TODENTJ-25-03-2019_TODENTJ-11-573 1553507211 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 10 31 2017 11 1 Masoome Eivazi Negar Falahi Nastaran Eivazi Mohammad Ali Eivazi Asad Vaisi Raygani Fatemeh Rezaei Objective: Periodontitis is one of the main diseases in the oral cavity that causes tooth loss. The host immune response and inflammatory factors have important role in periodontal tissue. The current study was done with the objective to determine the effect of scaling and root planning on the salivary concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-alpha (IL-1α). Methods: In this quasi-experimental clinical trial, 29 patients with chronic periodontitis and 29 healthy subjects without periodontitis were studied. Clinical examination findings and salivary TNF-α and IL-1α (using ELISA method) were compared before and after scaling, root planning. Results: Before starting treatment, salivary TNF-α and IL-1α concentrations were higher in healthy control group than in periodontitis group (P< 0.05). Non-surgical treatment increased the concentration of these two biomarkers in the saliva. However, increase in IL-1α concentration was not statistically significant (P= 0.056). There was a negative relationship between TNF-α and IL-1α levels with pocket depth and attachment loss (P< 0.05). Conclusion: Scaling and root planning improved periodontal disease indices and salivary TNF-α and IL-1α levels. 10 31 2017 573 580 TODENTJ-11-573 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2017-05-07 2017-08-24 2017-10-11 2017-10-31 https://creativecommons.org/licenses/by/4.0/legalcode 10.2174/1874210601711010573 1553507211 https://opendentistryjournal.com/VOLUME/11/PAGE/573/ https://opendentistryjournal.com/contents/volumes/V11/TODENTJ-11-573/TODENTJ-11-573.pdf https://opendentistryjournal.com/contents/volumes/V11/TODENTJ-11-573/TODENTJ-11-573.pdf https://opendentistryjournal.com/contents/volumes/V11/TODENTJ-11-573/TODENTJ-11-573.pdf https://opendentistryjournal.com/contents/volumes/V11/TODENTJ-11-573/TODENTJ-11-573.pdf https://opendentistryjournal.com/contents/volumes/V11/TODENTJ-11-573/TODENTJ-11-573.pdf https://opendentistryjournal.com/contents/volumes/V11/TODENTJ-11-573/TODENTJ-11-573.pdf https://opendentistryjournal.com/contents/volumes/V11/TODENTJ-11-573/TODENTJ-11-573.pdf https://opendentistryjournal.com/contents/volumes/V11/TODENTJ-11-573/TODENTJ-11-573.xml 10.1155/2013/127905 Cafiero C, Matarasso M, Marenzi G, Iorio Siciliano V, Bellia L, Sammartino G. 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