of a synthetic killer decapeptide (KP) against Candida albicans cells adhered to resin acrylic discs J Oral Pathol Med 2007; 36 : 468-71.