TODENTJ-25-03-2019_TODENTJ-12-1079
1553507675
Bentham Open
doi@benthamopen.net
Bentham Open
The Open Dentistry Journal
TODENTJ
1874-2106
12
31
2018
12
1
Peripheral Odontogenic Myxoma: Report of Two New Cases with a Critical Review of the Literature
Marco
Mascitti
Lucrezia
Togni
Filippo
Pirani
Corrado
Rubini
Andrea
Santarelli
Introduction:
Odontogenic myxoma is a benign mesenchymal odontogenic tumor that is more frequently found in the mandibular molar region. The extra-osseous counterpart, called Peripheral Odontogenic Myxoma (POM), is an exceedingly rare entity and with very low aggressive potential.
Methods:
Clinical and radiographic findings are not specific, and difficulties may exist in differentiating histological findings of POM from other tumors with myxoid features, such as fibromas and oral focal mucinosis. Due to the fact that the presence of odontogenic epithelium is not required for the diagnosis, a myxoid lesion without odontogenic nests that develops in extraosseous position can be misdiagnosed with a soft tissue myxoma.
Case Reports:
We thereby present two cases of POM and conduct an extensive and critical review of the English literature, taking into consideration both certain and putative cases of POM.
12
31
2018
1079
1090
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Oral Surg. Oral Med. Oral Pathol.
Thoma K.H.
33
B532
1947
Thoma KH, Goldman HM.
Central myxoma of the jaw.
Oral Surg Oral Med Oral Pathol
1947;
33
(7)
: B532-40.
Ann. Surg.
Stout A.P.
127
706
1948
10.1097/00000658-194804000-00013
Stout AP.
Myxoma, the tumor of primitive mesenchyme.
Ann Surg
1948;
127
(4)
: 706-19.
El-Naggar AK, Chan JKC, Rubin Grandis J, Takata T, Slootweg PJ, Eds.
WHO classification of head and neck tumours
2017;
347.
J. Indian Soc. Periodontol.
Jain V.K.
17
653
2013
10.4103/0972-124X.119287
Jain VK, Reddy SN.
Peripheral odontogenic myxoma of maxillary gingiva: A rare clinical entity.
J Indian Soc Periodontol
2013;
17
(5)
: 653-6.
J. Coll. Physicians Surg. Pak.
Bajpai M.
27
S28
2017
Bajpai M, Pardhe N.
Extra-Osseous Odontogenic Myxoma of Maxillary Gingiva.
J Coll Physicians Surg Pak
2017;
27
(3)
: S28-9.
J. Maxillofac. Oral Surg.
Raubenheimer E.J.
11
101
2012
10.1007/s12663-011-0194-0
Raubenheimer EJ, Noffke CE.
Peripheral odontogenic myxoma: A review of the literature and report of two cases.
J Maxillofac Oral Surg
2012;
11
(1)
: 101-4.
J. Clin. Periodontol.
Perrotti V.
33
76
2006
10.1111/j.1600-051X.2005.00837.x
Perrotti V, Rubini C, Fioroni M, Piattelli A.
Soft tissue myxoma: report of an unusual case located on the gingiva.
J Clin Periodontol
2006;
33
(1)
: 76-8.
J. Clin. Diagn. Res.
Shenoy V.S.
8
KD01
2014
Shenoy VS, Rao RA, Prasad V, Kamath PM, Rao KS.
Soft tissue myxoma: A rare differential diagnosis of localized oral cavity lesions.
J Clin Diagn Res
2014;
8
(12)
: KD01-2.
J. Korean Assoc. Oral Maxillofac. Surg.
Kanitkar S.
43
178
2017
10.5125/jkaoms.2017.43.3.178
Kanitkar S, Kamat M, Tamagond S, Varekar A, Datar U.
Peripheral odontogenic myxoma in a 12-year-old girl: A rare entity.
J Korean Assoc Oral Maxillofac Surg
2017;
43
(3)
: 178-81.
J. Oral Sci.
Mascitti M.
58
459
2016
10.2334/josnusd.16-0147
Mascitti M, Santarelli A, Zizzi A, Procaccini M, Lo Muzio L, Rubini C.
Expression of p73 and TRAIL in odontogenic cysts and tumors.
J Oral Sci
2016;
58
(4)
: 459-64.
Cancer
Dutz W.
14
629
1961
10.1002/1097-0142(199005/06)14:3<629::AID-CNCR2820140325>3.0.CO;2-J
Dutz W, Stout AP.
The myxoma in childhood.
Cancer
1961;
14
: 629-35.
Ann. Diagn. Pathol.
Allen P.W.
4
99
2000
10.1016/S1092-9134(00)90019-4
Allen PW.
Myxoma is not a single entity: A review of the concept of myxoma.
Ann Diagn Pathol
2000;
4
(2)
: 99-123.
Barnes L, Eveson JW, Reichart P, Sidransky D, Eds.
Pathology and genetics of head and neck tumours
2005.
Pathologica
Rubini C.
109
35
2017
Rubini C, Mascitti M, Santarelli A, et al.
Odontogenic tumors: A retrospective clinicopathological study from two Italian centers.
Pathologica
2017;
109
(1)
: 35-46.
Oral Surg. Oral Med. Oral Pathol.
Stanley H.R.
12
760
1959
10.1016/0030-4220(59)90124-0
Stanley HR Jr, Krogh HW.
Peripheral ameloblastoma; Report of a case.
Oral Surg Oral Med Oral Pathol
1959;
12
(6)
: 760-5.
Int. J. Oral Maxillofac. Surg.
Manor Y.
33
268
2004
10.1006/ijom.2003.0508
Manor Y, Mardinger O, Katz J, Taicher S, Hirshberg A.
Peripheral odontogenic tumours: Differential diagnosis in gingival lesions.
Int J Oral Maxillofac Surg
2004;
33
(3)
: 268-73.
J. Oral Pathol.
Gundlach K.K.
6
343
1977
10.1111/j.1600-0714.1977.tb01800.x
Gundlach KK, Schulz A.
Odontogenic myxoma: Clinical concept and morphological studies.
J Oral Pathol
1977;
6
(6)
: 343-58.
J. Maxillofac. Surg.
Schmidseder R.
6
281
1978
10.1016/S0301-0503(78)80107-6
Schmidseder R, Groddeck A, Scheunemann H.
Diagnostic and therapeutic problems of myxomas (myxofibromas) of the jaws.
J Maxillofac Surg
1978;
6
(4)
: 281-6.
10.3109/00016355809064114
Pindborg JJ, Clausen F.
Classification of odontogenic tumors: A suggestion.
Acta odont Scand
1958;
16
: 293-301.
J. Oral Maxillofac. Surg.
Epivatianos A.
65
317
2007
10.1016/j.joms.2006.03.026
Epivatianos A, Iordanidis S, Zaraboukas T.
Myxoma of the oral soft tissues: Report of a case and literature review.
J Oral Maxillofac Surg
2007;
65
(2)
: 317-20.
Indian J. Dent. Res.
Tasnime S.
27
437
2016
10.4103/0970-9290.191896
Tasnime S, Saxena C, Bansal V, Wadhwan V.
Peripheral odontogenic myxoma.
Indian J Dent Res
2016;
27
(4)
: 437-40.
Head Neck Surg.
Tse J.J.
7
479
1985
10.1002/hed.2890070608
Tse JJ, Vander S.
The soft tissue myxoma of the head and neck region: Report of a case and literature review.
Head Neck Surg
1985;
7
(6)
: 479-83.
Am. J. Otolaryngol.
Andrews T.
21
184
2000
10.1016/S0196-0709(00)85022-X
Andrews T, Kountakis SE, Maillard AA.
Myxomas of the head and neck.
Am J Otolaryngol
2000;
21
(3)
: 184-9.
J. Biol. Regul. Homeost. Agents
Santarelli A.
28
523
2014
Santarelli A, Mascitti M, Orsini G, et al.
Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
J Biol Regul Homeost Agents
2014;
28
(3)
: 523-9.
Oral Oncol.
Philipsen H.P.
37
17
2001
10.1016/S1368-8375(00)00064-6
Philipsen HP, Reichart PA, Nikai H, Takata T, Kudo Y.
Peripheral ameloblastoma: biological profile based on 160 cases from the literature.
Oral Oncol
2001;
37
(1)
: 17-27.
J. Periodontol.
Schneider L.C.
46
493
1975
10.1902/jop.1975.46.8.493
Schneider LC, Weisinger E.
Odontogenic fibromyxoma arising from the periodontal ligament.
J Periodontol
1975;
46
(8)
: 493-7.
J. Oral Biol. Craniofac. Res.
Kapoor P.
5
232
2015
10.1016/j.jobcr.2015.07.004
Kapoor P, Gandhewar TM, Andrade NN, Desai RS.
Peripheral myxoma of the infratemporal region: An unusual case report.
J Oral Biol Craniofac Res
2015;
5
(3)
: 232-5.
Lancet
Daniels D.W.
172
1747
1908
10.1016/S0140-6736(00)69571-5
Daniels DW.
M.B. L. A case of pure myxoma of the lower jaw.
Lancet
1908;
172
: 1747.
Trans Am Laryngol Rhinol Otol
Tholen E.F.
42
608
1936
Tholen EF.
Myxomata of the jaw and pharynx.
Trans Am Laryngol Rhinol Otol
1936;
42
: 608.
Arch. Otolaryngol.
Babbit J.A.
26
453
1937
10.1001/archotol.1937.00650020495008
Babbit JA, Pfeiffer DB.
Myxoma of the palate and pharynx.
Arch Otolaryngol
1937;
26
: 453.
Aust. Dent. J.
Sealey V.T.
52
177
1948
Sealey VT.
An unusual tumour on the palate.
Aust Dent J
1948;
52
(3)
: 177.
Oral Surg. Oral Med. Oral Pathol.
Salama N.
4
966
1951
10.1016/0030-4220(51)90443-4
Salama N, Hilmy A.
Cases from the clinic of the Cairo Dental School.
Oral Surg Oral Med Oral Pathol
1951;
4
(8)
: 966-84.
Int. Surg.
Pradhan A.C.
57
341
1972
Pradhan AC, Varma RK, Pradhan S.
Myxoma of the hard palate.
Int Surg
1972;
57
(4)
: 341.
Br. J. Oral Surg.
Tahsinoğlu M.
13
95
1975
10.1016/0007-117X(75)90029-3
Tahsinoğlu M, Cöloğlu AS, Kuralay T.
Myxoma of the gingiva: A case report.
Br J Oral Surg
1975;
13
(1)
: 95-7.
J. Oral Surg.
Matsumara T.
35
313
1977
Matsumara T, Hasegawa K, Isono K, Kawakatsu K.
Congenital fibromyxoma: Report of case.
J Oral Surg
1977;
35
(4)
: 313-5.
J. Oral Surg.
Swart J.G.
35
501
1977
Swart JG, van der Kwast WA, Snow GB, van der Waal I.
Possible myxoma of the floor of the mouth: Report of case.
J Oral Surg
1977;
35
(6)
: 501-3.
Oral Surg. Oral Med. Oral Pathol.
Elzay R.P.
45
246
1978
10.1016/0030-4220(78)90091-9
Elzay RP, Dutz W.
Myxomas of the paraoral: Oral soft tissues.
Oral Surg Oral Med Oral Pathol
1978;
45
(2)
: 246-54.
J. Oral Maxillofac. Surg.
Rapidis A.D.
41
188
1983
10.1016/0278-2391(83)90080-0
Rapidis AD, Triantafyllou AG.
Myxoma of the oral soft tissues.
J Oral Maxillofac Surg
1983;
41
(3)
: 188-92.
J. Nihon Univ. Sch. Dent.
Nakano Y.
27
119
1985
10.2334/josnusd1959.27.119
Nakano Y, Yamamoto H, Shiozaki H, et al.
Peripheral myxoma of the right maxilla: A case and review of the Japanese literature.
J Nihon Univ Sch Dent
1985;
27
(2)
: 119-25.
J. Oral Med.
Siar C.H.
41
256
1986
Siar CH, Ng KH, Devadas V, Patricia M.
Oral soft tissue myxoma. Report of a case.
J Oral Med
1986;
41
(4)
: 256-8.
J. Periodontol.
Günhan O.
62
387
1991
10.1902/jop.1991.62.6.387
Günhan O, Arpak N, Celasun B, Can C.
Odontogenic myxoma. Report of a periodontally-located case.
J Periodontol
1991;
62
(6)
: 387-9.
J. Otolaryngol.
Quintal M.C.
23
42
1994
Quintal MC, Tabet JC, Oligny L, Russo P.
Oral soft tissue myxoma: Report of a case and review of the literature.
J Otolaryngol
1994;
23
(1)
: 42-5.
J. Oral Sci.
Shimoyama T.
42
107
2000
10.2334/josnusd.42.107
Shimoyama T, Horie N, Kato T, et al.
Soft tissue myxoma of the gingiva: Report of a case and review of the literature of soft tissue myxoma in the oral region.
J Oral Sci
2000;
42
(2)
: 107-9.
Chang Gung Med. J.
Chang S.H.
24
826
2001
Chang SH, Lee KF, Chan CP, Kuo SB.
Myxoma of the gingiva: A case report and literature review.
Chang Gung Med J
2001;
24
(12)
: 826-31.
Indian J. Dent. Res.
Ramaraj P.N.
14
67
2003
Ramaraj PN, Shah SP.
Peripheral myxoma of maxilla. A case report.
Indian J Dent Res
2003;
14
(1)
: 67-9.
Oral Maxillofac. Surg.
Aytac-Yazicioglu D.
12
167
2008
10.1007/s10006-008-0122-8
Aytac-Yazicioglu D, Eren H, Görgün S.
Peripheral odontogenic myxoma located on the maxillary gingiva: Report of a case and review of the literature.
Oral Maxillofac Surg
2008;
12
(3)
: 167-71.
J Oral Laser Applications
Nazarov K.
8
117
2008
Nazarov K, Ergun S, Çekici A, Tanyeri H, Ibrahim M, Ișik G.
Successful treatment of an odontogenic peripheral myxofibroma using diode laser.
J Oral Laser Applications
2008;
8
: 117-20.
Contemp. Clin. Dent.
Bhoyar N.
7
558
2016
10.4103/0976-237X.194120
Bhoyar N, Gupta S, Ghosh S.
Odontogenic myxofibroma of gingiva in a pediatric patient with tuberous sclerosis: A rare case report.
Contemp Clin Dent
2016;
7
(4)
: 558-61.