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        <full_title>The Open Dentistry Journal</full_title>
        <abbrev_title>TODENTJ</abbrev_title>
        <issn media_type="print">1874-2106</issn>
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        <publication_date media_type="print">
          <month>04</month>
          <day>30</day>
          <year>2018</year>
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        <journal_volume>
          <volume>12</volume>
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        <issue>1</issue>
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        <titles>
          <title>Oral Ketorolac with Inferior Alveolar Nerve Block for Irreversible Pulpitis: A Systematic Review and Meta-analysis</title>
        </titles>
        <contributors>
          <person_name contributor_role="author" sequence="first">
            <given_name>Gowri</given_name>
            <surname>Sivaramakrishnan</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Kannan</given_name>
            <surname>Sridharan</surname>
          </person_name>
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        <jats:abstract>
                <jats:sec>
                    <jats:title>Background:</jats:title>
                    <jats:p>Ketorolac has advantages over other analgesics as a pre-anaesthetic medication. Considering this in mind, the present meta-analysis aims to identify the effect of oral ketorolac premedication on the anaesthetic efficacy of Inferior Alveolar Nerve Block (IANB) in patients with irreversible pulpitis.</jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Methods:</jats:title>
                    <jats:p>Full-texts of eligible studies were obtained from electronic databases. The extracted data was analysed using non-Cochrane mode in RevMan 5.0 software. Relative risk [95% CI] was calculated for the success of IANB.</jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Results:</jats:title>
                    <jats:p>Four studies were included for the final review. The success rate of IANB on 221 patients with relative risk of 1.87 [1.36, 2.56] was statistically significant favouring ketorolac. The mean difference for VAS in 171 patients was not statistically significant {-13.55 [-33.91, 6.82]}.</jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Conclusion:</jats:title>
                    <jats:p>Oral ketorolac can be successfully administered as a premedication before conventional inferior alveolar nerve block for endodontic treatment for irreversible pulpitis.</jats:p>
                </jats:sec>
            </jats:abstract>
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          <month>04</month>
          <day>30</day>
          <year>2018</year>
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          <first_page>340</first_page>
          <last_page>346</last_page>
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        <citation_list>
          <citation key="ref1">
            <unstructured_citation>
                    Reader A, Nusstein J, Drum M. 
                    Endodontic anaesthesia -Successful local anaesthesia for restorative dentistry and endodontics.
                    
                  Hanover Park II: Quintessence Publishings 2011; 131-48.</unstructured_citation>
          </citation>
          <citation key="ref2">
            <journal_title>J. Endod.</journal_title>
            <author>Parirokh M.</author>
            <volume>36</volume>
            <first_page>1450</first_page>
            <cYear>2010</cYear>
            <doi>10.1016/j.joen.2010.05.007</doi>
            <unstructured_citation>
                    Parirokh M, Ashouri R, Rekabi AR, et al. 
                    The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis. 
                    J Endod  
                    2010; 
                    36
                    (9)
                    : 1450-4.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref3">
            <journal_title>Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.</journal_title>
            <author>Modaresi J.</author>
            <volume>102</volume>
            <first_page>399</first_page>
            <cYear>2006</cYear>
            <doi>10.1016/j.tripleo.2005.10.053</doi>
            <unstructured_citation>
                    Modaresi J, Dianat O, Mozayeni MA. 
                    The efficacy comparison of ibuprofen, acetaminophen-codeine, and placebo premedication therapy on the depth of anesthesia during treatment of inflamed teeth. 
                    Oral Surg Oral Med Oral Pathol Oral Radiol Endod  
                    2006; 
                    102
                    (3)
                    : 399-403.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref4">
            <journal_title>J. Endod.</journal_title>
            <author>Lindemann M.</author>
            <volume>34</volume>
            <first_page>1167</first_page>
            <cYear>2008</cYear>
            <doi>10.1016/j.joen.2008.07.013</doi>
            <unstructured_citation>
                    Lindemann M, Reader A, Nusstein J, Drum M, Beck M. 
                    Effect of sublingual triazolam on the success of inferior alveolar nerve block in patients with irreversible pulpitis. 
                    J Endod  
                    2008; 
                    34
                    (10)
                    : 1167-70.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref5">
            <journal_title>J. Endod.</journal_title>
            <author>Aggarwal V.</author>
            <volume>37</volume>
            <first_page>445</first_page>
            <cYear>2011</cYear>
            <doi>10.1016/j.joen.2011.01.016</doi>
            <unstructured_citation>
                    Aggarwal V, Singla M, Rizvi A, Miglani S. 
                    Comparative evaluation of local infiltration of articaine, articaine plus ketorolac, and dexamethasone on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis. 
                    J Endod  
                    2011; 
                    37
                    (4)
                    : 445-9.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref6">
            <journal_title>Free Radic. Biol. Med.</journal_title>
            <author>Fernandes E.</author>
            <volume>37</volume>
            <first_page>1895</first_page>
            <cYear>2004</cYear>
            <doi>10.1016/j.freeradbiomed.2004.09.001</doi>
            <unstructured_citation>
                    Fernandes E, Costa D, Toste SA, Lima JL, Reis S. 
                    
                        In vitro scavenging activity for reactive oxygen and nitrogen species by nonsteroidal anti-inflammatory indole, pyrrole, and oxazole derivative drugs. 
                    Free Radic Biol Med  
                    2004; 
                    37
                    (11)
                    : 1895-905.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref7">
            <journal_title>J. Pain Symptom Manage.</journal_title>
            <author>Joishy S.K.</author>
            <volume>16</volume>
            <first_page>334</first_page>
            <cYear>1998</cYear>
            <doi>10.1016/S0885-3924(98)00081-5</doi>
            <unstructured_citation>
                    Joishy SK, Walsh D. 
                    The opioid-sparing effects of intravenous ketorolac as an adjuvant analgesic in cancer pain: Application in bone metastases and the opioid bowel syndrome. 
                    J Pain Symptom Manage  
                    1998; 
                    16
                    (5)
                    : 334-9.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref8">
            <journal_title>J Paramedic Practice</journal_title>
            <author>Mallinson T.E.</author>
            <volume>9</volume>
            <first_page>522</first_page>
            <cYear>2017</cYear>
            <doi>10.12968/jpar.2017.9.12.522</doi>
            <unstructured_citation>
                    Mallinson TE. 
                    A review of ketorolac as a prehospital analgesic. 
                    J Paramedic Practice  
                    2017; 
                    9
                    : 522-7.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref9">
            <journal_title>J. Endod.</journal_title>
            <author>Tortamano I.P.</author>
            <volume>35</volume>
            <first_page>165</first_page>
            <cYear>2009</cYear>
            <doi>10.1016/j.joen.2008.10.020</doi>
            <unstructured_citation>
                    Tortamano IP, Siviero M, Costa CG, Buscariolo IA, Armonia PL. 
                    A comparison of the anesthetic efficacy of articaine and lidocaine in patients with irreversible pulpitis. 
                    J Endod  
                    2009; 
                    35
                    (2)
                    : 165-8.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref10">
            <unstructured_citation>
                    Higgins JPT, Green S. 
                    Cochrane Handbook for Systematic Reviews of Interventions. 5.1.0 2011.
                    
                 Available from www.cochrane-handbook.org</unstructured_citation>
          </citation>
          <citation key="ref11">
            <journal_title>J. Clin. Epidemiol.</journal_title>
            <author>Moher D.</author>
            <volume>62</volume>
            <first_page>1006</first_page>
            <cYear>2009</cYear>
            <doi>10.1016/j.jclinepi.2009.06.005</doi>
            <unstructured_citation>
                    Moher D, Liberati A, Tetzlaff J, Altman DG. 
                    Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. 
                    J Clin Epidemiol  
                    2009; 
                    62
                    (10)
                    : 1006-12.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref12">
            <journal_title>J. Conserv. Dent.</journal_title>
            <author>Jena A.</author>
            <volume>16</volume>
            <first_page>171</first_page>
            <cYear>2013</cYear>
            <doi>10.4103/0972-0707.108209</doi>
            <unstructured_citation>
                    Jena A, Shashirekha G. 
                    Effect of preoperative medications on the efficacy of inferior alveolar nerve block in patients with irreversible pulpitis: A placebo-controlled clinical study. 
                    J Conserv Dent  
                    2013; 
                    16
                    (2)
                    : 171-4.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref13">
            <journal_title>J. Clin. Diagn. Res.</journal_title>
            <author>Saha S.G.</author>
            <volume>10</volume>
            <first_page>ZC25</first_page>
            <cYear>2016</cYear>
            <unstructured_citation>
                    Saha SG, Jain S, Dubey S, Kala S, Misuriya A, Kataria D. 
                    Effect of oral premedication on the efficacy of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: A prospective, double-Blind, randomized controlled clinical trial. 
                    J Clin Diagn Res  
                    2016; 
                    10
                    (2)
                    : ZC25-9.
                    
                    
                    
                 [JCDR].</unstructured_citation>
          </citation>
          <citation key="ref14">
            <journal_title>J. Endod.</journal_title>
            <author>Aggarwal V.</author>
            <volume>36</volume>
            <first_page>375</first_page>
            <cYear>2010</cYear>
            <doi>10.1016/j.joen.2009.11.010</doi>
            <unstructured_citation>
                    Aggarwal V, Singla M, Kabi D. 
                    Comparative evaluation of effect of preoperative oral medication of ibuprofen and ketorolac on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis: A prospective, double-blind, randomized clinical trial. 
                    J Endod  
                    2010; 
                    36
                    (3)
                    : 375-8.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref15">
            <journal_title>J. Endod.</journal_title>
            <author>Yadav M.</author>
            <volume>41</volume>
            <first_page>1773</first_page>
            <cYear>2015</cYear>
            <doi>10.1016/j.joen.2015.06.008</doi>
            <unstructured_citation>
                    Yadav M, Grewal MS, Grewal S, Deshwal P. 
                    Comparison of preoperative oral ketorolac on anesthetic efficacy of inferior alveolar nerve block and buccal and lingual infiltration with articaine and lidocaine in patients with irreversible pulpitis: A prospective, randomized, controlled, double-blind study. 
                    J Endod  
                    2015; 
                    41
                    (11)
                    : 1773-7.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref16">
            <journal_title>J. Am. Dent. Assoc.</journal_title>
            <author>Kaufman E.</author>
            <volume>108</volume>
            <first_page>205</first_page>
            <cYear>1984</cYear>
            <doi>10.14219/jada.archive.1984.0470</doi>
            <unstructured_citation>
                    Kaufman E, Weinstein P, Milgrom P. 
                    Difficulties in achieving local anesthesia. 
                    J Am Dent Assoc  
                    1984; 
                    108
                    (2)
                    : 205-8.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref17">
            <journal_title>J. Endod.</journal_title>
            <author>Dreven L.J.</author>
            <volume>13</volume>
            <first_page>233</first_page>
            <cYear>1987</cYear>
            <doi>10.1016/S0099-2399(87)80097-3</doi>
            <unstructured_citation>
                    Dreven LJ, Reader A, Beck M, Meyers WJ, Weaver J. 
                    An evaluation of an electric pulp tester as a measure of analgesia in human vital teeth. 
                    J Endod  
                    1987; 
                    13
                    (5)
                    : 233-8.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref18">
            <journal_title>Endod. Dent. Traumatol.</journal_title>
            <author>Potočnik I.</author>
            <volume>15</volume>
            <first_page>247</first_page>
            <cYear>1999</cYear>
            <doi>10.1111/j.1600-9657.1999.tb00782.x</doi>
            <unstructured_citation>
                    Potočnik I, Bajrović F. 
                    Failure of inferior alveolar nerve block in endodontics. 
                    Endod Dent Traumatol  
                    1999; 
                    15
                    (6)
                    : 247-51.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref19">
            <journal_title>J. Am. Dent. Assoc.</journal_title>
            <author>Lapidus D.</author>
            <volume>147</volume>
            <first_page>427</first_page>
            <cYear>2016</cYear>
            <doi>10.1016/j.adaj.2016.01.006</doi>
            <unstructured_citation>
                    Lapidus D, Goldberg J, Hobbs EH, Ram S, Clark GT, Enciso R. 
                    Effect of premedication to provide analgesia as a supplement to inferior alveolar nerve block in patients with irreversible pulpitis. 
                    J Am Dent Assoc  
                    2016; 
                    147
                    (6)
                    : 427-37.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref20">
            <journal_title>J. Maxillofac. Oral Surg.</journal_title>
            <author>Shankariah M.</author>
            <volume>11</volume>
            <first_page>264</first_page>
            <cYear>2012</cYear>
            <doi>10.1007/s12663-011-0321-y</doi>
            <unstructured_citation>
                    Shankariah M, Mishra M, Kamath RA. 
                    Tramadol versus ketorolac in the treatment of postoperative pain following maxillofacial surgery. 
                    J Maxillofac Oral Surg  
                    2012; 
                    11
                    (3)
                    : 264-70.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref21">
            <journal_title>Clin. Oral Investig.</journal_title>
            <author>Shirvani A.</author>
            <volume>21</volume>
            <first_page>43</first_page>
            <cYear>2017</cYear>
            <doi>10.1007/s00784-016-1974-1</doi>
            <unstructured_citation>
                    Shirvani A, Shamszadeh S, Eghbal MJ, Marvasti LA, Asgary S. 
                    Effect of preoperative oral analgesics on pulpal anesthesia in patients with irreversible pulpitis: A systematic review and meta-analysis. 
                    Clin Oral Investig  
                    2017; 
                    21
                    (1)
                    : 43-52.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref22">
            <journal_title>J. Endod.</journal_title>
            <author>Praveen R.</author>
            <volume>43</volume>
            <first_page>667</first_page>
            <cYear>2017</cYear>
            <doi>10.1016/j.joen.2016.12.012</doi>
            <unstructured_citation>
                    Praveen R, Thakur S, Kirthiga M. 
                    Comparative evaluation of premedication with ketorolac and prednisolone on postendodontic pain: A double-blind randomized controlled trial. 
                    J Endod  
                    2017; 
                    43
                    (5)
                    : 667-73.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref23">
            <journal_title>J. Endod.</journal_title>
            <author>Akhlaghi N.M.</author>
            <volume>42</volume>
            <first_page>691</first_page>
            <cYear>2016</cYear>
            <doi>10.1016/j.joen.2016.02.003</doi>
            <unstructured_citation>
                    Akhlaghi NM, Hormozi B, Abbott PV, Khalilak Z. 
                    Efficacy of ketorolac buccal infiltrations and inferior alveolar nerve blocks in patients with irreversible pulpitis: A prospective, double-blind, randomized clinical trial. 
                    J Endod  
                    2016; 
                    42
                    (5)
                    : 691-5.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="ref24">
            <journal_title>J. Endod.</journal_title>
            <author>Stentz D.</author>
            <volume>44</volume>
            <first_page>9</first_page>
            <cYear>2018</cYear>
            <doi>10.1016/j.joen.2017.09.011</doi>
            <unstructured_citation>
                    Stentz D, Drum M, Reader A, Nusstein J, Fowler S, Beck M. 
                    Effect of a combination of intranasal ketorolac and nitrous oxide on the success of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: A prospective, randomized, double-blind study. 
                    J Endod  
                    2018; 
                    44
                    (1)
                    : 9-13.
                    
                    
                    
                </unstructured_citation>
          </citation>
        </citation_list>
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