TODENTJ-25-03-2019_TODENTJ-11-155
1553506999
Bentham Open
doi@benthamopen.net
Bentham Open
The Open Dentistry Journal
TODENTJ
1874-2106
03
31
2017
11
1
Xerostomia and Salivary Gland Hypofunction in Patients with Oral Lichen Planus Before and After Treatment with Topical Corticosteroids
Hala
Al-Janaby
Haytham
El-Sakka
Manal
Masood
Walimuni
Ashani W. Mendis
Linda
M. Slack-Smith
Richard
Parsons
Agnieszka
M. Frydrych
Background:
Oral lichen planus and mouth dryness are common pathoses, yet not entirely understood. These two conditions may be associated, with a few studies investigating the relationship between mouth dryness and oral lichen planus providing conflicting results. None of the studies have explored the specific impact of disease treatment on mouth dryness.
Objective:
The purpose of this observational before and after comparison study was to examine the effect of treatment of oral lichen planus with topical corticosteroids on mouth dryness.
Methods:
Nineteen subjects with oral lichen planus were evaluated for the severity of xerostomia using a xerostomia inventory and a visual analogue scale. Stimulated and unstimulated whole salivary flow rates, unstimulated salivary pH and buffering capacity were also measured. All subjects were evaluated before and after treatment with topical corticosteroids.
Results:
All subjects reported xerostomia before treatment with topical corticosteroids, with 79% reporting a significant improvement (P = 0.03) after treatment. Topical corticosteroid treatment was not associated with statistically significant differences in stimulated or unstimulated salivary flow rates, unstimulated salivary pH or buffering capacity.
Conclusion:
The results of this study suggest that treatment of oral lichen planus with topical corticosteroids may decrease the severity of dry mouth symptoms.
03
31
2017
155
163
TODENTJ-11-155
1
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Peer Reviewed
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2017-02-16
2017-02-28
2017-03-31
https://creativecommons.org/licenses/by/4.0/legalcode
10.2174/1874210601711010155
1553506999
https://opendentistryjournal.com/VOLUME/11/PAGE/155/
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Otolaryngol. Clin. North Am.
Parashar P.
44
89
2011
10.1016/j.otc.2010.09.004
Parashar P.
Oral lichen planus.
Otolaryngol Clin North Am
2011;
44
(1)
: 89-107, vi.
[Available from: Science Direct].
Dent. Clin. North Am.
Sciubba J.J.
55
89
2011
10.1016/j.cden.2010.08.008
Sciubba JJ.
Autoimmune oral mucosal diseases: clinical, etiologic, diagnostic, and treatment considerations.
Dent Clin North Am
2011;
55
(1)
: 89-103.
[Available from: ClinicalKey].
Ann. N. Y. Acad. Sci.
Jensen J.L.
842
156
1998
10.1111/j.1749-6632.1998.tb09643.x
Jensen JL, Barkvoll P.
Clinical implications of the dry mouth. Oral mucosal diseases.
Ann N Y Acad Sci
1998;
842
: 156-62.
[Available from: Wiley Online Library].
J. Oral Pathol. Med.
Ergun S.
40
286
2011
10.1111/j.1600-0714.2010.00955.x
Ergun S, Troşala SC, Warnakulasuriya S, et al.
Evaluation of oxidative stress and antioxidant profile in patients with oral lichen planus.
J Oral Pathol Med
2011;
40
(4)
: 286-93.
[Available from: Science Direct].
Cochrane Database Syst. Rev.
Thongprasom K.
CD001168
2011
Thongprasom K, Carrozzo M, Furness S, Lodi G.
Interventions for treating oral lichen planus.
Cochrane Database Syst Rev
2011;
(7):
CD001168.
[Available from: Cochrane Database of Systematic Reviews].
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Al-Hashimi I.
103
e1
2007
Al-Hashimi I, Schifter M, Lockhart PB, et al.
Oral lichen planus and oral lichenoid lesions: Diagnostic and therapeutic considerations.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2007;
103
(Suppl: S25)
: e1-e12.
Available from: Science Direct.
Diabetes Res. Clin. Pract.
Seyhan M.
77
198
2007
10.1016/j.diabres.2006.12.016
Seyhan M, Özcan H, Sahin I, Bayram N, Karincaoğlu Y.
High prevalence of glucose metabolism disturbance in patients with lichen planus.
Diabetes Res Clin Pract
2007;
77
(2)
: 198-202.
[Available from: Science Direct].
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Colquhoun A.N.
98
60
2004
10.1016/j.tripleo.2003.11.003
Colquhoun AN, Ferguson MM.
An association between oral lichen planus and a persistently dry mouth.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2004;
98
(1)
: 60-8.
[Available from: Science Direct].
Dermatol. Ther. (Heidelb.)
Schlosser B.J.
23
251
2010
10.1111/j.1529-8019.2010.01322.x
Schlosser BJ.
Lichen planus and lichenoid reactions of the oral mucosa.
Dermatol Ther (Heidelb)
2010;
23
(3)
: 251-67.
[Available from: Wiley Online Library].
Oral Dis.
Artico G.
20
e36
2014
10.1111/odi.12120
Artico G, Freitas RS, Santos Filho AM, Benard G, Romiti R, Migliari DA.
Prevalence of Candida spp., xerostomia, and hyposalivation in oral lichen planusa controlled study.
Oral Dis
2014;
20
(3)
: e36-41.
[Available from: Wiley Online Library].
Oral Oncol.
van der Meij E.H.
43
742
2007
10.1016/j.oraloncology.2006.09.006
van der Meij EH, Mast H, van der Waal I.
The possible premalignant character of oral lichen planus and oral lichenoid lesions: A prospective five-year follow-up study of 192 patients.
Oral Oncol
2007;
43
(8)
: 742-8.
[Available from: Science Direct].
Eur. J. Oral Sci.
Bokor-Bratic M.
121
427
2013
10.1111/eos.12073
Bokor-Bratic M, Cankovic M, Dragnic N.
Unstimulated whole salivary flow rate and anxiolytics intake are independently associated with oral Candida infection in patients with oral lichen planus.
Eur J Oral Sci
2013;
121
(5)
: 427-33.
[Available from: Wiley Online Library].
J. Dent. Res.
Gandara B.K.
64
1149
1985
10.1177/00220345850640091101
Gandara BK, Izutsu KT, Truelove EL, Ensign WY, Sommers EE.
Age-related salivary flow rate changes in controls and patients with oral lichen planus.
J Dent Res
1985;
64
(9)
: 1149-51.
[Available from: EBSCOhost].
J. Dent. Res.
Gandara B.K.
66
1619
1987
10.1177/00220345870660110201
Gandara BK, Izutsu KT, Truelove EL, Mandel ID, Sommers EE, Ensign WY.
Sialochemistry of whole, parotid, and labial minor gland saliva in patients with oral lichen planus.
J Dent Res
1987;
66
(11)
: 1619-22.
[Available from: EBSCOhost].
Scand. J. Dent. Res.
Lundström I.M.
90
443
1982
Lundström IM, Anneroth KG, Bergstedt HF, Bergstedt HF.
Salivary gland function and changes in patients with oral lichen planus.
Scand J Dent Res
1982;
90
(6)
: 443-58.
[Available from: EBSCOhost].
Med. Oral
Ramon C.
5
187
2000
Ramon C, Bagan JV, Milian MA, Jimenez Y, Lloria E.
Quantitative analysis of saliva in patients with oral lichen planus: A study of 100 cases.
Med Oral
2000;
5
(3)
: 187-92.
[Available from: Medline].
Aust. Dent. J.
Thomson W.M.
60
54
2015
10.1111/adj.12284
Thomson WM.
Dry mouth and older people.
Aust Dent J
2015;
60
(Suppl. 1)
: 54-63.
[Available from: Wiley Online Library].
Adv. Dent. Res.
Nederfors T.
14
48
2000
10.1177/08959374000140010701
Nederfors T.
Xerostomia and hyposalivation.
Adv Dent Res
2000;
14
: 48-56.
[Available from: EBSCOhost].
Contemp. Clin. Dent.
Shetty S.R.
3
173
2012
10.4103/0976-237X.96821
Shetty SR, Bhowmick S, Castelino R, Babu S.
Drug induced xerostomia in elderly individuals: An institutional study.
Contemp Clin Dent
2012;
3
(2)
: 173-5.
l [Available from: EBSCOhost].
Oral Dis.
Thelin W.R.
14
683
2008
10.1111/j.1601-0825.2008.01486.x
Thelin WR, Brennan MT, Lockhart PB, et al.
The oral mucosa as a therapeutic target for xerostomia.
Oral Dis
2008;
14
(8)
: 683-9.
[Available from: Wiley Online Library].
10.5005/jp/books/12631
Ghom AG, Ghom SA.
Textbook of Oral Medicine. 3rd ed.
New Delhi: Jaypee Brothers Medical Publishers 2014; pp.
608-9.
Clin. Oral Investig.
van der Putten G-J.
15
185
2011
10.1007/s00784-010-0382-1
van der Putten G-J, Brand HS, Schols JM, de Baat C.
The diagnostic suitability of a xerostomia questionnaire and the association between xerostomia, hyposalivation and medication use in a group of nursing home residents.
Clin Oral Investig
2011;
15
(2)
: 185-92.
[Available from: SpringerLink].
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Pai S.
91
311
2001
10.1067/moe.2001.111551
Pai S, Ghezzi EM, Ship JA.
Development of a visual analogue scale questionnaire for subjective assessment of salivary dysfunction.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2001;
91
(3)
: 311-6.
[Available from: Science Direct].
Int. Dent. J.
Sreebny L.M.
50
140
2000
10.1111/j.1875-595X.2000.tb00554.x
Sreebny LM.
Saliva in health and disease: an appraisal and update.
Int Dent J
2000;
50
(3)
: 140-61.
[Available from: Wiley Online Library].
Ann. N.Y. Acad. Sci.
Navazesh M.
694
72
1993
10.1111/j.1749-6632.1993.tb18343.x
Navazesh M.
Methods for collecting saliva.
Ann NY Acad Sci
1993;
694
(1)
: 72-7.
[Available from: Wiley Online Library].
Acta Odontol. Scand.
Johansson A-K.
70
251
2012
10.3109/00016357.2011.640285
Johansson A-K, Jorkjend L, Marthinussen MC, Johansson A.
A comparison of two clinical methods for measuring saliva in patients with Sjögrens syndrome.
Acta Odontol Scand
2012;
70
(3)
: 251-4.
[Available from: EBSCOhost].
Soc. Sci. Med.
Kandrack M.A.
32
579
1991
10.1016/0277-9536(91)90293-L
Kandrack MA, Grant KR, Segall A.
Gender differences in health related behaviour: Some unanswered questions.
Soc Sci Med
1991;
32
(5)
: 579-90.
[Available from: Science Direct].
Oral Surg. Oral Med. Oral Pathol. Oral Radiol.
Liu B.
114
52
2012
10.1016/j.oooo.2011.11.014
Liu B, Dion MR, Jurasic MM, Gibson G, Jones JA.
Xerostomia and salivary hypofunction in vulnerable elders: prevalence and etiology.
Oral Surg Oral Med Oral Pathol Oral Radiol
2012;
114
(1)
: 52-60.
[Available from: Science Direct].
Gerodontology
Gerdin E.W.
22
219
2005
10.1111/j.1741-2358.2005.00087.x
Gerdin EW, Einarson S, Jonsson M, Aronsson K, Johansson I.
Impact of dry mouth conditions on oral health-related quality of life in older people.
Gerodontology
2005;
22
(4)
: 219-26.
[Available from: Wiley Online Library].
PLoS One
Kersten P.
9
e99485
2014
10.1371/journal.pone.0099485
Kersten P, White PJ, Tennant A.
Is the pain visual analogue scale linear and responsive to change? An exploration using Rasch analysis.
PLoS One
2014;
9
(6)
: e99485.
[Available from: Proquest Public Health].
J. Clin. Nurs.
Crichton N.
10
706
2001
Crichton N.
Visual Analogue Scale (VAS).
J Clin Nurs
2001;
10
(5)
: 706.
[Available from: EBSCOhost].
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Thomson W.M.
112
322
2011
10.1016/j.tripleo.2011.03.024
Thomson WM, van der Putten GJ, de Baat C, et al.
Shortening the xerostomia inventory.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2011;
112
(3)
: 322-7.
[Available from: Science Direct].
Br. Dent. J.
Bots C.P.
217
E3
2014
10.1038/sj.bdj.2014.597
Bots CP, Beest AV, Brand HS.
The assessment of oral dryness by photographic appearance of the tongue.
Br Dent J
2014;
217
(2)
: E3.
[Available from: British Dental Journal].
Chin. J. Dent. Res.
Zhang G.H.
18
135
2015
Zhang GH, Castro R.
Role of oral mucosal fluid and electrolyte absorption and secretion in dry mouth.
Chin J Dent Res
2015;
18
(3)
: 135-54.
[Available from: Medline].
Acta Odontol. Scand.
Jensen K.E.
22
323
1964
10.3109/00016356409028208
Jensen KE, Lund V, Tryde G, Brun GC.
The effect of inflammation on the permeability of human palatal rpithelium to urea.
Acta Odontol Scand
1964;
22
: 323-31.
[Available from: Taylor & Francis].
Scand. J. Dent. Res.
Riber E.
86
386
1978
Riber E, Kaaber S.
Barrier properties of inflamed denture-loaded palatal mucosa to water.
Scand J Dent Res
1978;
86
(5)
: 386-91.
[Available from: EBSCOhost].
Aust. Dent. J.
Sugerman P.B.
47
290
2002
10.1111/j.1834-7819.2002.tb00540.x
Sugerman PB, Savage NW.
Oral lichen planus: causes, diagnosis and management.
Aust Dent J
2002;
47
(4)
: 290-7.
[Available from: Wiley Online Library].
Rev. Esp. Enferm. Dig.
Fenoll-Palomares C.
96
773
2004
10.4321/S1130-01082004001100005
Fenoll-Palomares C, Muñoz Montagud JV, Sanchiz V, et al.
Unstimulated salivary flow rate, pH and buffer capacity of saliva in healthy volunteers.
Rev Esp Enferm Dig
2004;
96
(11)
: 773-83.
[Available from: Medline].
Oral Dis.
Osailan S.
17
109
2011
10.1111/j.1601-0825.2010.01715.x
Osailan S, Pramanik R, Shirodaria S, Challacombe SJ, Proctor GB.
Investigating the relationship between hyposalivation and mucosal wetness.
Oral Dis
2011;
17
(1)
: 109-14.
[Available from: Wiley Online Library].