TODENTJ-25-03-2019_TODENTJ-12-811 1553507531 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 10 25 2018 12 1 Bennett T. Amaechi Hariyali Kasundra Deepika Joshi Azadeh Abdollahi Parveez A. A. Azees Linda O. Okoye Objectives: Using an established pH-cycling caries model, the authors evaluated the effectiveness of toothpastes containing Surface Pre-reacted Glass-ionomer filler (S-PRG) in preventing tooth surface demineralization. Materials and Methods: 210 tooth blocks were randomly assigned to seven experimental groups (30 blocks/group): no treatment (A), and toothpaste containing either NaF (B), 0 wt% S-PRG (C), 1 wt% S-PRG (D), 5 wt% S-PRG (E), 20 wt% S-PRG (F) or 30 wt% S-PRG (G). Groups were subjected to 14-day demineralization for development of early caries lesions using a pH-cycling caries model. Demineralization was assessed using Quantitative Light-induced Fluorescence (QLF) and Transverse Microradiography (TMR). All pairwise contrasts (between treatments) were tested using Analysis of Variance (ANOVA), and then Tukey’s HSD for multiple comparisons. All p-values are considered significant if <0.05. Results: With QLF, there was a significant (ANOVA; p<0.001) difference in mean percent fluorescence loss (∆F) observed among the groups. Relative to control, all S-PRG-containing toothpastes significantly (Tukey’s; p<0.0001) inhibited demineralization at varying percentages (48.6%, 61.3%, 67.4% and 69.8% reduction with S-PRG 1%, 5%, 20% and 30% respectively). Demineralization reduction was not significant with either NaF (15.6% reduction) or 0% S-PRG (-2.5% reduction i.e. 2.5% more demineralization than the Control) when compared to control group. Mineral loss assessed using TMR followed a similar trend as fluorescence loss. Conclusion: Toothpaste containing S-PRG filler can serve as an effective caries control tool. S-PRG filler-containing dentifrice to be more effective in preventing tooth demineralization than 1100 ppm fluoride provided as sodium fluoride. 10 25 2018 811 819 TODENTJ-12-811 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2018-7-13 2018-8-23 2018-10-2 2018-10-25 https://creativecommons.org/licenses/by/4.0/legalcode 10.2174/1874210601812010811 1553507531 https://opendentistryjournal.com/VOLUME/12/PAGE/811/ https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-811/TODENTJ-12-811.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-811/TODENTJ-12-811.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-811/TODENTJ-12-811.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-811/TODENTJ-12-811.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-811/TODENTJ-12-811.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-811/TODENTJ-12-811.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-811/TODENTJ-12-811.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-811/TODENTJ-12-811.xml J. 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