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        <full_title>The Open Dentistry Journal</full_title>
        <abbrev_title>TODENTJ</abbrev_title>
        <issn media_type="print">1874-2106</issn>
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      <journal_issue>
        <publication_date media_type="print">
          <month>10</month>
          <day>30</day>
          <year>2018</year>
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        <journal_volume>
          <volume>12</volume>
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        <issue>1</issue>
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      <journal_article publication_type="full_text">
        <titles>
          <title>Alveolar Ridge Preservation: A Histomorphometric Analysis</title>
        </titles>
        <contributors>
          <person_name contributor_role="author" sequence="first">
            <given_name>Sigmar</given_name>
            <surname>Schnutenhaus</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Werner</given_name>
            <surname>Götz</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Jens</given_name>
            <surname>Dreyhaupt</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Heike</given_name>
            <surname>Rudolph</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Ralph G.</given_name>
            <surname>Luthardt</surname>
          </person_name>
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                <jats:sec>
                    <jats:title>Objective:</jats:title>
                    <jats:p>This study presents the histomorphometric findings after tooth extraction with and without Alveolar Ridge Preservation (ARP) with a collagen cone filling the socket in combination with a collagen membrane covering the socket.</jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Materials and Methods:</jats:title>
                    <jats:p>In a controlled randomized clinical study, 10 patients were treated with the combination material after tooth extraction. In 10 patients, the extraction sockets were left to heal without further intervention. Soft tissue, new bone formation, bone quality and bone remodeling, blood flow vascularization, and inflammation were evaluated histomorphometrically. This was performed (semi-) quantitatively using a blinded protocol.</jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Results:</jats:title>
                    <jats:p>The statistical evaluation showed no significant difference for any parameter. When the combination material was used, more pronounced remodeling, increased osteoblast activity, and increased vascularization were demonstrated based on the histomorphometric findings. In contrast, there were reduced levels of osteogenesis and less mineralization. There was slightly more bundle bone in patients with ARP.</jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Conclusion:</jats:title>
                    <jats:p>The histomorphometric analysis of ARP with a combination material consisting of a collagen cone and a collagen membrane showed no significant differences in terms of new bone formation and bone quality. Descriptively, however, different manifestations were seen that might benefit from being documented using larger samples and being tested for clinical relevance.</jats:p>
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            </jats:abstract>
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          <month>10</month>
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          <year>2018</year>
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        <citation_list>
          <citation key="ref1">
            <journal_title>Clin. Oral Implants Res.</journal_title>
            <author>Tan W.L.</author>
            <volume>23</volume>
            <first_page>1</first_page>
            <cYear>2012</cYear>
            <doi>10.1111/j.1600-0501.2011.02375.x</doi>
            <unstructured_citation>
                    Tan WL, Wong TL, Wong MC, Lang NP. 
                    A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. 
                    Clin Oral Implants Res  
                    2012; 
                    23
                    (Suppl. 5)
                    : 1-21.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref2">
            <journal_title>J. Clin. Periodontol.</journal_title>
            <author>Araújo M.G.</author>
            <volume>32</volume>
            <first_page>212</first_page>
            <cYear>2005</cYear>
            <doi>10.1111/j.1600-051X.2005.00642.x</doi>
            <unstructured_citation>
                    Araújo MG, Lindhe J. 
                    Dimensional ridge alterations following tooth extraction. An experimental study in the dog. 
                    J Clin Periodontol  
                    2005; 
                    32
                    (2)
                    : 212-8.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref3">
            <journal_title>J. Periodontol.</journal_title>
            <author>Evian C.I.</author>
            <volume>53</volume>
            <first_page>81</first_page>
            <cYear>1982</cYear>
            <doi>10.1902/jop.1982.53.2.81</doi>
            <unstructured_citation>
                    Evian CI, Rosenberg ES, Coslet JG, Corn H. 
                    The osteogenic activity of bone removed from healing extraction sockets in humans. 
                    J Periodontol  
                    1982; 
                    53
                    (2)
                    : 81-5.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref4">
            <journal_title>J. Clin. Periodontol.</journal_title>
            <author>Trombelli L.</author>
            <volume>35</volume>
            <first_page>630</first_page>
            <cYear>2008</cYear>
            <doi>10.1111/j.1600-051X.2008.01246.x</doi>
            <unstructured_citation>
                    Trombelli L, Farina R, Marzola A, Bozzi L, Liljenberg B, Lindhe J. 
                    Modeling and remodeling of human extraction sockets. 
                    J Clin Periodontol  
                    2008; 
                    35
                    (7)
                    : 630-9.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref5">
            <journal_title>Int. J. Dent.</journal_title>
            <author>Pagni G.</author>
            <volume>2012</volume>
            <first_page>151030</first_page>
            <cYear>2012</cYear>
            <doi>10.1155/2012/151030</doi>
            <unstructured_citation>
                    Pagni G, Pellegrini G, Giannobile WV, Rasperini G. 
                    Postextraction alveolar ridge preservation: biological basis and treatments. 
                    Int J Dent  
                    2012; 
                    2012
                    : 151030.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref6">
            <journal_title>J. Prosthodont. Res.</journal_title>
            <author>Masaki C.</author>
            <volume>59</volume>
            <first_page>220</first_page>
            <cYear>2015</cYear>
            <doi>10.1016/j.jpor.2015.04.005</doi>
            <unstructured_citation>
                    Masaki C, Nakamoto T, Mukaibo T, Kondo Y, Hosokawa R. 
                    Strategies for alveolar ridge reconstruction and preservation for implant therapy. 
                    J Prosthodont Res  
                    2015; 
                    59
                    (4)
                    : 220-8.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref7">
            <journal_title>J. Clin. Periodontol.</journal_title>
            <author>Flügge T.</author>
            <volume>42</volume>
            <first_page>390</first_page>
            <cYear>2015</cYear>
            <doi>10.1111/jcpe.12386</doi>
            <unstructured_citation>
                    Flügge T, Nelson K, Nack C, Stricker A, Nahles S. 
                    2-Dimensional changes of the soft tissue profile of augmented and non-augmented human extraction sockets: A randomized pilot study. 
                    J Clin Periodontol  
                    2015; 
                    42
                    (4)
                    : 390-7.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref8">
            <journal_title>Quintessence Int.</journal_title>
            <author>Oghli A.A.</author>
            <volume>41</volume>
            <first_page>605</first_page>
            <cYear>2010</cYear>
            <unstructured_citation>
                    Oghli AA, Steveling H. 
                    Ridge preservation following tooth extraction: A comparison between atraumatic extraction and socket seal surgery. 
                    Quintessence Int  
                    2010; 
                    41
                    (7)
                    : 605-9.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref9">
            <journal_title>Clin. Oral Implants Res.</journal_title>
            <author>Ten Heggeler J.M.</author>
            <volume>22</volume>
            <first_page>779</first_page>
            <cYear>2011</cYear>
            <doi>10.1111/j.1600-0501.2010.02064.x</doi>
            <unstructured_citation>
                    Ten Heggeler JM, Slot DE, Van der Weijden GA. 
                    Effect of socket preservation therapies following tooth extraction in non-molar regions in humans: A systematic review. 
                    Clin Oral Implants Res  
                    2011; 
                    22
                    (8)
                    : 779-88.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref10">
            <journal_title>J. Dent. Res.</journal_title>
            <author>Avila-Ortiz G.</author>
            <volume>93</volume>
            <first_page>950</first_page>
            <cYear>2014</cYear>
            <doi>10.1177/0022034514541127</doi>
            <unstructured_citation>
                    Avila-Ortiz G, Elangovan S, Kramer KW, Blanchette D, Dawson DV. 
                    Effect of alveolar ridge preservation after tooth extraction: A systematic review and meta-analysis. 
                    J Dent Res  
                    2014; 
                    93
                    (10)
                    : 950-8.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref11">
            <journal_title>J. Funct. Biomater.</journal_title>
            <author>Jamjoom A.</author>
            <volume>6</volume>
            <first_page>833</first_page>
            <cYear>2015</cYear>
            <doi>10.3390/jfb6030833</doi>
            <unstructured_citation>
                    Jamjoom A, Cohen RE. 
                    Grafts for ridge preservation. 
                    J Funct Biomater  
                    2015; 
                    6
                    (3)
                    : 833-48.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref12">
            <journal_title>Clin. Implant Dent. Relat. Res.</journal_title>
            <author>Morjaria K.R.</author>
            <volume>16</volume>
            <first_page>1</first_page>
            <cYear>2014</cYear>
            <doi>10.1111/j.1708-8208.2012.00450.x</doi>
            <unstructured_citation>
                    Morjaria KR, Wilson R, Palmer RM. 
                    Bone healing after tooth extraction with or without an intervention: A systematic review of randomized controlled trials. 
                    Clin Implant Dent Relat Res  
                    2014; 
                    16
                    (1)
                    : 1-20.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref13">
            <journal_title>Int. J. Periodontics Restorative Dent.</journal_title>
            <author>Avila-Ortiz G.</author>
            <volume>34</volume>
            <first_page>509</first_page>
            <cYear>2014</cYear>
            <doi>10.11607/prd.1838</doi>
            <unstructured_citation>
                    Avila-Ortiz G, Rodriguez JC, Rudek I, Benavides E, Rios H, Wang HL. 
                    Effectiveness of three different alveolar ridge preservation techniques: A pilot randomized controlled trial. 
                    Int J Periodontics Restorative Dent  
                    2014; 
                    34
                    (4)
                    : 509-21.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref14">
            <journal_title>J. Periodontol.</journal_title>
            <author>Becker W.</author>
            <volume>69</volume>
            <first_page>414</first_page>
            <cYear>1998</cYear>
            <doi>10.1902/jop.1998.69.4.414</doi>
            <unstructured_citation>
                    Becker W, Clokie C, Sennerby L, Urist MR, Becker BE. 
                    Histologic findings after implantation and evaluation of different grafting materials and titanium micro screws into extraction sockets: Case reports. 
                    J Periodontol  
                    1998; 
                    69
                    (4)
                    : 414-21.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref15">
            <journal_title>Int. J. Oral Maxillofac. Surg.</journal_title>
            <author>Checchi V.</author>
            <volume>40</volume>
            <first_page>526</first_page>
            <cYear>2011</cYear>
            <doi>10.1016/j.ijom.2010.12.005</doi>
            <unstructured_citation>
                    Checchi V, Savarino L, Montevecchi M, Felice P, Checchi L. 
                    Clinical-radiographic and histological evaluation of two hydroxyapatites in human extraction sockets: A pilot study. 
                    Int J Oral Maxillofac Surg  
                    2011; 
                    40
                    (5)
                    : 526-32.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref16">
            <journal_title>J. Periodontol.</journal_title>
            <author>Hoang T.N.</author>
            <volume>83</volume>
            <first_page>174</first_page>
            <cYear>2012</cYear>
            <doi>10.1902/jop.2011.110209</doi>
            <unstructured_citation>
                    Hoang TN, Mealey BL. 
                    Histologic comparison of healing after ridge preservation using human demineralized bone matrix putty with one versus two different-sized bone particles. 
                    J Periodontol  
                    2012; 
                    83
                    (2)
                    : 174-81.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref17">
            <journal_title>J. Periodontol.</journal_title>
            <author>Nam H.W.</author>
            <volume>82</volume>
            <first_page>471</first_page>
            <cYear>2011</cYear>
            <doi>10.1902/jop.2010.100193</doi>
            <unstructured_citation>
                    Nam HW, Park JB, Lee JY, et al. 
                    Enhanced ridge preservation by bone mineral bound with collagen-binding synthetic oligopeptide: A clinical and histologic study in humans. 
                    J Periodontol  
                    2011; 
                    82
                    (3)
                    : 471-80.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref18">
            <journal_title>Clin. Oral Implants Res.</journal_title>
            <author>Pelegrine A.A.</author>
            <volume>21</volume>
            <first_page>535</first_page>
            <cYear>2010</cYear>
            <doi>10.1111/j.1600-0501.2009.01891.x</doi>
            <unstructured_citation>
                    Pelegrine AA, da Costa CE, Correa ME, Marques JF Jr. 
                    Clinical and histomorphometric evaluation of extraction sockets treated with an autologous bone marrow graft. 
                    Clin Oral Implants Res  
                    2010; 
                    21
                    (5)
                    : 535-42.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref19">
            <journal_title>J. Periodontol.</journal_title>
            <author>Froum S.</author>
            <volume>73</volume>
            <first_page>94</first_page>
            <cYear>2002</cYear>
            <doi>10.1902/jop.2002.73.1.94</doi>
            <unstructured_citation>
                    Froum S, Cho SC, Rosenberg E, Rohrer M, Tarnow D. 
                    Histological comparison of healing extraction sockets implanted with bioactive glass or demineralized freeze-dried bone allograft: A pilot study. 
                    J Periodontol  
                    2002; 
                    73
                    (1)
                    : 94-102.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref20">
            <journal_title>J. Periodontol.</journal_title>
            <author>Wood R.A.</author>
            <volume>83</volume>
            <first_page>329</first_page>
            <cYear>2012</cYear>
            <doi>10.1902/jop.2011.110270</doi>
            <unstructured_citation>
                    Wood RA, Mealey BL. 
                    Histologic comparison of healing after tooth extraction with ridge preservation using mineralized versus demineralized freeze-dried bone allograft. 
                    J Periodontol  
                    2012; 
                    83
                    (3)
                    : 329-36.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref21">
            <journal_title>J. Periodontol.</journal_title>
            <author>Iasella J.M.</author>
            <volume>74</volume>
            <first_page>990</first_page>
            <cYear>2003</cYear>
            <doi>10.1902/jop.2003.74.7.990</doi>
            <unstructured_citation>
                    Iasella JM, Greenwell H, Miller RL, et al. 
                    Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: A clinical and histologic study in humans. 
                    J Periodontol  
                    2003; 
                    74
                    (7)
                    : 990-9.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref22">
            <journal_title>Int. J. Oral Maxillofac. Implants</journal_title>
            <author>Smukler H.</author>
            <volume>14</volume>
            <first_page>407</first_page>
            <cYear>1999</cYear>
            <unstructured_citation>
                    Smukler H, Landi L, Setayesh R. 
                    Histomorphometric evaluation of extraction sockets and deficient alveolar ridges treated with allograft and barrier membrane: A pilot study. 
                    Int J Oral Maxillofac Implants  
                    1999; 
                    14
                    (3)
                    : 407-16.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref23">
            <journal_title>J. Periodontol.</journal_title>
            <author>Barone A.</author>
            <volume>79</volume>
            <first_page>1370</first_page>
            <cYear>2008</cYear>
            <doi>10.1902/jop.2008.070628</doi>
            <unstructured_citation>
                    Barone A, Aldini NN, Fini M, Giardino R, Calvo Guirado JL, Covani U. 
                    Xenograft versus extraction alone for ridge preservation after tooth removal: A clinical and histomorphometric study. 
                    J Periodontol  
                    2008; 
                    79
                    (8)
                    : 1370-7.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref24">
            <journal_title>Int. J. Periodontics Restorative Dent.</journal_title>
            <author>Cardaropoli D.</author>
            <volume>32</volume>
            <first_page>421</first_page>
            <cYear>2012</cYear>
            <unstructured_citation>
                    Cardaropoli D, Tamagnone L, Roffredo A, Gaveglio L, Cardaropoli G. 
                    Socket preservation using bovine bone mineral and collagen membrane: A randomized controlled clinical trial with histologic analysis. 
                    Int J Periodontics Restorative Dent  
                    2012; 
                    32
                    (4)
                    : 421-30.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref25">
            <journal_title>J. Periodontol.</journal_title>
            <author>Fiorellini J.P.</author>
            <volume>76</volume>
            <first_page>605</first_page>
            <cYear>2005</cYear>
            <doi>10.1902/jop.2005.76.4.605</doi>
            <unstructured_citation>
                    Fiorellini JP, Howell TH, Cochran D, et al. 
                    Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation. 
                    J Periodontol  
                    2005; 
                    76
                    (4)
                    : 605-13.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref26">
            <journal_title>Mater. Sci. Eng. C</journal_title>
            <author>Kunert-Keil C.</author>
            <volume>46</volume>
            <first_page>177</first_page>
            <cYear>2015</cYear>
            <doi>10.1016/j.msec.2014.10.033</doi>
            <unstructured_citation>
                    Kunert-Keil C, Gredes T, Heinemann F, Dominiak M, Botzenhart U, Gedrange T. 
                    Socket augmentation using a commercial collagen-based product: An animal study in pigs. 
                    Mater Sci Eng C  
                    2015; 
                    46
                    : 177-83.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref27">
            <journal_title>Implantologie</journal_title>
            <author>Annen B.</author>
            <volume>22</volume>
            <first_page>341</first_page>
            <cYear>2014</cYear>
            <unstructured_citation>
                    Annen B, Schneider D, Schmidlin P. 
                    Kammerhalt nach zahnextraktion durch kolleagenkegel mit integrierter membran. Eine fallserie mit volumetrischer auswertung. 
                    Implantologie  
                    2014; 
                    22
                    : 341-51.
                    
                </unstructured_citation>
          </citation>
          <citation key="ref28">
            <journal_title>Int J Clin Res Trial</journal_title>
            <author>Schnutenhaus S.</author>
            <volume>2</volume>
            <first_page>116</first_page>
            <cYear>2017</cYear>
            <doi>10.15344/2456-8007/2017/116</doi>
            <unstructured_citation>
                    Schnutenhaus S, Dreyhaupt J, Doering I, Rudolph H, Luthardt RG. 
                    Alveolar ridge preservation as a way to reduce the need for bone augmentation: Implementation of a mew, non-invasive method of measuring bone preservation: Study protocol of a randomized controlled clinical trial and feasibility testing results. 
                    Int J Clin Res Trial  
                    2017; 
                    2
                    : 116.
                    
                </unstructured_citation>
          </citation>
          <citation key="ref29">
            <unstructured_citation>
                    Standardization. IIOf. ISO 10993-6.  
                    Biological evaluation of medical devices Part 6: Tests for local effects after implantation  Available from:  
                    2007.
                    www.iso.org/obp/ui/#iso:std:iso:10933:-6:ed-2:en
                </unstructured_citation>
          </citation>
          <citation key="ref30">
            <journal_title>Clin. Oral Implants Res.</journal_title>
            <author>Gholami G.A.</author>
            <volume>23</volume>
            <first_page>1198</first_page>
            <cYear>2012</cYear>
            <doi>10.1111/j.1600-0501.2011.02288.x</doi>
            <unstructured_citation>
                    Gholami GA, Najafi B, Mashhadiabbas F, Goetz W, Najafi S. 
                    Clinical, histologic and histomorphometric evaluation of socket preservation using a synthetic nanocrystalline hydroxyapatite in comparison with a bovine xenograft: A randomized clinical trial. 
                    Clin Oral Implants Res  
                    2012; 
                    23
                    (10)
                    : 1198-204.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref31">
            <journal_title>Int. J. Periodontics Restorative Dent.</journal_title>
            <author>Schropp L.</author>
            <volume>23</volume>
            <first_page>313</first_page>
            <cYear>2003</cYear>
            <unstructured_citation>
                    Schropp L, Wenzel A, Kostopoulos L, Karring T. 
                    Bone healing and soft tissue contour changes following single-tooth extraction: A clinical and radiographic 12-month prospective study. 
                    Int J Periodontics Restorative Dent  
                    2003; 
                    23
                    (4)
                    : 313-23.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref32">
            <journal_title>J. Clin. Periodontol.</journal_title>
            <author>Jung R.E.</author>
            <volume>40</volume>
            <first_page>90</first_page>
            <cYear>2013</cYear>
            <doi>10.1111/jcpe.12027</doi>
            <unstructured_citation>
                    Jung RE, Philipp A, Annen BM, et al. 
                    Radiographic evaluation of different techniques for ridge preservation after tooth extraction: A randomized controlled clinical trial. 
                    J Clin Periodontol  
                    2013; 
                    40
                    (1)
                    : 90-8.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref33">
            <journal_title>Implant Dent.</journal_title>
            <author>Kim Y.K.</author>
            <volume>20</volume>
            <first_page>267</first_page>
            <cYear>2011</cYear>
            <doi>10.1097/ID.0b013e3182166afc</doi>
            <unstructured_citation>
                    Kim YK, Yun PY, Lee HJ, Ahn JY, Kim SG. 
                    Ridge preservation of the molar extraction socket using collagen sponge and xenogeneic bone grafts. 
                    Implant Dent  
                    2011; 
                    20
                    (4)
                    : 267-72.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref34">
            <journal_title>J. Periodontol.</journal_title>
            <author>Engler-Hamm D.</author>
            <volume>82</volume>
            <first_page>377</first_page>
            <cYear>2011</cYear>
            <doi>10.1902/jop.2010.090342</doi>
            <unstructured_citation>
                    Engler-Hamm D, Cheung WS, Yen A, Stark PC, Griffin T. 
                    Ridge preservation using a composite bone graft and a bioabsorbable membrane with and without primary wound closure: A comparative clinical trial. 
                    J Periodontol  
                    2011; 
                    82
                    (3)
                    : 377-87.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref35">
            <journal_title>Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.</journal_title>
            <author>Kesmas S.</author>
            <volume>110</volume>
            <first_page>e24</first_page>
            <cYear>2010</cYear>
            <doi>10.1016/j.tripleo.2010.06.006</doi>
            <unstructured_citation>
                    Kesmas S, Swasdison S, Yodsanga S, Sessirisombat S, Jansisyanont P. 
                    Esthetic alveolar ridge preservation with calcium phosphate and collagen membrane: preliminary report. 
                    Oral Surg Oral Med Oral Pathol Oral Radiol Endod  
                    2010; 
                    110
                    (5)
                    : e24-36.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref36">
            <journal_title>Clin. Oral Implants Res.</journal_title>
            <author>Mardas N.</author>
            <volume>21</volume>
            <first_page>688</first_page>
            <cYear>2010</cYear>
            <doi>10.1111/j.1600-0501.2010.01918.x</doi>
            <unstructured_citation>
                    Mardas N, Chadha V, Donos N. 
                    Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: A randomized, controlled clinical trial. 
                    Clin Oral Implants Res  
                    2010; 
                    21
                    (7)
                    : 688-98.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref37">
            <journal_title>Int. J. Oral Maxillofac. Implants</journal_title>
            <author>Ahn J.J.</author>
            <volume>23</volume>
            <first_page>1133</first_page>
            <cYear>2008</cYear>
            <unstructured_citation>
                    Ahn JJ, Shin HI. 
                    Bone tissue formation in extraction sockets from sites with advanced periodontal disease: A histomorphometric study in humans. 
                    Int J Oral Maxillofac Implants  
                    2008; 
                    23
                    (6)
                    : 1133-8.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref38">
            <journal_title>Clin. Oral Implants Res.</journal_title>
            <author>Nahles S.</author>
            <volume>24</volume>
            <first_page>812</first_page>
            <cYear>2013</cYear>
            <doi>10.1111/j.1600-0501.2012.02462.x</doi>
            <unstructured_citation>
                    Nahles S, Nack C, Gratecap K, Lage H, Nelson JJ, Nelson K. 
                    Bone physiology in human grafted and non-grafted extraction sockets: An immunohistochemical study. 
                    Clin Oral Implants Res  
                    2013; 
                    24
                    (7)
                    : 812-9.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref39">
            <journal_title>J. Evid. Based Dent. Pract.</journal_title>
            <author>Horowitz R.</author>
            <volume>12</volume>
            <first_page>149</first_page>
            <cYear>2012</cYear>
            <doi>10.1016/S1532-3382(12)70029-5</doi>
            <unstructured_citation>
                    Horowitz R, Holtzclaw D, Rosen PS. 
                    A review on alveolar ridge preservation following tooth extraction. 
                    J Evid Based Dent Pract  
                    2012; 
                    12
                    (3)
                    (Suppl.)
                    : 149-60.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref40">
            <journal_title>Int. J. Periodontics Restorative Dent.</journal_title>
            <author>Perelman-Karmon M.</author>
            <volume>32</volume>
            <first_page>459</first_page>
            <cYear>2012</cYear>
            <unstructured_citation>
                    Perelman-Karmon M, Kozlovsky A, Liloy R, Artzi Z. 
                    Socket site preservation using bovine bone mineral with and without a bioresorbable collagen membrane. 
                    Int J Periodontics Restorative Dent  
                    2012; 
                    32
                    (4)
                    : 459-65.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref41">
            <journal_title>Clin. Oral Implants Res.</journal_title>
            <author>Caneva M.</author>
            <volume>21</volume>
            <first_page>891</first_page>
            <cYear>2010</cYear>
            <unstructured_citation>
                    Caneva M, Botticelli D, Salata LA, Scombatti Souza SL, Carvalho Cardoso L, Lang NP. 
                    Collagen membranes at immediate implants: A histomorphometric study in dogs. 
                    Clin Oral Implants Res  
                    2010; 
                    21
                    (9)
                    : 891-7.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref42">
            <journal_title>J. Periodontol.</journal_title>
            <author>Toloue S.M.</author>
            <volume>83</volume>
            <first_page>847</first_page>
            <cYear>2012</cYear>
            <doi>10.1902/jop.2011.110470</doi>
            <unstructured_citation>
                    Toloue SM, Chesnoiu-Matei I, Blanchard SB. 
                    A clinical and histomorphometric study of calcium sulfate compared with freeze-dried bone allograft for alveolar ridge preservation. 
                    J Periodontol  
                    2012; 
                    83
                    (7)
                    : 847-55.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref43">
            <journal_title>J. Periodontol.</journal_title>
            <author>Neiva R.F.</author>
            <volume>79</volume>
            <first_page>291</first_page>
            <cYear>2008</cYear>
            <doi>10.1902/jop.2008.070038</doi>
            <unstructured_citation>
                    Neiva RF, Tsao YP, Eber R, Shotwell J, Billy E, Wang HL. 
                    Effects of a putty-form hydroxyapatite matrix combined with the synthetic cell-binding peptide P-15 on alveolar ridge preservation. 
                    J Periodontol  
                    2008; 
                    79
                    (2)
                    : 291-9.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref44">
            <journal_title>J. Periodontol.</journal_title>
            <author>Poulias E.</author>
            <volume>84</volume>
            <first_page>1567</first_page>
            <cYear>2013</cYear>
            <unstructured_citation>
                    Poulias E, Greenwell H, Hill M, et al. 
                    Ridge preservation comparing socket allograft alone to socket allograft plus facial overlay xenograft: A clinical and histologic study in humans. 
                    J Periodontol  
                    2013; 
                    84
                    (11)
                    : 1567-75.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref45">
            <journal_title>J. Periodontol.</journal_title>
            <author>Borg T.D.</author>
            <volume>86</volume>
            <first_page>348</first_page>
            <cYear>2015</cYear>
            <doi>10.1902/jop.2014.140483</doi>
            <unstructured_citation>
                    Borg TD, Mealey BL. 
                    Histologic healing following tooth extraction with ridge preservation using mineralized versus combined mineralized-demineralized freeze-dried bone allograft: A randomized controlled clinical trial. 
                    J Periodontol  
                    2015; 
                    86
                    (3)
                    : 348-55.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref46">
            <journal_title>J. Clin. Periodontol.</journal_title>
            <author>Barone A.</author>
            <volume>44</volume>
            <first_page>204</first_page>
            <cYear>2017</cYear>
            <doi>10.1111/jcpe.12655</doi>
            <unstructured_citation>
                    Barone A, Toti P, Quaranta A, et al. 
                    Clinical and Histological changes after ridge preservation with two xenografts: Preliminary results from a multicentre randomized controlled clinical trial. 
                    J Clin Periodontol  
                    2017; 
                    44
                    (2)
                    : 204-14.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref47">
            <journal_title>Int. J. Oral Maxillofac. Implants</journal_title>
            <author>Heberer S.</author>
            <volume>26</volume>
            <first_page>385</first_page>
            <cYear>2011</cYear>
            <unstructured_citation>
                    Heberer S, Al-Chawaf B, Jablonski C, Nelson JJ, Lage H, Nelson K. 
                    Healing of ungrafted and grafted extraction sockets after 12 weeks: A prospective clinical study. 
                    Int J Oral Maxillofac Implants  
                    2011; 
                    26
                    (2)
                    : 385-92.
                    
                    
                </unstructured_citation>
          </citation>
        </citation_list>
      </journal_article>
    </journal>
  </body>
</doi_batch>
