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        <full_title>The Open Dentistry Journal</full_title>
        <abbrev_title>TODENTJ</abbrev_title>
        <issn media_type="print">1874-2106</issn>
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        <publication_date media_type="print">
          <month>3</month>
          <day>25</day>
          <year>2016</year>
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          <volume>10</volume>
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        <issue>1</issue>
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        <titles>
          <title>Changes in the Oral Moisture and the Amount of Microorganisms in Saliva and Tongue Coating after Oral Ingestion Resumption: A Pilot Study</title>
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        <contributors>
          <person_name contributor_role="author" sequence="first">
            <given_name>Natsuki</given_name>
            <surname>Kishimoto</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Roxana</given_name>
            <surname>Stegaroiu</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Satoko</given_name>
            <surname>Shibata</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Kayoko</given_name>
            <surname>Ito</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Makoto</given_name>
            <surname>Inoue</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Akitsugu</given_name>
            <surname>Ohuchi</surname>
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                    <jats:title>Background and Objective:</jats:title>
                    <jats:p>Tube feeding has been significantly associated with a higher rate of aspiration pneumonia that is mainly related to oral microorganisms and a reduced salivary flow. Thus, the difference in the mode of nutritional intake is expected to affect the oral environment, but this has not yet been fully clarified. The purpose of this study was to investigate, in tube-fed patients, changes in the oral moisture and the counts of microorganisms in saliva and tongue coating, which occur after oral ingestion resumption.</jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Methods:</jats:title>
                    <jats:p>Study participants were 7 tube-fed inpatients of the Niigata University Medical and Dental Hospital (72.7±8.5 years old) who received dysphagia rehabilitation at the Unit of Dysphagia Rehabilitation until oral ingestion resumption. Their oral health, swallowing, and nutrition status, oral mucosal moisture, amount of unstimulated saliva and the counts of microorganisms (total microorganisms, streptococci, <jats:italic>Candida</jats:italic>) in saliva and tongue coating were investigated and compared before and after the recommencement of oral intake.</jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Results:</jats:title>
                    <jats:p>Tongue coating, choking, oral mucosal moisture and amount of unstimulated saliva were improved significantly after resumption of oral ingestion. The other investigated parameters did not significantly change, except for the streptococci in tongue coating, which significantly increased 1 week after oral ingestion recommencement, but decreased thereafter.</jats:p>
                </jats:sec>
                <jats:sec>
                    <jats:title>Conclusion:</jats:title>
                    <jats:p>After oral intake resumption, oral mucosal moisture and amount of unstimulated saliva were improved. However, because of a transitory increase in the counts of streptococci with oral ingestion recommencement, it is important to appropriately manage oral hygiene in these patients, according to the changes in their intraoral microbiota.</jats:p>
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            </jats:abstract>
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          <year>2016</year>
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          <first_page>79</first_page>
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        <citation_list>
          <citation key="refR1">
            <journal_title>Dysphagia</journal_title>
            <author>Langmore S.E.</author>
            <volume>13</volume>
            <first_page>69</first_page>
            <cYear>1998</cYear>
            <doi>10.1007/PL00009559</doi>
            <unstructured_citation>
                    Langmore SE, Terpenning MS, Schork A, et al. 
                    Predictors of aspiration pneumonia: how important is dysphagia? 
                    Dysphagia  
                    1998; 
                    13
                    (2)
                    : 69-81.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR2">
            <unstructured_citation>
                    Ministry of Health. 
                    Labour and Welfare Japan. Available from: http://www.mhlw.go.jp/english/database/db-hh/1-2.html 
                    2011.
                    
                 [Accessed on: 18 March 2013].</unstructured_citation>
          </citation>
          <citation key="refR3">
            <journal_title>Dysphagia</journal_title>
            <author>Langmore S.E.</author>
            <volume>17</volume>
            <first_page>298</first_page>
            <cYear>2002</cYear>
            <doi>10.1007/s00455-002-0072-5</doi>
            <unstructured_citation>
                    Langmore SE, Skarupski KA, Park PS, Fries BE. 
                    Predictors of aspiration pneumonia in nursing home residents. 
                    Dysphagia  
                    2002; 
                    17
                    (4)
                    : 298-307.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR4">
            <journal_title>Dysphagia</journal_title>
            <author>Pace C.C.</author>
            <volume>25</volume>
            <first_page>307</first_page>
            <cYear>2010</cYear>
            <doi>10.1007/s00455-010-9298-9</doi>
            <unstructured_citation>
                    Pace CC, McCullough GH. 
                    The association between oral microorgansims and aspiration pneumonia in the institutionalized elderly: review and recommendations. 
                    Dysphagia  
                    2010; 
                    25
                    (4)
                    : 307-22.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR5">
            <journal_title>J. Am. Geriatr. Soc.</journal_title>
            <author>Teramoto S.</author>
            <volume>56</volume>
            <first_page>577</first_page>
            <cYear>2008</cYear>
            <doi>10.1111/j.1532-5415.2008.01597.x</doi>
            <unstructured_citation>
                    Teramoto S, Fukuchi Y, Sasaki H, Sato K, Sekizawa K, Matsuse T. 
                    Japanese Study Group on Aspiration Pulmonary Disease. 
                    High incidence of aspiration pneumonia in community- and hospital-acquired pneumonia in hospitalized patients: a multicenter, prospective study in Japan. 
                    J Am Geriatr Soc  
                    2008; 
                    56
                    (3)
                    : 577-9.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR6">
            <journal_title>J. Periodontol.</journal_title>
            <author>Scannapieco F.A.</author>
            <volume>67</volume>
            <first_page>1114</first_page>
            <cYear>1996</cYear>
            <doi>10.1902/jop.1996.67.10s.1114</doi>
            <unstructured_citation>
                    Scannapieco FA, Mylotte JM. 
                    Relationships between periodontal disease and bacterial pneumonia. 
                    J Periodontol  
                    1996; 
                    67
                    (Suppl. 10)
                    : 1114-22.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR7">
            <journal_title>J. Periodontol.</journal_title>
            <author>Okuda K.</author>
            <volume>76</volume>
            <first_page>2154</first_page>
            <cYear>2005</cYear>
            <doi>10.1902/jop.2005.76.11-S.2154</doi>
            <unstructured_citation>
                    Okuda K, Kimizuka R, Abe S, et al. 
                    Involvement of periodontopathic biofilm in respiratory infections. 
                    J Periodontol  
                    2005; 
                    76
                    (Suppl. 11)
                    : 2154-60.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR8">
            <journal_title>Drugs Aging</journal_title>
            <author>Kikawada M.</author>
            <volume>22</volume>
            <first_page>115</first_page>
            <cYear>2005</cYear>
            <doi>10.2165/00002512-200522020-00003</doi>
            <unstructured_citation>
                    Kikawada M, Iwamoto T, Takasaki M. 
                    Aspiration and infection in the elderly : epidemiology, diagnosis and management. 
                    Drugs Aging  
                    2005; 
                    22
                    (2)
                    : 115-30.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR9">
            <journal_title>J. Am. Geriatr. Soc.</journal_title>
            <author>Yoneyama T.</author>
            <volume>50</volume>
            <first_page>430</first_page>
            <cYear>2002</cYear>
            <doi>10.1046/j.1532-5415.2002.50106.x</doi>
            <unstructured_citation>
                    Yoneyama T, Yoshida M, Ohrui T, et al. 
                    Oral care reduces pneumonia in older patients in nursing homes. 
                    J Am Geriatr Soc  
                    2002; 
                    50
                    (3)
                    : 430-3.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR10">
            <journal_title>Gerodontology</journal_title>
            <author>van der Maarel-Wierink C.D.</author>
            <volume>30</volume>
            <first_page>3</first_page>
            <cYear>2013</cYear>
            <doi>10.1111/j.1741-2358.2012.00637.x</doi>
            <unstructured_citation>
                    van der Maarel-Wierink CD, Vanobbergen JN, Bronkhorst EM, Schols JM, de Baat C. 
                    Oral health care and aspiration pneumonia in frail older people: a systematic literature review. 
                    Gerodontology  
                    2013; 
                    30
                    (1)
                    : 3-9.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR11">
            <journal_title>Int. J. Dent. Hyg.</journal_title>
            <author>Adachi M.</author>
            <volume>5</volume>
            <first_page>69</first_page>
            <cYear>2007</cYear>
            <doi>10.1111/j.1601-5037.2007.00233.x</doi>
            <unstructured_citation>
                    Adachi M, Ishihara K, Abe S, Okuda K. 
                    Professional oral health care by dental hygienists reduced respiratory infections in elderly persons requiring nursing care. 
                    Int J Dent Hyg  
                    2007; 
                    5
                    (2)
                    : 69-74.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR12">
            <journal_title>J. Am. Acad. Nurse Pract.</journal_title>
            <author>Sue Eisenstadt E.</author>
            <volume>22</volume>
            <first_page>17</first_page>
            <cYear>2010</cYear>
            <doi>10.1111/j.1745-7599.2009.00470.x</doi>
            <unstructured_citation>
                    Sue Eisenstadt E. 
                    Dysphagia and aspiration pneumonia in older adults. 
                    J Am Acad Nurse Pract  
                    2010; 
                    22
                    (1)
                    : 17-22.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR13">
            <journal_title>Gerodontology</journal_title>
            <author>Ueda K.</author>
            <volume>21</volume>
            <first_page>108</first_page>
            <cYear>2004</cYear>
            <doi>10.1111/j.1741-2358.2004.00016.x</doi>
            <unstructured_citation>
                    Ueda K, Yamada Y, Toyosato A, Nomura S, Saitho E. 
                    Effects of functional training of dysphagia to prevent pneumonia for patients on tube feeding. 
                    Gerodontology  
                    2004; 
                    21
                    (2)
                    : 108-11.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR14">
            <unstructured_citation>
                    Edgar WM, Dawes C, O’Mullane DM, Eds. 
                    Saliva and oral health.  3rd ed. 
                    London: British Dental Association 2004.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR15">
            <journal_title>J Jpn Soc Dent Hyg</journal_title>
            <author>Tsukada S.</author>
            <volume>7</volume>
            <first_page>43</first_page>
            <cYear>2012</cYear>
            <unstructured_citation>
                    Tsukada S, Shibata S, Kajii Y, et al. 
                    Investigation of screening sheet for multiple-professional use to judge necessity for dental intervention in inpatients: Considerations based on comparison of screening results by dentist and dental hygienist. 
                    J Jpn Soc Dent Hyg  
                    2012; 
                    7
                    : 43-54.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR16">
            <journal_title>Aust. Dent. J.</journal_title>
            <author>Chalmers J.M.</author>
            <volume>50</volume>
            <first_page>191</first_page>
            <cYear>2005</cYear>
            <doi>10.1111/j.1834-7819.2005.tb00360.x</doi>
            <unstructured_citation>
                    Chalmers JM, King PL, Spencer AJ, Wright FA, Carter KD. 
                    The oral health assessment tool--validity and reliability. 
                    Aust Dent J  
                    2005; 
                    50
                    (3)
                    : 191-9.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR17">
            <journal_title>Gerodontology</journal_title>
            <author>Ichikawa K.</author>
            <volume>28</volume>
            <first_page>116</first_page>
            <cYear>2011</cYear>
            <doi>10.1111/j.1741-2358.2009.00358.x</doi>
            <unstructured_citation>
                    Ichikawa K, Sakuma S, Yoshihara A, et al. 
                    Relationships between the amount of saliva and medications in elderly individuals. 
                    Gerodontology  
                    2011; 
                    28
                    (2)
                    : 116-20.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR18">
            <journal_title>Niigata Dent J</journal_title>
            <author>Funayama S.</author>
            <volume>38</volume>
            <first_page>37</first_page>
            <cYear>2008</cYear>
            <unstructured_citation>
                    Funayama S, Ito K, Nohno K, et al. 
                    Comparative study of salivary secretion in cotton roll method and spitting method. 
                    Niigata Dent J  
                    2008; 
                    38
                    : 37-43.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR19">
            <journal_title>Oral Dis.</journal_title>
            <author>Yamada H.</author>
            <volume>11</volume>
            <first_page>405</first_page>
            <cYear>2005</cYear>
            <doi>10.1111/j.1601-0825.2005.01136.x</doi>
            <unstructured_citation>
                    Yamada H, Nakagawa Y, Nomura Y, et al. 
                    Preliminary results of moisture checker for mucus in diagnosing dry mouth. 
                    Oral Dis  
                    2005; 
                    11
                    (6)
                    : 405-7.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR20">
            <journal_title>Auris Nasus Larynx</journal_title>
            <author>Ishimoto S.</author>
            <volume>35</volume>
            <first_page>89</first_page>
            <cYear>2008</cYear>
            <doi>10.1016/j.anl.2007.05.002</doi>
            <unstructured_citation>
                    Ishimoto S, Tsunoda K, Fujimaki Y, et al. 
                    Objective and non-invasive evaluation of dry mouth. 
                    Auris Nasus Larynx  
                    2008; 
                    35
                    (1)
                    : 89-93.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR21">
            <journal_title>J. Stomatology</journal_title>
            <author>Fukushima Y.</author>
            <volume>3</volume>
            <first_page>440</first_page>
            <cYear>2013</cYear>
            <doi>10.4236/ojst.2013.38073</doi>
            <unstructured_citation>
                    Fukushima Y, Yoda T, Kokabu S, et al. 
                    Evaluation of an oral moisture-checking device for screening dry mouth. 
                    J Stomatology  
                    2013; 
                    3
                    : 440-6.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR22">
            <journal_title>Arch. Gerontol. Geriatr.</journal_title>
            <author>Nishiyama Y.</author>
            <volume>51</volume>
            <first_page>e139</first_page>
            <cYear>2010</cYear>
            <doi>10.1016/j.archger.2010.04.009</doi>
            <unstructured_citation>
                    Nishiyama Y, Inaba E, Uematsu H, Senpuku H. 
                    Effects of mucosal care on oral pathogens in professional oral hygiene to the elderly. 
                    Arch Gerontol Geriatr  
                    2010; 
                    51
                    (3)
                    : e139-43.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR23">
            <journal_title>Ronen Shika Igaku</journal_title>
            <author>Hisano A.</author>
            <volume>24</volume>
            <first_page>354</first_page>
            <cYear>2009</cYear>
            <unstructured_citation>
                    Hisano A, Kikutani T, Tashiro H, et al. 
                    The effect of sampling pressure applied to the tongue on bacterial counts. 
                    Ronen Shika Igaku  
                    2009; 
                    24
                    : 354-9.
                    
                </unstructured_citation>
          </citation>
          <citation key="refR24">
            <journal_title>Microb. Ecol. Health Dis.</journal_title>
            <author>Hori R.</author>
            <volume>11</volume>
            <first_page>89</first_page>
            <cYear>1999</cYear>
            <doi>10.1080/089106099435826</doi>
            <unstructured_citation>
                    Hori R, Sato M, Kohno S, et al. 
                    Tongue microflora in edentulous geriatric denture- wearers. 
                    Microb Ecol Health Dis  
                    1999; 
                    11
                    : 89-95.
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR25">
            <journal_title>Gerodontology</journal_title>
            <author>Ogasawara T.</author>
            <volume>25</volume>
            <first_page>217</first_page>
            <cYear>2008</cYear>
            <doi>10.1111/j.1741-2358.2007.00213.x</doi>
            <unstructured_citation>
                    Ogasawara T, Andou N, Kawase S, et al. 
                    Potential factors responsible for dryness of the dorsum of the tongue in elderly requiring care. 
                    Gerodontology  
                    2008; 
                    25
                    (4)
                    : 217-21.
                    
                    
                    
                </unstructured_citation>
          </citation>
          <citation key="refR26">
            <journal_title>J Oral Microbiol</journal_title>
            <author>Moye ZD</author>
            <volume>6.</volume>
            <cYear>2014</cYear>
            <doi>10.3402/jom.v6.24878</doi>
            <unstructured_citation>
                    Moye ZD, Zeng L, Burne RA. 
                    Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans. 
                    J Oral Microbiol  
                    2014; 
                    6.
                    
                    
                    
                 Available from: http://www.journaloforalmicrobiology.net/index.php/jom/article/view/24878</unstructured_citation>
          </citation>
        </citation_list>
      </journal_article>
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