TODENTJ-25-03-2019_TODENTJ-12-181 1553507313 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 02 28 2018 12 1 Giuseppe Troiano Luigi Laino Marco Cicciù Gabriele Cervino Luca Fiorillo Cesare D’amico Khrystyna Zhurakivska Lorenzo Lo Muzio The aim of this systematic review and meta-analysis was to compare the clinical efficacy of two routes of dexamethasone administration in reducing the postoperative sequelae after third molar extraction. Electronic databases (PUBMED, SCOPUS and EBSCO library) were screened in order to find both randomized and non-randomized clinical trials that directly compare the submucosal intraoral or the intramuscular extraoral administration of dexamethasone. No restriction about year of publication was imposed. About 340 titles and abstracts were screened independently by two authors. Of these [340 titles], only 4 randomized clinical trials met the inclusion criteria and were included in the meta-analysis. No statistical differences in postoperative pain, swelling and trismus were recorded comparing the intraoral submucosal and the extraoral intramuscular injection of dexamethasone in an extra-oral site. 02 28 2018 181 188 TODENTJ-12-181 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2017-12-30 2018-02-07 2018-02-13 2018-02-28 https://creativecommons.org/licenses/by/4.0/legalcode 10.2174/1874210601812010181 1553507313 https://opendentistryjournal.com/VOLUME/12/PAGE/181/ https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-181/TODENTJ-12-181.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-181/TODENTJ-12-181.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-181/TODENTJ-12-181.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-181/TODENTJ-12-181.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-181/TODENTJ-12-181.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-181/TODENTJ-12-181.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-181/TODENTJ-12-181.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-181/TODENTJ-12-181.xml Oral Surg. 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