TODENTJ-25-03-2019_TODENTJ-12-1147 1553507691 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 12 31 2018 12 1 Federico Berton Pipinato Giulia Maglione Michele Baldi Domenico Di Lenarda Roberto Stacchi Claudio Introduction: Parotid gland swelling, caused by many pathological conditions, has also been reported to be a possible side effect of the use of chlorhexidine mouthwash. This adverse reaction to chlorhexidine mouthwash is, however, extremely rare and very few cases of parotid gland swelling due to chlorhexidine mouthwash have been reported in the literature. Case Description: This report describes the clinical management of unilateral parotid swelling caused by chlorhexidine mouthwash. Methods: A patient presented with left parotid gland swelling after using chlorhexidine mouthwash for three days following sinus augmentation on the contralateral side of the maxilla. Diagnosis of parotid gland swelling due to rinsing with chlorhexidine was formulated after anamnesis, clinical examination, radiographs and ultrasound of the gland excluded other pathological conditions. The patient was subsequently advised to stop rinsing. However, on the evening of the same day, swelling increased and the patient presented to an emergency department where a single intravenous dose of methylprednisolone was administered. Results: After seven days, parotid swelling decreased significantly and after three weeks had completely disappeared. Conclusion: Although unilateral or bilateral parotid gland swelling related to the use of chlorhexidine mouthwash is an uncommon adverse event, it must be suspected after other organic or infective conditions have been excluded. The precise pathogenic mechanism has not yet been determined and further studies should be carried out to better understand the pathophysiology of this uncommon phenomenon. 12 31 2018 1147 1151 TODENTJ-12-1147 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2018-11-7 2018-12-5 2018-12-21 2018-12-31 https://creativecommons.org/licenses/by/4.0/legalcode 10.2174/1874210601812011147 1553507691 https://opendentistryjournal.com/VOLUME/12/PAGE/1147/ https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1147/TODENTJ-12-1147.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1147/TODENTJ-12-1147.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1147/TODENTJ-12-1147.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1147/TODENTJ-12-1147.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1147/TODENTJ-12-1147.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1147/TODENTJ-12-1147.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1147/TODENTJ-12-1147.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1147/TODENTJ-12-1147.xml Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. Mandel L. 93 221 2002 10.1067/moe.2002.121163 Mandel L, Surattanont F. Bilateral parotid swelling: A review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 93 (3) : 221-37. Neville BW, Damm DD, Allen CM, Chi AC. Oral and maxillofacial pathology 4th ed. 2016. Addy M, Moran J. Clinical periodontology and implant dentistry 2008; 744-65. Scand. J. Dent. Res. Flötra L. 79 119 1971 Flötra L, Gjermo P, Rölla G, Waerhaug J. Side effects of chlorhexidine mouth washes. Scand J Dent Res 1971; 79 (2) : 119-25. Int. J. Dent. Hyg. Van der Weijden G.A. 8 276 2010 10.1111/j.1601-5037.2009.00419.x Van der Weijden GA, Ten Heggeler JM, Slot DE, Rosema NA, Van der Velden U. Parotid gland swelling following mouthrinse use. Int J Dent Hyg 2010; 8 (4) : 276-9. J. Am. Dent. Assoc. McCoy L.C. 139 178 2008 10.14219/jada.archive.2008.0134 McCoy LC, Wehler CJ, Rich SE, Garcia RI, Miller DR, Jones JA. Adverse events associated with chlorhexidine use: results from the Department of Veterans Affairs Dental Diabetes Study. J Am Dent Assoc 2008; 139 (2) : 178-83. Clin. Implant Dent. Relat. Res. Stacchi C. 17 e117 2015 10.1111/cid.12136 Stacchi C, Vercellotti T, Toschetti A, Speroni S, Salgarello S, Di Lenarda R. Intraoperative complications during sinus floor elevation using two different ultrasonic approaches: A two-center, randomized, controlled clinical trial. Clin Implant Dent Relat Res 2015; 17 (Suppl. 1) : e117-25. J. Craniofac. Surg. Stacchi C. 28 1191 2017 10.1097/SCS.0000000000003636 Stacchi C, Lombardi T, Cusimano P, et al. Bone scrapers versus piezoelectric surgery in the lateral antrostomy for sinus floor elevation. J Craniofac Surg 2017; 28 (5) : 1191-6. J. Clin. Periodontol. Rushton A. 4 73 1977 10.1111/j.1600-051X.1977.tb00053.x Rushton A. Safety of hibitane. II. Human experience. J Clin Periodontol 1977; 4 (5) : 73-9.