TODENTJ-25-03-2019_TODENTJ-12-1036 1553507637 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 11 30 2018 12 1 Nada Binmadi Chidan Intapa Risa Chaisuparat Sara Akeel Amal Sindi Timothy Meiller Background: Amyloidosis refers to a group of systemic and localized disorders associated with the accumulation of misfolded protein aggregates called amyloids in different parts of the body. Owing to the existence of multiple forms of amyloids with similar tertiary structures, precise identification of their biochemical form is critical for correct therapy. Objective: This retrospective study aimed to determine whether typing of oral amyloid deposits can help diagnose a serious systemic condition in the early phase of the disease Methods: All histopathologically confirmed cases of amyloidosis managed over a 14-year period (January 1, 1997 to December 31, 2011) were retrieved for analysis. Two board-certified oral and maxillofacial pathologists reviewed the histopathological findings of amyloidosis on the basis of its classic Congo red staining characteristics. This was followed by immunohistochemical analysis of biopsy samples using a panel of antibodies specific for different forms of amyloidosis. Results: The most common location of amyloidosis was the tongue, and women were more commonly affected than men. The patient age ranged from 11 to 83 years (average 59.3 years). In patient 9, light-chain and pre-albumin (transthyretin) antibodies were related to arthritis and senile amyloidosis, respectively. The biopsy sample of patient 10, who was reported to have multiple myeloma, was positive for light chains and β2 microglobulin. All other samples exhibited localized (solitary) amyloidosis. Conclusion: Histological analysis coupled with immunostaining with a panel of specific antibodies might assist in identifying early systemic amyloidosis in patients with localized oral forms of the disease. 11 30 2018 1036 1042 TODENTJ-12-1036 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2018-08-10 2018-10-26 2018-11-4 2018-11-30 https://creativecommons.org/licenses/by/4.0/legalcode 10.2174/1874210601812011036 1553507637 https://opendentistryjournal.com/VOLUME/12/PAGE/1036/ https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1036/TODENTJ-12-1036.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1036/TODENTJ-12-1036.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1036/TODENTJ-12-1036.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1036/TODENTJ-12-1036.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1036/TODENTJ-12-1036.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1036/TODENTJ-12-1036.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1036/TODENTJ-12-1036.pdf https://opendentistryjournal.com/contents/volumes/V12/TODENTJ-12-1036/TODENTJ-12-1036.xml Amyloid Sipe J.D. 21 221 2014 10.3109/13506129.2014.964858 Sipe JD, Benson MD, Buxbaum JN, et al. Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis. Amyloid 2014; 21 (4) : 221-4. Hematology (Am. Soc. Hematol. Educ. Program) Cohen A.D. 2010 287 2010 10.1182/asheducation-2010.1.287 Cohen AD, Comenzo RL. Systemic light-chain amyloidosis: Advances in diagnosis, prognosis, and therapy. Hematology (Am Soc Hematol Educ Program) 2010; 2010 : 287-94. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. Stoopler E.T. 95 674 2003 10.1067/moe.2003.136 Stoopler ET, Sollecito TP, Chen SY. Amyloid deposition in the oral cavity: A retrospective study and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 95 (6) : 674-80. N. Engl. J. Med. Lachmann H.J. 356 2361 2007 10.1056/NEJMoa070265 Lachmann HJ, Goodman HJ, Gilbertson JA, et al. Natural history and outcome in systemic AA amyloidosis. N Engl J Med 2007; 356 (23) : 2361-71. Arch. Pathol. Lab. Med. Picken M.M. 134 545 2010 Picken MM. Amyloidosis-where are we now and where are we heading? Arch Pathol Lab Med 2010; 134 (4) : 545-51. AJNR Am. J. Neuroradiol. Parmar H. 31 1165 2010 10.3174/ajnr.A1977 Parmar H, Rath T, Castillo M, Gandhi D. Imaging of focal amyloid depositions in the head, neck, and spine: Amyloidoma. AJNR Am J Neuroradiol 2010; 31 (7) : 1165-70. J. Neurol. Neurosurg. Psychiatry Sekijima Y. 86 1036 2015 10.1136/jnnp-2014-308724 Sekijima Y. Transthyretin (ATTR) amyloidosis: Clinical spectrum, molecular pathogenesis and disease-modifying treatments. J Neurol Neurosurg Psychiatry 2015; 86 (9) : 1036-43. J. Biol. Chem. Coetzee G.A. 261 9644 1986 Coetzee GA, Strachan AF, van der Westhuyzen DR, Hoppe HC, Jeenah MS, de Beer FC. Serum amyloid A-containing human high density lipoprotein 3. Density, size, and apolipoprotein composition. J Biol Chem 1986; 261 (21) : 9644-51. Am. J. Pathol. Benditt E.P. 65 231 1971 Benditt EP, Eriksen N. Chemical classes of amyloid substance. Am J Pathol 1971; 65 (1) : 231-52. Curr. Opin. Nephrol. Hypertens. Picken M.M. 16 196 2007 10.1097/MNH.0b013e3280bdc0db Picken MM. New insights into systemic amyloidosis: The importance of diagnosis of specific type. Curr Opin Nephrol Hypertens 2007; 16 (3) : 196-203. Methods Mol. Biol. Gras S.L. 752 197 2011 10.1007/978-1-60327-223-0_13 Gras SL, Waddington LJ, Goldie KN. Transmission electron microscopy of amyloid fibrils. Methods Mol Biol 2011; 752 : 197-214. J. Clin. Pathol. Deshmukh M. 62 724 2009 10.1136/jcp.2009.065474 Deshmukh M, Elderfield K, Rahemtulla A, Naresh KN. Immunophenotype of neoplastic plasma cells in AL amyloidosis. J Clin Pathol 2009; 62 (8) : 724-30. Blood Paiva B. 117 3613 2011 10.1182/blood-2010-12-324665 Paiva B, Vídriales MB, Pérez JJ, et al. The clinical utility and prognostic value of multiparameter flow cytometry immunophenotyping in light-chain amyloidosis. Blood 2011; 117 (13) : 3613-6. Chin. Med. J. (Engl.) Hu Y. 127 2765 2014 Hu Y, Wang M, Chen Y, et al. Immunophenotypic analysis of abnormal plasma cell clones in bone marrow of primary systemic light chain amyloidosis patients. Chin Med J (Engl) 2014; 127 (15) : 2765-70. Blood Muchtar E. 129 82 2017 10.1182/blood-2016-06-721878 Muchtar E, Jevremovic D, Dispenzieri A, et al. The prognostic value of multiparametric flow cytometry in aL amyloidosis at diagnosis and at the end of first-line treatment. Blood 2017; 129 (1) : 82-7. Clin. Oral Investig. Matsuo F.S. 20 1913 2016 10.1007/s00784-015-1649-3 Matsuo FS, Barbosa de Paulo LF, Servato JP, de Faria PR, Cardoso SV, Loyola AM. Involvement of oral tissues by AL amyloidosis: A literature review and report of eight new cases. Clin Oral Investig 2016; 20 (8) : 1913-20. Amyloid Shimojima Y. 12 33 2005 10.1080/02772240500032515 Shimojima Y, Matsuda M, Gono T, et al. Correlation between serum levels of free light chain and phenotype of plasma cells in bone marrow in primary AL amyloidosis. Amyloid 2005; 12 (1) : 33-40. Oral Dis. Deng J. 00 16 2018 Deng J, Chen Q, Ji P, Zeng X, Jin X. Oral amyloidosis: A strategy to differentiate systemic amyloidosis involving the oral cavity and localized amyloidosis. Oral Dis 2018; 00 : 16. Am. J. Kidney Dis. Manabe S. 66 1095 2015 10.1053/j.ajkd.2015.08.016 Manabe S, Hatano M, Yazaki M, Nitta K, Nagata M. Renal AH amyloidosis associated with a truncated immunoglobulin heavy chain undetectable by immunostaining. Am J Kidney Dis 2015; 66 (6) : 1095-100. Can. J. Ophthalmol. Latasiewicz M. 50 384 2015 10.1016/j.jcjo.2015.06.007 Latasiewicz M, Adan A, Solé M. Immunostaining images of vitreous transthyretin amyloid. Can J Ophthalmol 2015; 50 (5) : 384-7. Amyloid Hahn K. 24 78 2017 10.1080/13506129.2017.1316711 Hahn K, Nilsson KPR, Hammarström P, et al. Establishing and validating the fluorescent amyloid ligand h-FTAA (heptamer formyl thiophene acetic acid) to identify transthyretin amyloid deposits in carpal tunnel syndrome. Amyloid 2017; 24 (2) : 78-86. Ann. Nucl. Med. Ishii S. 26 522 2012 10.1007/s12149-012-0606-3 Ishii S, Kubota K, Minamimoto R, et al. Lung amyloid nodule detected by 99 m Tc-aprotinin scintigraphy. Ann Nucl Med 2012; 26 (6) : 522-6. J. Nucl. Cardiol. Aljaroudi W.A. 21 271 2014 10.1007/s12350-013-9800-5 Aljaroudi WA, Desai MY, Tang WH, Phelan D, Cerqueira MD, Jaber WA. Role of imaging in the diagnosis and management of patients with cardiac amyloidosis: state of the art review and focus on emerging nuclear techniques. J Nucl Cardiol 2014; 21 (2) : 271-83.