Are Pediatric Antibiotic Formulations Potentials Risk Factors for Dental Caries and Dental Erosion?

TODENTJ-25-03-2019_TODENTJ-10-420 1553506550 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 08 22 2016 10 1 Are Pediatric Antibiotic Formulations Potentials Risk Factors for Dental Caries and Dental Erosion? Ana Carolina Valinoti Luiz Carlos da Costa Jr. Adriana Farah Valéria Pereira de Sousa Andréa Fonseca-Gonçalves Lucianne Cople Maia Introduction: One of the most frequent parents’ concerns is that oral antibiotic formulations induce dental damage in their children’s. This study aimed to assess the cariogenic and erosive potentials of 29 pediatric antibiotics. Materials and Methods: Replicates of each antibiotic were analyzed for the concentration of sugars (sucrose, glucose and fructose) and sorbitol by high performance liquid chromatography (HPLC). The pH was determined by digital pHmeter. Titratable acidity was determined in triplicate using the same pHmeter by gradual addition of 0.1N sodium hydroxide (NaOH) until pH 7.0. Viscosity measurements were carried out using a viscosimeter. In order to rank the relative performance of each medicine, the DEA (Data Envelopment Analysis) methodology was used. Results: Sucrose was present in most samples (n=24) with concentrations ranging from 26 to ≈ 100g% (w/w). Only one antibiotic contained sorbitol (66.9g%). Twenty seven antibiotics presented pH values ranging from 4.1 to 6.9 and most of them (n=15) showed the pH below the critical value for dissolution of hydroxyapatite. The values of titratable acidity and viscosity ranged from 0.26 to 40.48 ml and from 20 to 1780cP, respectively. DEA methodology showed that two medicines were distant from the performance frontier (Klaricid® 50mg and Zinnat® 250mg), which means that these medicines showed the worst performance and, therefore, greater potential for dissolution of dental enamel. Conclusion: Many antibiotics presented high concentration of sugars, high titratable acidity, pH below the critical value and high viscosity which can be considered risk factors for dental caries and erosion, when consumed frequently. 08 22 2016 420 430 TODENTJ-10-420 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2015-2-16 2016-6-20 2016-7-15 2016-08-22 https://creativecommons.org/licenses/by-nc/4.0/legalcode 10.2174/1874210601610010420 1553506550 https://opendentistryjournal.com/VOLUME/10/PAGE/420/ https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-420/TODENTJ-10-420.pdf https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-420/TODENTJ-10-420.pdf https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-420/TODENTJ-10-420.pdf https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-420/TODENTJ-10-420.pdf https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-420/TODENTJ-10-420.pdf https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-420/TODENTJ-10-420.pdf https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-420/TODENTJ-10-420.pdf https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-420/TODENTJ-10-420.xml Pediatrics 99 268 1997 10.1542/peds.99.2.268 “Inactive” ingredients in pharmaceutical products: update (subject review). 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