TODENTJ-25-03-2019_TODENTJ-12-133 1553507305 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 02 12 2018 12 1 Mohammad Jalaluddin Jayachandran Mahesh Rethi Mahesh Ipsita Jayanti Mohamed Faizuddin Krishna Kripal Nazia Nazeer Background & Objectives: Periodontal disease is characterized by the presence of gingival inflammation, periodontal pocket formation, loss of connective tissue attachment and alveolar bone around the affected tooth. Different modalities have been employed in the treatment and regeneration of periodontal defects which include the use of bone grafts, PRP and other growth factors.The purpose of this prospective, randomized controlled study was to compare the regenerative efficacy of PRP and bonegraft in intrabony periodontal defects. Methodology: This randomized control trial was carried out in the Department of Periodontics & Oral Implantology, Kalinga Institute of Dental Sciences and Hospital, KIIT University, Bhubaneswar. The study sample included 20 periodontal infrabony defects in 20 patients, 12 males and 8 females. The patients were aged between 25 -45 years(with mean age of 35 years). The 20 sites selected for the study were was randomly divided into 2 groups of 10 sites each. Group A: PRP alone, Group B: Bone Graft. Statistical Anaysis & Results: Statistical Analysis Was Done Using SPSS (Version 18.0): Statistical analysis was done usingpaired ‘t’ tests and ANOVA that revealed a significant reduction ingingival index, plaque index, probing pocket depth and gain in clinical attachment level at various time intervalswithin both the groups. Radiographic evaluation revealed statistically significant defect fill (p<0.001) at the end of 6months within both the groups. However, there was astatistically significant difference seen in group B radiographically, when compared to group A. Conclusion: Both the groups showed promising results in enhancing periodontal regeneration; however the resultswith bonegraftwere comparatively better, although not statistically significant when compared to PRP alone. 02 12 2018 133 154 TODENTJ-12-133 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2017-11-17 2017-11-30 2017-12-5 2018-02-12 https://creativecommons.org/licenses/by/4.0/legalcode 10.2174/1874210601812010133 1553507305 https://opendentistryjournal.com/VOLUME/12/PAGE/133/ https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-133/TODENTJ-12-133.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-133/TODENTJ-12-133.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-133/TODENTJ-12-133.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-133/TODENTJ-12-133.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-133/TODENTJ-12-133.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-133/TODENTJ-12-133.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-133/TODENTJ-12-133.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-133/TODENTJ-12-133.xml Materials (Basel) Park C.H. 9 57 2016 10.3390/ma9010057 Park CH, Kim K-H, Lee YM, Seol YJ. 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