TODENTJ-25-03-2019_TODENTJ-10-174
1553506453
Bentham Open
doi@benthamopen.net
Bentham Open
The Open Dentistry Journal
TODENTJ
1874-2106
05
11
2016
10
1
Platelet Rich Fibrin in Periodontal Regeneration
Muthukumaraswamy
Arunachalam
Shaju J.
Pulikkotil
Nath
Sonia
Periodontitis is a chronic bacterial infection resulting in destruction of the supporting structures of the teeth. Regeneration of the lost tissues has faced difficulties primarily due to the lack of support during the intricate healing processes. A surgical additive which can ‘jump start’ the healing process to a more predictable regenerative process is always on the wish list of any periodontist. Platelet-rich fibrin (PRF) is a second generation platelet concentrate that has been considered to be an important, easy to obtain, predictable surgical additive for periodontal
regeneration. This autologous scaffold provides the much needed bio-chemical mediators which has the potential for enhancing reconstruction of the periodontium. This review article tries to understand as to why PRF would be an important link to reach predictable periodontal regeneration.
05
11
2016
174
181
TODENTJ-10-174
1
10.2174/crossmark_policy
opendentistryjournal.com
benthamopen.com
true
Peer Reviewed
Single blind
Checked with iThenticate
2015-12-30
2016-1-10
2016-01-28
2016-05-11
https://creativecommons.org/licenses/by/4.0/legalcode
10.2174/1874210601610010174
1553506453
https://opendentistryjournal.com/VOLUME/10/PAGE/174/
-
https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-174/TODENTJ-10-174.pdf
-
https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-174/TODENTJ-10-174.pdf
-
https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-174/TODENTJ-10-174.pdf
-
https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-174/TODENTJ-10-174.pdf
-
https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-174/TODENTJ-10-174.pdf
-
https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-174/TODENTJ-10-174.pdf
-
https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-174/TODENTJ-10-174.pdf
-
https://opendentistryjournal.com/contents/volumes/V10/TODENTJ-10-174/TODENTJ-10-174.xml
J. Clin. Periodontol.
Gotlow J.
11
494
1984
10.1111/j.1600-051X.1984.tb00901.x
Gotlow J, Nyman S, Karring T.
New attachment formation in human periodontium by guided tissue regeneration.
J Clin Periodontol
1984;
11
: 494-503.
Ann. Periodontol.
Reynolds M.A.
8
227
2003
10.1902/annals.2003.8.1.227
Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL, Gunsolley JC.
The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review.
Ann Periodontol
2003;
8
(1)
: 227-65.
Med. Res. Rev.
Chen F.M.
29
472
2009
10.1002/med.20144
Chen FM, Shelton RM, Jin Y, Chapple IL.
Localized delivery of growth factors for periodontal tissue regeneration: role, strategies, and perspectives.
Med Res Rev
2009;
29
(3)
: 472-513.
Thromb. Haemost.
Anitua E.
91
4
2004
Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT.
Autologous platelets as a source of proteins for healing and tissue regeneration.
Thromb Haemost
2004;
91
(1)
: 4-15.
J. Extra Corpor. Technol.
Everts P.A.
38
174
2006
Everts PA, Knape JT, Weibrich G, et al.
Platelet-rich plasma and platelet gel: a review.
J Extra Corpor Technol
2006;
38
(2)
: 174-87.
J. Indian Soc. Periodontol.
Shaju J.P.
15
29
2011
10.4103/0972-124X.82261
Shaju JP, Zade RM, Das M.
Prevalence of periodontitis in the Indian population: A literature review.
J Indian Soc Periodontol
2011;
15
(1)
: 29-34.
Glossary of periodontal terms. 3rd ed.
Chicago: Am Acad Periodontol 1992.
J. Periodontol.
Melcher A.H.
47
256
1976
10.1902/jop.1976.47.5.256
Melcher AH.
On the repair potential of periodontal tissues.
J Periodontol
1976;
47
(5)
: 256-60.
J. Clin. Periodontol.
Gotlow J.
11
494
1984
10.1111/j.1600-051X.1984.tb00901.x
Gotlow J, Nyman S, Karring T.
New attachment formation in human periodontium by guided tissue regeneration.
J Clin Periodontol
1984;
11
: 494-503.
J. Clin. Periodontol.
Trombelli L.
29
117
2002
10.1034/j.1600-051X.29.s3.7.x
Trombelli L, Heitz-Mayfield LJ, Needleman I, Moles D, Scabbia A.
A systematic review of graft materials and biological agents for periodontal intraosseous defects.
J Clin Periodontol
2002;
29
(3)
(Suppl. 3)
: 117-35.
J. Periodontal Res.
Needleman I.
37
380
2002
10.1034/j.1600-0765.2002.01369.x
Needleman I, Tucker R, Giedrys-Leeper E, Worthington H.
A systematic review of guided tissue regeneration for periodontal infrabony defects.
J Periodontal Res
2002;
37
(5)
: 380-8.
Ann. Periodontol.
Giannobile W.V.
8
193
2003
10.1902/annals.2003.8.1.193
Giannobile WV, Somerman MJ.
Growth and amelogenin-like factors in periodontal wound healing. A systematic review.
Ann Periodontol
2003;
8
(1)
: 193-204.
Implant Dent.
Wang H.L.
15
8
2006
10.1097/01.id.0000204762.39826.0f
Wang HL, Boyapati L.
“PASS” principles for predictable bone regeneration.
Implant Dent
2006;
15
(1)
: 8-17.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Dohan D.M.
101
e45
2006 b
10.1016/j.tripleo.2005.07.009
Dohan DM, Choukroun J, Diss A, et al.
Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2006 b;
101
(3)
: e45-50.
Proc. Natl. Acad. Sci. USA
Ross R.
71
1207
1974
10.1073/pnas.71.4.1207
Ross R, Glomset J, Kariya B, Harker L.
A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro.
Proc Natl Acad Sci USA
1974;
71
(4)
: 1207-10.
J. Oral Maxillofac. Surg.
Marx R.E.
62
489
2004
10.1016/j.joms.2003.12.003
Marx RE.
Platelet-rich plasma: evidence to support its use.
J Oral Maxillofac Surg
2004;
62
(4)
: 489-96.
J. Periodontol.
Del Fabbro M.
82
1100
2011
10.1902/jop.2010.100605
Del Fabbro M, Bortolin M, Taschieri S, Weinstein R.
Is platelet concentrate advantageous for the surgical treatment of periodontal diseases? A systematic review and meta-analysis.
J Periodontol
2011;
82
(8)
: 1100-11.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Marx R.E.
85
638
1998
10.1016/S1079-2104(98)90029-4
Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR.
Platelet-rich plasma: Growth factor enhancement for bone grafts.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
1998;
85
(6)
: 638-46.
Infect. Immun.
Tang Y.Q.
70
6524
2002
10.1128/IAI.70.12.6524-6533.2002
Tang YQ, Yeaman MR, Selsted ME.
Antimicrobial peptides from human platelets.
Infect Immun
2002;
70
(12)
: 6524-33.
Clin. Oral Implants Res.
Lindeboom J.A.
18
133
2007
10.1111/j.1600-0501.2006.01288.x
Lindeboom JA, Mathura KR, Aartman IH, Kroon FH, Milstein DM, Ince C.
Influence of the application of platelet-enriched plasma in oral mucosal wound healing.
Clin Oral Implants Res
2007;
18
(1)
: 133-9.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Choukroun J.
101
e56
2006
10.1016/j.tripleo.2005.07.011
Choukroun J, Diss A, Simonpieri A, et al.
Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2006;
101
(3)
: e56-60.
Indian J. Dent. Res.
Sunitha Raja V.
19
42
2008
10.4103/0970-9290.38931
Sunitha Raja V, Munirathnam Naidu E.
Platelet-rich fibrin: evolution of a second-generation platelet concentrate.
Indian J Dent Res
2008;
19
(1)
: 42-6.
J. Periodontal Res.
Creeper F.
44
258
2009
10.1111/j.1600-0765.2008.01125.x
Creeper F, Lichanska AM, Marshall RI, Seymour GJ, Ivanovski S.
The effect of platelet-rich plasma on osteoblast and periodontal ligament cell migration, proliferation and differentiation.
J Periodontal Res
2009;
44
(2)
: 258-65.
Int. J. Oral Maxillofac. Implants
Sánchez A.R.
18
93
2003
Sánchez AR, Sheridan PJ, Kupp LI.
Is platelet-rich plasma the perfect enhancement factor? A current review.
Int J Oral Maxillofac Implants
2003;
18
(1)
: 93-103.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Marx R.E.
85
638
1998
10.1016/S1079-2104(98)90029-4
Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR.
Platelet-rich plasma: Growth factor enhancement for bone grafts.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
1998;
85
(6)
: 638-46.
Int. J. Oral Maxillofac. Implants
Anitua E.
14
529
1999
Anitua E.
Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants.
Int J Oral Maxillofac Implants
1999;
14
(4)
: 529-35.
Proc. Natl. Acad. Sci. USA
Ross R.
71
1207
1974
10.1073/pnas.71.4.1207
Ross R, Glomset J, Kariya B, Harker L.
A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro.
Proc Natl Acad Sci USA
1974;
71
(4)
: 1207-10.
Clin. Oral Implants Res.
Raghoebar G.M.
16
349
2005
10.1111/j.1600-0501.2005.01115.x
Raghoebar GM, Schortinghuis J, Liem RS, Ruben JL, van der Wal JE, Vissink A.
Does platelet-rich plasma promote remodeling of autologous bone grafts used for augmentation of the maxillary sinus floor?
Clin Oral Implants Res
2005;
16
(3)
: 349-56.
Clin. Oral Implants Res.
Hamdan A.A.
20
616
2009
Hamdan AA, Loty S, Isaac J, Bouchard P, Berdal A, Sautier J-M.
Platelet-poor plasma stimulates the proliferation but inhibits the differentiation of rat osteoblastic cells in vitro.
Clin Oral Implants Res
2009;
20
(6)
: 616-23.
Implantodont
Choukroun J.
42
55
2001
Choukroun J, Adda F, Schoeffler C, Vervelle A.
A opportunite’ in paroimplantology: the PRF.
Implantodont
2001;
42
: 55-62.
J. Periodontol.
Dohan Ehrenfest D.M.
81
546
2010
10.1902/jop.2009.090531
Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB.
Three-dimensional architecture and cell composition of a Choukroun’s platelet-rich fibrin clot and membrane.
J Periodontol
2010;
81
(4)
: 546-55.
J. Periodontol.
Giannobile W.V.
67
545
1996
Giannobile WV.
The potential role of growth and differentiation factors in periodontal regeneration.
J Periodontol
1996;
67
(5)
: 545-53.
Curr. Opin. Hematol.
Borzini P.
12
473
2005
10.1097/01.moh.0000177831.70657.e8
Borzini P, Mazzucco L.
Platelet gels and releasates.
Curr Opin Hematol
2005;
12
(6)
: 473-9.
Thromb. Haemost.
Anitua E.
91
4
2004
Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT.
Autologous platelets as a source of proteins for healing and tissue regeneration.
Thromb Haemost
2004;
91
(1)
: 4-15.
Biomaterials
Anitua E.
28
4551
2007
10.1016/j.biomaterials.2007.06.037
Anitua E, Sánchez M, Orive G, Andía I.
The potential impact of the preparation rich in growth factors (PRGF) in different medical fields.
Biomaterials
2007;
28
(31)
: 4551-60.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Dohan D.M.
101
e45
2006 b
10.1016/j.tripleo.2005.07.009
Dohan DM, Choukroun J, Diss A, et al.
Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2006 b;
101
(3)
: e45-50.
N. Engl. J. Med.
Border W.A.
331
1286
1994
10.1056/NEJM199411103311907
Border WA, Noble NA.
Transforming growth factor beta in tissue fibrosis.
N Engl J Med
1994;
331
(19)
: 1286-92.
J. Clin. Invest.
Lynch S.E.
84
640
1989
10.1172/JCI114210
Lynch SE, Colvin RB, Antoniades HN.
Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds.
J Clin Invest
1989;
84
(2)
: 640-6.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Dohan D.M.
101
e51
2006 c
10.1016/j.tripleo.2005.07.010
Dohan DM, Choukroun J, Diss A, et al.
Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates?
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2006 c;
101
(3)
: e51-5.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Su C.Y.
108
56
2009
10.1016/j.tripleo.2009.02.004
Su CY, Kuo YP, Tseng YH, Su CH, Burnouf T.
In vitro release of growth factors from platelet-rich fibrin (PRF): a proposal to optimize the clinical applications of PRF.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2009;
108
(1)
: 56-61.
Implant Dent.
Simonpieri A.
18
102
2009
10.1097/ID.0b013e318198cf00
Simonpieri A, Del Corso M, Sammartino G, Dohan Ehrenfest DM.
The relevance of Choukroun’s platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part I: a new grafting protocol.
Implant Dent
2009;
18
(2)
: 102-11.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Dohan D.M.
101
e37
2006 a
10.1016/j.tripleo.2005.07.008
Dohan DM, Choukroun J, Diss A, et al.
Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2006 a;
101
(3)
: e37-44.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
O’Connell S.M.
103
587
2007
10.1016/j.tripleo.2007.03.017
O’Connell SM.
Safety issues associated with platelet-rich fibrin method.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2007;
103
(5)
: 587.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
Dohan D.M.
103
587
2007
10.1016/j.tripleo.2007.03.016
Dohan DM, Del Corso M, Charrier JB.
Cytotoxicity analyses of Choukroun’s PRF (Platelet Rich Fibrin) on a wide range of human cells: the answer to a commercial controversy.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2007;
103
: 587-93.
Ann. N. Y. Acad. Sci.
Mosesson M.W.
936
11
2001
10.1111/j.1749-6632.2001.tb03491.x
Mosesson MW, Siebenlist KR, Meh DA.
The structure and biological features of fibrinogen and fibrin.
Ann N Y Acad Sci
2001;
936
: 11-30.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
He L.
108
707
2009
10.1016/j.tripleo.2009.06.044
He L, Lin Y, Hu X, Zhang Y, Wu H.
A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
2009;
108
(5)
: 707-13.
J Periodontal
Pradeep A.R.
2012
Pradeep AR, Bajaj P, Rao NS, Aggarwal E.
Platelet rich fibrin combined with a porous hydroxy apatite graft for the treatment of 3-walled intrabony defects in chronic periodontitis: A Randomized controlled clinical trial.
J Periodontal
2012.
Facial Plast. Surg.
Sclafani A.P.
25
270
2009
10.1055/s-0029-1242033
Sclafani AP.
Applications of platelet-rich fibrin matrix in facial plastic surgery.
Facial Plast Surg
2009;
25
(4)
: 270-6.
J. Periodontol.
Mazor Z.
80
2056
2009
10.1902/jop.2009.090252
Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD, Dohan EDM.
Sinus floor augmentation with simultaneous implant placement using Choukroun’s platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months.
J Periodontol
2009;
80
(12)
: 2056-64.